Addressing climate change and improving air quality are prominent tasks facing China’s ecological environment. The synergistic emission reduction in greenhouse gases (GHGs) and air pollutants has become an important task of environmental governance in different provinces. In this study, Hebei Province was taken as the research object. Firstly, the emission factors of GHGs (CO2, CH4, and NO2) and air pollutants (SO2, NOX, and smoke & dust) in Hebei Province from 2011 to 2020 were calculated and analyzed. Seven socio-economic indicators were selected to analyze the trend during the study period. The Spearman rank correlation coefficient method was used to analyze the correlation between GHG and air pollutant emissions. Finally, the synergistic control effect coordinate system and the cross-elasticity coefficient of emission reduction were used to study the synergistic emission reduction effect of GHGs and air pollutants. The results showed that the total amount of GHG emissions fluctuated slightly from 2011 to 2020, and energy activities were the main source of total GHG emissions. The total emissions of air pollutants decreased year by year, and decreased by 71.13% in 2020 compared with 2011. During the study period, the emission synergy between smoke & dust and GHG was better than that between SO2, NOX, and GHG. GHG and SO2, NOX, and smoke & dust achieved synergistic emission reduction in most years, but the overall emission reduction synergy was poor.