The effects of emotional stress are not identical to those of physical stress in mouse model of social defeat stress

Nakatake, Yuko; Furuie, Hiroki; Yamada, Mitsunori; Kuniishi, Hiroshi; Ukezono, Masatoshi; Yoshizawa, Kazumi; Yamada, Mitsuhiko

doi:10.1016/j.neures.2019.10.008

Cited by 24 publications

(24 citation statements)

References 31 publications

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“…We have previously reported that witnessing actual SDS induces avoidance behaviour in the SIT and increases immobility in the FST 10 . In the present study, however, repeated exposure to the SDS video did not affect these parameters.…”

Section: Discussionmentioning

confidence: 93%

“…Rodents are reported to display various stress-related changes when directly witnessing SDS [5][6][7][8][9][10] . It has been suggested that they recognise the emotional state of conspecifics in distress as their own stress, using visual, auditory, and chemosensory stimuli as cues.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it was previously reported that stressed animals also reduced their intake of calorie-free saccharin solutions 32,33 . Furthermore, mice witnessing actual SDS that showed increase in weight gain were also reported to have reduced sucrose preference 10 . Together, these results strongly suggest that exposure to SDS videos has significant effects on reward sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…To prepare the SDS video, we performed SDS experiments according to the standard method for mice SDS models 26 . Prior to the SDS experiment, ICR mice were screened for aggressive behaviours toward C57BL/6J mice according to the screening criteria, which we have previously published 10 . For the SDS experiment, an aggressive ICR mouse was placed into a transparent acrylic cage (10 cm × 23 cm × 12 cm) with their bedding, and a C57BL/6J mouse was then placed into the cage.…”

Section: Sds Video Preparationmentioning

confidence: 99%

“…The FST was performed as previously described 10 . Mice were placed individually into 5 L beakers (27 cm × 19 cm) containing 3.5 L of water (23 ± 1 °C) for 6 min.…”

Section: Forced Swim Test (Fst)mentioning

confidence: 99%

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Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice

Nakatake

Furuie

Ukezono³

et al. 2020

Sci Rep

Self Cite

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Rodents perceive the emotional states of conspecifics using vision. In the present study, we demonstrated that exposure to the video-recorded distress of conspecifics induces stress responses in male C57BL/6J mice. A single exposure to a video-recorded scene of the social defeat stress (SDS) increased plasma corticosterone levels in these mice. This physiological change was suppressed by blocking the visual information, suggesting that vision plays a crucial role in inducing stress responses. Furthermore, after exposure to the video, there were increased numbers of c-Fos-positive neurons in the anterior cingulate cortex and other brain areas that are associated with the negative valence and empathy systems, but not in the regions related to the pain signaling. In addition, repeated exposure to SDS videos induced an apparent reduction in reward sensitivity in the sucrose preference test, but did not affect avoidance behaviour in the social interaction test or immobility behaviour in the forced swim test. Reduced reward sensitivity in mice reflects anhedonia, which is a core symptom of depression in humans. Our video SDS model therefore provides a unique opportunity to not only understand the mechanisms underlying stress-induced anhedonia, but also to screen effective candidate molecules for stress-related disorders with greater reproducibility.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Sds Video Preparationmentioning

confidence: 99%

“…The FST was performed as previously described 10 . Mice were placed individually into 5 L beakers (27 cm × 19 cm) containing 3.5 L of water (23 ± 1 °C) for 6 min.…”

Section: Forced Swim Test (Fst)mentioning

confidence: 99%

See 3 more Smart Citations

Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice

Nakatake

Furuie

Ukezono³

et al. 2020

Sci Rep

Self Cite

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Adolescent stress during, but not after, pubertal onset impairs indices of prepulse inhibition in adult rats

Drzewiecki

Willing

Cortes

et al. 2021

Developmental Psychobiology

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Exposure to stress during adolescence is a risk factor for developing several psychiatric disorders, many of which involve prefrontal cortex (PFC) dysfunction. The human PFC and analogous rodent medial prefrontal cortex (mPFC) continue to mature functionally and anatomically during adolescence, and some of these maturational events coincide with pubertal onset. As developing brain regions are more susceptible to the negative effects of stress, this may make puberty especially vulnerable. To test this, we exposed male and female rats to isolation and restraint stress during the onset of puberty or during the post-pubertal period of adolescence. In young adulthood, both stressed groups and an unstressed control group underwent testing on a battery of tasks to assess emotional and cognitive behaviors, and the volume of the mPFC was quantified postmortem. Factor analysis revealed only subjects stressed peripubertally showed a long-term deficiency compared to controls in prepulse inhibition.Additionally, both sexes showed volumetric mPFC decreases following adolescent stress, and these losses were most pronounced in females. Our findings suggest that pubertal onset may be a vulnerable window wherein adolescents are most susceptible to the negative consequences of stress exposure. Furthermore, it highlights the importance of accounting for pubertal status when studying adolescents.

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Mechanisms of Adaptation of the Hypothalamic-Pituitary-Adrenal Axis in Male Mice in Chronic Social Defeat Stress

Sapronova,

Ryabushkina,

Kisaretova

et al. 2024

Neurosci Behav Physi

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The effects of emotional stress are not identical to those of physical stress in mouse model of social defeat stress

Cited by 24 publications

References 31 publications

Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice

Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice

Adolescent stress during, but not after, pubertal onset impairs indices of prepulse inhibition in adult rats

Mechanisms of Adaptation of the Hypothalamic-Pituitary-Adrenal Axis in Male Mice in Chronic Social Defeat Stress

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