2015
DOI: 10.1007/s12013-015-0676-7
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The Effects of Ephedrine and Phenylephrine on Placental Vascular Resistance During Cesarean Section Under Epidual Anesthesia

Abstract: The purpose of this article is to study the effect of ephedrine and phenylephrine on placental vascular resistance during cesarean section under epidural anesthesia via Doppler ultrasonography. Sixty female subjects, scheduled for elective cesarean section and had an intrathecal injection of bupivacaine, were randomly divided into two groups to receive phenylephrine (50 μg/min) or ephedrine (4 mg/min) via titration to maintain systolic blood pressure at baseline. Doppler ultrasonography was used to measure bas… Show more

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Cited by 14 publications
(16 citation statements)
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“…Alahuhta et al compared the effects of phenylephrine and ephedrine infusions on uteroplacental vascular resistance during spinal anesthesia in healthy parturients and observed a significant increase in the PI of uterine and placental arcuate arteries with phenylephrine administration, though no significant change from baseline with ephedrine (18). Recently, Guo et al examined the effects of phenylephrine or ephedrine infusion on placental vascular resistance during spinal anesthesia and observed no significant differences in the umbilical artery or uterine artery vascular resistance, though the uterine arterial vascular resistance was elevated from baseline in both study groups (25). No significant differences in fetal acid–base status or clinical outcomes were noted between phenylephrine and ephedrine study groups in either study (18, 25).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Alahuhta et al compared the effects of phenylephrine and ephedrine infusions on uteroplacental vascular resistance during spinal anesthesia in healthy parturients and observed a significant increase in the PI of uterine and placental arcuate arteries with phenylephrine administration, though no significant change from baseline with ephedrine (18). Recently, Guo et al examined the effects of phenylephrine or ephedrine infusion on placental vascular resistance during spinal anesthesia and observed no significant differences in the umbilical artery or uterine artery vascular resistance, though the uterine arterial vascular resistance was elevated from baseline in both study groups (25). No significant differences in fetal acid–base status or clinical outcomes were noted between phenylephrine and ephedrine study groups in either study (18, 25).…”
Section: Resultsmentioning
confidence: 99%
“…Recently, Guo et al examined the effects of phenylephrine or ephedrine infusion on placental vascular resistance during spinal anesthesia and observed no significant differences in the umbilical artery or uterine artery vascular resistance, though the uterine arterial vascular resistance was elevated from baseline in both study groups (25). No significant differences in fetal acid–base status or clinical outcomes were noted between phenylephrine and ephedrine study groups in either study (18, 25). Ngan Kee et al investigated the effects of ephedrine and metaraminol on uterine vascular resistance in healthy parturients undergoing elective cesarean section.…”
Section: Resultsmentioning
confidence: 99%
“…The unsuccessful parturients will be excluded from the study. For unsuccessful parturients, an epidural injection of 2% lidocaine (3 mL, test dose) +0.75% ropivacaine (12 mL) will be given (3 mL/5 min) until the sensory block level is higher than T8 (total volume will be less than 15 mL) 7 29 or the anaesthetic technique will be changed into general anaesthesia.…”
Section: Methods and Analysismentioning
confidence: 99%
“…The prophylactic use of fluid (crystalloid 7 or colloid 8 ) and/or vasopressors (phenylephrine 9 or ephedrine 7 ) is usually applied to decrease maternal hypotension. However, the blood volume of the parturient is obviously increased in the later trimesters of pregnancy.…”
Section: Introductionmentioning
confidence: 99%
“…The influence of ephedrine and phenylephrine on systolic blood pressure under spinal anesthesia was found to be equal, for both agents [11]. Furthermore, investigations on the effect of either of ephedrine and phenylephrine on placental vascular resistance did not detect any differences and supported the equal value for both of them [15]. Also, no differences were observed between the effect of ephedrine and phenylephrine on chemical components of umbilical arterial and venous [13].…”
Section: Biomedical Research 2018; 29 (8): 1527-1531mentioning
confidence: 98%