The Effects of Erdosteine on Lung Injury Induced by the Ischemia-Reperfusion of the Hind-Limbs in Rats

α-Lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine

“…Moreover, the NO produced during infl ammation is converted to a peroxynitrite anion that may harm distant organs. 1,2,27 Cells undergo specifi c changes in enzyme activities, mitochondrial function, cytoskeletal structure, membrane transport, and antioxidant defenses in response to hypoxia, which collectively predispose to reoxygenation injury. It is well known that reperfusion worsens ischemic injury by increasing ROS, RNS including peroxynitrite (ONOO), and ROS/RNS peroxidize membrane lipids, oxidizing DNA, and denaturing enzyme proteins, which lead to cellular injury.…”

Erdosteine and Ebselen As Useful Agents in Intestinal Ischemia/Reperfusion Injury

“…It is of importance in situations such as the interruption of blood flow to the intestine as in abdominal aortic aneurysm surgery, cardiopulmonary bypass, strangulated hernias, neonatal necrotizing enterocolitis, and intestinal transplantation [1][2][3]. Intestinal I/R also occurs in severe burns and septic and hypovolemic shock [4,5].…”

“…Such reactions lead to excessive ROS generation, such as superoxide (·O 2 Ϫ ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (·OH), which have the capability to damage the cell membrane through lipid peroxidation and protein oxidation [2,7]. These oxygen metabolites and enzymes of neutrophils also cause serious damage to the surrounding tissue and distant organs by direct and indirect injury to the vascular endothelium [1,4,8].…”

Protective effect of erdosteine on erythrocyte deformabilityin a rat model of lower limb ischemia/reperfusion injury

“…Metabolites of erdosteine have two sulfhydryl groups and they take part in free radical scavenging and antioxidant activity (13). Free radical scavenging properties of erdosteine have been shown in experimental and clinical studies (1,6,7,11).…”