Objective: To carry out a theoretical reflection on how fake news related to the COVID-19 pandemic had an impact on health and nursing care. Method: theoretical-reflective study about fake news related to the COVID-19 pandemic and the impact on health and nursing care. To search for articles/texts, the descriptors Fake News, COVID-19, Coronavirus Infections, Health Repercussions extracted from Descriptors in Health Sciences (DeCS) and Medical Subject Headings (MeSH) were used in Portuguese and English. and the keyword Repercussions in Nursing. The search took place in scientific databases and databases, with a thorough reading of articles related to the theme. Results and Discussion: Three guiding points/categories were elaborated to support the theoretical-reflective text of this article: “The Fake News in the COVID-19 pandemic”; “Some interferences of Fake News in the population”, with four subdivided categories and the last category “The impact on nursing care.” Final considerations: discrediting the recommendations of health professionals, especially nurses, had an impact on their health due to the stress they experienced, the disrespect and the violence they suffered, in the face of disbelief in relation to the correct guidelines that they verbalized and followed. It is understood that educational programs to stimulate critical thinking and online behavior are important strategies for the management of Fake News, helping to further prevent the dissemination of erroneous information about relevant topics related to the pandemic.