The Effects of Estrogens on the Bone Marrow of Adult Female Dogs

Abstract

Large doses of estrogens have a profound effect on the bone marrow of adult dogs. The initial reaction is a great increase in the number of neutrophilic elements in the bone marrow. These neutrophils are released into the blood stream causing a marked rise in the total white cell count. This is followed by congestion of the bone marrow and a destruction of the white cell elements in these marrows. Congested areas and locations formerly occupied by white cell elements are replaced by edema, leaving erythroid elements intact. This accounts for the marked drop in the total white cell count in the blood stream. This is followed by destruction of remaining erythroid elements in the bone marrow and replacement by "edema" until a stage is reached where practically no cells can be found in the marrow.

Adaptation of Hemopoietic Tissue Resulting From Estrone‐induced Osteosclerosis in Mice

“…1973). marrow hypoplasia and aplasia (Crafts. 1948: Tyslowitz & Dingemanse, 1941), leukopenia (Fried, 1973, inhibition of mbeloid differentiation (Jenkins, Upton &Odell.…”

Some Conditions Associated with Variations in Circulating Oestrogens—Blood Picture Alterations

“…High doses of oestrogens given experimentally to dogs have been shown to cause violent alterations in the blood picture of these animals (Arnold et al 1936;Arnold et al 1937;Tislowitz, 1938;Arnold, 1939;Tislowitz, 1939;MacBryde et al, 1940 andCrafts, 1948). The red cell counts fall while the white cell counts rise rapidly and then fall away to very low levels due to the toxic effects of large doses of oestrogens.…”

Malignant seminoma with gross metastases in a dog

“…Biochemical and haematological abnormalities associated with seminomas may include aplastic anaemia, leucopenia (Morgan 1982), elevated serum levels of alkaline phosphatase, cholesterol, total proteins and lactate dehydrogenase (Weller and Palmer 1983). The myelosuppression noted by Morgan (1982) resembles that reported for oestrogen-induced anaemia (Castradale and others 1941, Crafts 1948, Steinberg 1970 and might reflect the increased amounts of oestrogens that may be found in association with seminomas (Comhaire and others 1974). Serum a-fetoprotein (AFP), a tumour-associated protein, may have been the cause of the elevation in plasma protein levels associated with metastatic seminoma (Weller and Palmer 1983), although AFP was not measured in this dog.…”