The Effects of Exercise on Long-Term Potentiation: A Candidate Mechanism of the Exercise-Memory Relationship

Loprinzi, Paul D.

doi:10.21926/obm.neurobiol.1902026

Cited by 23 publications

(19 citation statements)

References 47 publications

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“…We have extensively demonstrated that acute exercise [1,2], particularly high-intensity exercise [3], can enhance memory function, including episodic memory [4,5] and working memory capacity [6]. Mechanisms of this effect can be found elsewhere [7,8,9,10,11], and include, for example, increased neuronal excitability in key memory-related brain structures (e.g., hippocampus) [12]. What has been considerably less investigated, however, is whether acute exercise can effectuate intentional forgetting.…”

Section: Introductionmentioning

confidence: 99%

High-Intensity Acute Exercise and Directed Forgetting on Memory Function

Pace

Loprinzi

2019

Medicina

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Background and Objectives: Despite accumulating research demonstrating that acute exercise may enhance memory function, very little research has evaluated whether acute exercise can effectuate intentional directed forgetting (DF), an adaptative strategy to facilitate subsequent memory performance. Materials and Methods: A three-arm parallel-group randomized controlled intervention was employed. Participants were randomized into one of three groups, including: (1) exercise plus DF (Ex + DF), (2) DF (directed forgetting) only (DF) and (3) R (remember) only (R). The acute bout of exercise included 15 min of high-intensity treadmill exercise. The memory assessment involved the presentation of two-word lists. After encoding the first word list, participants were either instructed to forget all of those words (DF) or to remember them. Following this, participants encoded the second word list. Results: We observed a statistically significant main effect for list F(1, 57) = 12.27, p < 0.001, η2p = 0.18, but no main effect for group F(2, 57) = 1.32, p = 0.27, η2p = 0.04, or list by group interaction, F(2, 57) = 2.89, p = 0.06, η2p = 0.09. Conclusion: This study demonstrates a directed forgetting effect in that cueing an individual to forget a previously encoded list of items facilitates memory performance on a subsequent list of items. However, we failed to demonstrate any beneficial effect of acute exercise in facilitating directed forgetting. These findings are discussed in the context of directed forgetting theories, particularly the attention inhibition mechanism, as well as the timing of the acute bout of exercise.

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Section: Introductionmentioning

confidence: 99%

High-Intensity Acute Exercise and Directed Forgetting on Memory Function

Pace

Loprinzi

2019

Medicina

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“…The present study, written as a brief report, aimed to evaluate whether acute exercise can enhance a cognitive-related reversal learning effect. The motivation for this experimentation came from past work demonstrating that acute exercise can enhance the functional connectivity of neurons [32], improve cognitive flexibility [15][16][17], as well as improve memory function [1][2][3][4][5][6][7], all of which are important for cognitive-related learning. In the present experiment, our main findings were as follows.…”

Section: Discussionmentioning

confidence: 99%

Acute Exercise on Reversal Learning

Sanderson¹,

Loprinzi²

2019

obm neurobiol

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Objective: Reversal learning requires an individual to alter their behavior when previously learned reward-based contingencies are reversed. Reversal learning is heavily influenced by cognitive flexibility, which has been shown to be enhanced with acute exercise. However, minimal work has directly evaluated the effects of acute exercise on reversal learning, which was the purpose of this experiment. Methods: A between-subject randomized controlled intervention was employed. Participants (N=60) were randomized into one of three groups, including a control group, moderate-intensity exercise and vigorous-intensity exercise. The exercise bout lasted 15-min in duration.

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“…Acute exercise during both of these time periods may activate unique mechanisms to enhance long-term memory. For example, as thoroughly detailed elsewhere [18,21], acute exercise prior to memory encoding may induce neuronal excitability in key memory structures (e.g., hippocampus), ultimately facilitating long-term potentiation [15], or enhanced communication across neurons. Further, acute exercise prior to memory encoding may increase psychological arousal, which may help facilitate memory encoding via enhanced attention on the task [21].…”

Section: Introductionmentioning

confidence: 99%

Does Engaging in Acute Exercise Prior to Memory Encoding and During Memory Consolidation have an Additive Effect on Long-Term Memory Function?

Loprinzi

Chism

Marable

2019

J. of SCI. IN SPORT AND EXERCISE

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Previous work has demonstrated that acute exercise prior to memory encoding may enhance long-term memory. Similarly, other work demonstrates that acute exercise during the memory consolidation period may also enhance long-term memory function. However, no study has evaluated whether long-term memory is enhanced when an acute bout of exercise occurs during both of these time periods, when compared to just prior to memory encoding. A within-subject randomized controlled intervention was employed. On separate laboratory visits, participants completed two main protocols, including (1) exercise before memory encoding and (2) exercise before and after memory encoding. Long-term memory was assessed, via a word-list task, from a 20-min delay period and a 24-h delay period. We observed a significant main effect for time, F(8, 176) = 529.5, P < 0.001, η p 2 = 0.96, but no significant main effect for condition, F(1, 22) = 0.08, P = 0.77, η p 2 = 0.004, or time by condition interaction, F(8, 176) = 0.19, P = 0.99, η p 2 = 0.009. In conclusion, there was no difference in long-term memory function when comparing acute exercise only prior to memory encoding vs. acute exercise both before and immediately after memory encoding.

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The Effects of Exercise on Long-Term Potentiation: A Candidate Mechanism of the Exercise-Memory Relationship

Cited by 23 publications

References 47 publications

High-Intensity Acute Exercise and Directed Forgetting on Memory Function

High-Intensity Acute Exercise and Directed Forgetting on Memory Function

Acute Exercise on Reversal Learning

Does Engaging in Acute Exercise Prior to Memory Encoding and During Memory Consolidation have an Additive Effect on Long-Term Memory Function?

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