Aiming at production environment and operation design in manual materials handling which often overlook workers' physiological factors and cause fatigue, even work-related musculoskeletal disorders, we construct a biobjective model based on economics and ergonomics. In the model, two objectives include functions about handling time and energy consumption. Based on the openness of IGRIP/ERGO simulation software combined with MATLAB, we design and develop the interactive simulation platform, where program language can be automatically generated. Then, we analyze the case about handling operations in an automobile brake pad manufacturing company, and the number of input materials and process scheduling are taken as research objects. Finally, the results show that the win-win optimal solution can be usually obtained between productivity and ergonomics for decision makers according to the proposed biobjective model. Moreover, the case study demonstrates that the interactive simulation platform can be devoted to providing the solution for modern production operation directly and conveniently, which can make the production environment and operation design in accordance with ergonomics.