The effects of edaravone, a free‐radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

Bayrak, Bertan Boran; Yılmaz, Sabire; Cakmak, Neziha Hacihasanoglu; Yanardağ, Refiye

doi:10.1002/jbt.22847

Cited by 12 publications

(8 citation statements)

References 89 publications

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“…It was shown that TOS levels remarkably increased whereas TAS levels notably decreased in children with seizures taking sixty days on VPA monotherapy [29]. Present findings are line with our recent article [30]. In the present study, administration of edaravone to VPA given rats resulted in decreased ROS, TOS, and OSI levels and increased TAS levels.…”

Section: Discussionsupporting

confidence: 92%

Protective effect of edaravone on rat testis after valproic acid treatment

CELIK¹,

Bayrak²,

Cakmak³

et al. 2022

jrp

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Valproic acid (n-dipropyl-acetic acid, VPA) is a medication used as anticonvulsant in the treatment of bipolar disorder, and for migraine prophylaxis. Long-term use of VPA is known to trigger reproductive impairment, which is mediated by elevation of testicular oxidative stress. Edaravone is used in the treatment of cerebrovascular diseases. It can diffuse into many disease-affected organs, thus shows protective effects in numerous tissues including the heart, lung, and testis. The main goal of the present study was to determine the possible protective role of edaravone against VPA-induced oxidative testicular injury. Male Sprague Dawley rats were assigned into four groups. Control rats; rats given only edaravone (30 mg/kg/day); rats given only VPA (500 mg/kg/day); rats given VPA+edaravone for seven days. Edaravone and VPA were applied intraperitoneally. After eight days, testicular tissues were taken from rats. There was a statistically significant increase in the levels of reduced glutathione, lipid peroxidation, reactive oxygen species, total oxidant status, oxidative stress index, and DNA contents as well as catalase, superoxide dismutase, glutathione-related enzymes, gamma-glutamyl transferase, acid and alkaline phosphatases, lactate dehydrogenase, myeloperoxidase and sorbitol dehydrogenase activities in VPA group. More so, advanced oxidized protein products, protein carbonyl, and nitric oxide levels were also significantly increased in VPA group. Activities of glucose-6phosphate dehydrogenase and sodium/potassium ATPase and total antioxidant status levels remarkably decreased in VPA given group. Treatment with edaravone to VPA group significantly reverted these alterations. These findings demonstrate that administration of edaravone has a beneficial effect against testicular injury in VPA-induced oxidative stress.

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Section: Discussionsupporting

confidence: 92%

Protective effect of edaravone on rat testis after valproic acid treatment

CELIK¹,

Bayrak²,

Cakmak³

et al. 2022

jrp

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“…In addition, ALA has been described as being involved in the most important energy production pathway, the Krebs cycle, where ALA plays a vital role as a coenzyme assisting in the transfer of acyl groups (15). Its protective effects on different systems of VPA and α-cypermethrin have been reported by many researchers, respectively (7,16,17).…”

Section: Introductionmentioning

confidence: 92%

“…Despite its protective and preventive effects, VPA has been declared to have many serious side effects and this drug has taken the lead in the formation and construction of free radical species which damage many tissues and organs like heart, lung, liver, brain, testis, etc. (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Alpha Lipoic Acid on Lens Injury in Rats Administered With Valproic Acid

Öztaylan¹,

Türkyılmaz²,

Yanardağ³

2022

jmed

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Objective: Valproic acid (2-propyl valeric acid; VPA) is an effective short-chained fatty acid which is used for the treatment of migraine and schizophrenia. Though it provides effective treatment, its side effects are associated with free radicals and in this way it affects many organs and tissues. Alpha lipoic acid (ALA) is known to be a powerful antioxidant. Material and Methods: The aim of this current study was to investigate the protection of ALA on VPA induced lens injury. Female rats were split into four groups as follows: 1 st group, control animals (corn oil per day for 15 days); 2 nd group, ALA administered group (50 mg per kg each day for 15 days); 3 rd group, VPA administered group (500 mg per kg each day for 15 days) and 4 th group, VPA and ALA administered group to which the same dose was given at the same time each day. On the 16 th day, lens tissues were taken.Results: Lens glutathione levels and glutathione-S-transferase activities were decreased while lipid peroxidation and protein carbonyl levels, superoxide dismutase, glutathione peroxidase and reductase, aldose reductase and sorbitol dehydrogenase activities were elevated after VPA administration. ALA reversed these levels and activities in the VPA group. Conclusion:We can conclude that ALA used its antioxidant property and ameliorated VPA induced lens injury.

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“…The preparates were centrifuged at +4 °C and 10000 x g for 10 minutes. The supernatants were collected for determining biochemical parameters as described previously in our study [8][9][10] ; reduced glutathione (GSH), lipid peroxidation (LPO), advanced oxidized protein products (AOPP), hydroxy proline (HP), catalase (CAT), carbonic anhydrase (CA), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), total antioxidant capacity (TAC), total oxidant status (TOS), reactive oxygen species (ROS), oxidative stress index (OSI), nitric oxide (NO), xanthine oxidase (XO), lactate dehydrogenase (LDH) superoxide dismutase (SOD), paraoxonase (PON) and lung protein levels were determined. Histological Analyses: F or light microscopic investigations, after fixing in 10% neutral buffered formaldehyde, lung samples were processed routinely before embedding in paraffin.…”

Section: Preparation Of White Cabbage Aqueous Extract (Wcae)mentioning

confidence: 99%

Protective Role of White Cabbage Extract Against Amiodarone-Induced Lung Damage in Rats

Türkyılmaz

MUHAN

et al. 2022

Online Türk Sağlık Bilimleri Dergisi

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Bu çalışmada amiodar on'un sebep olduğu akciğer hasarında beyaz lahananın koruyucu etkileri araştırılmıştır. Materyal ve Metot: Bu çalışmada, sıçanlar 4 gr uba ayrılmıştır. Kontrol grup: dokunulmamış sıçanlar, WCAE grup, sıçanlara 7 gün 500 mg/kg beyaz lahana ekstraktı verildi; AMD grup, sıçanlara 7 gün 100 mg/kg amiodaron (AMD) verildi; AMD+WCAE grup, sıçanlara aynı dozlarda beyaz lahana ekstraktı ve AMD verildi. Bulgular: AMD+WCAE gr ubunda, beyaz lahana ekstraktı tedavisi interstisyal ödem ve konjesyonun azalmasına, alveolar yapılarda iyileşme ve bunun yanı sıra parankimdeki enflamatuvar hücre infiltrasyonun gerilemesine sebep olmuştur. Ek olarak, AMD+WCAE grubunda parankimde kollajen liflerinin birikmesinde önemli derecede bir azalma görülmüştür. Akciğerdeki glutatyon seviyesi, total antioksidan kapasitesi ve glutatyon-S-transferaz, paraoksonaz and karbonik anhidraz aktiviteleri azalırken, lipit peroksidasyon, ileri okside protein ürünleri, total oksidan durumu, reaktif oksijen türleri, oksidatif stres indeksi, nitrik oksit ve hidroksiprolin seviyeleri, katalaz, süperoksit dismutaz, glutatyon peroksidaz, glutatyon redüktaz, laktat dehidrogenaz and ksantin oksidaz aktiviteleri AMD grubunda artmıştır. Beyaz lahana ekstraktı tedavisi AMD'un neden olduğu bu seviyeleri ve aktiviteleri tersine çevirmiştir. Sonuç: Beyaz lahana ekstr aktının amiodar on'un sebep olduğu akciğer hasarını azaltabileceği sonucuna varabiliriz.

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The effects of edaravone, a free‐radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

Cited by 12 publications

References 89 publications

Protective effect of edaravone on rat testis after valproic acid treatment

Protective effect of edaravone on rat testis after valproic acid treatment

The Effects of Alpha Lipoic Acid on Lens Injury in Rats Administered With Valproic Acid

Protective Role of White Cabbage Extract Against Amiodarone-Induced Lung Damage in Rats

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