The effects of exercise training on inflammatory biomarkers in patients with breast cancer: A systematic review and meta-analysis

Abbasi, Fatemeh; Pourjalali, Hanieh; Nascimento, Israel Júnior Borges do; Zargarzadeh, Nikan; Mousavi, Seyed Mohammad; Eslami, Rasoul; Milajerdi, Alireza

doi:10.1016/j.cyto.2021.155712

Cited by 20 publications

(12 citation statements)

References 47 publications

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“…In accordance with our data, the previous systematic review by Abbasi et al (2022) reported a significant reduction in CRP levels following the physical exercise in BC survivors; however, the authors failed to find significant changes in other relevant inflammation biomarkers, including TNF-α, IL-6, IL-8, IL-10, INF-ɣ, and IL-1β. However, the authors performed a quantitative data synthesis without characterizing different exercise modalities.…”

Section: Discussionsupporting

confidence: 91%

“…However, the authors performed a quantitative data synthesis without characterizing different exercise modalities. Moreover, the authors did not exclude patients with advanced or metastatic cancers, with significant implications in terms of inflammatory states, exercise load tolerability, and physical exercise response ( Abbasi et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

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Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials

Invernizzi

Lippi

Folli

et al. 2022

Front. Mol. Biosci.

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Background: Quality of life issues is a crucial burden in breast cancer (BC) survivors with relevant implications in terms of survivorship and health-care costs. The increasing long-term survival of these patients provides new challenges, with translational research now focusing on innovative and tailored approaches to improve their complex management. In this scenario, several emerging biomarkers have the potential to improve the clinical rehabilitative management of patients with BC. However, to date, guidelines supporting biomarker implementation in this area are still lacking. Therefore, the aim of this systematic review was to summarize the currently available biomarkers that might be potentially integrated into rehabilitation practice to promote a precision medicine approach to BC survivorship issues.Methods: On 9th March 2022, PubMed, Scopus, Web of Science, Cochrane, and PEDro were systematically searched for randomized controlled trials (RCTs) assessing rehabilitation interventions in BC patients. Molecular biomarker modifications induced by physical exercise have been assessed through the review of the study protocols and published results. The Jadad scale was used to assess the quality of the studies included.Results: Out of 2,224 records, 22 studies were included in the present systematic review. Exercise therapy showed significant results in 15 RCTs, in terms of metabolic biomarkers, including glycemic and insulin profile, and lipid profile (p ≤ 0.05). Similarly, 12 studies underlined significant effects in inflammation and immune response biomarkers, including TNF-α, IL-6, IL-10, C-reactive protein, leptin, and adiponectin (p ≤ 0.05). On the other hand, cardiac biomarkers were assessed in three studies without reporting significant differences after exercise therapy (p = NS). The quality assessment identified 19 RCTs as high-quality studies and three RCTs of low quality.Conclusion: Our findings reveal significant biochemical perturbations in key molecules induced by physical exercise in patients with BC, suggesting room for the implementation of actionable biomarkers. Future research might clarify the role of biomarkers on treatment effectiveness monitoring, to optimize rehabilitative strategies tailored to patient’s needs.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials

Invernizzi

Lippi

Folli

et al. 2022

Front. Mol. Biosci.

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“…Recent shreds of evidence have also unveiled several biomarkers (e.g., inflammatory molecules, mitochondria modifications) (62,63) with monitoring potential to improve the clinical rehabilitative management of BC patients. Interestingly, these actionable biomarkers were shown to be modulated by PE (64), opening the possibility of targeted control of the therapeutic effect of PE on BC survivors. Future studies should also envisage deciphering the biological mechanisms by which PE potentiates an improvement of the QoL in BC patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of physical exercise programs in breast cancer survivors on health-related quality of life, physical fitness, and body composition: Evidence from systematic reviews and meta-analyses

et al. 2022

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BackgroundBreast cancer is the most common cancer worldwide, and despite remarkable progress in its treatment, the survivors’ quality of life is hampered by treatment-related side effects that impair psychosocial and physiological outcomes. Several studies have established the benefits of physical exercise in breast cancer survivors in recent years. Physical exercise reduces the impact of treatment-related adverse events to promote a better quality of life and functional outcomes.AimThis study aims to provide an overview of systematic reviews and meta-analyses on the effect of physical exercise on the health-related quality of life, cardiorespiratory fitness, muscle strength, and body composition of breast cancer survivors.MethodsPubMed and Cochrane databases were searched for systematic reviews and meta-analyses from January 2010 to October 2022. The main focus was ascertaining the effectiveness of physical exercise in breast cancer survivors undergoing curative treatment (surgery and/or radiotherapy and/or chemotherapy). Two reviewers independently screened the literature, extracted the data, and assessed the risk of bias in the included studies.ResultsA total of 101 studies were identified, and 12 were yielded for final analysis. The eligible studies included nine systematic reviews/meta-analyses, one meta-analysis/meta-regression, and two systematic reviews. The number of randomised clinical trials included in each review varied from 11 to 63, and the number of participants was from 214 to 5761. A positive and significant effect of different physical exercise interventions on health-related quality of life was reported in 83.3% (10 studies) of the eligible studies. Physical exercise also improved cardiorespiratory fitness (3 studies; 25%) and showed to be effective in reducing body weight (3 studies; 25%) and waist circumference (4 studies; 33.3%).ConclusionsOur results suggest that physical exercise is an effective strategy that positively affects breast cancer survivors’ quality of life, cardiorespiratory fitness, and body composition. Healthcare professionals should foster the adoption of physical exercise interventions to achieve better health outcomes following breast cancer treatments.Systematic review registrationhttps://inplasy.com/inplasy-2022-11-0053/, identifier INPLASY2022110053.

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“…Although the degree of satisfaction is high associated with OS, the look under the functional part is little discussed, and me must take care evaluating sequelae and functional functioning. Also, the impact of rehabilitation ( 80 ) and exercise ( 81 ) in OS is under reported. Future reviews evaluating these conditions are necessary.…”

Section: Discussionmentioning

confidence: 99%

Does breast oncoplastic surgery improve quality of life?

2023

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Breast Oncoplastic Surgery (OS) has established itself as a safe procedure associated with the treatment of breast cancer, but the term is broad, encompassing procedures associated with breast-conserving surgeries (BCS), conservative mastectomies and fat grafting. Surgeons believe that OS is associated with an increase in quality of life (QOL), but the diversity of QOL questionnaires and therapeutic modalities makes it difficult to assess from the patient’s perspective. To answer this question, we performed a search for systematic reviews on QOL associated with different COM procedures, and in their absence, we selected case-control studies, discussing the main results. We observed that: (1) Patients undergoing BCS or breast reconstruction have improved QoL compared to those undergoing mastectomy; (2) In patients undergoing BCS, OS has not yet shown an improvement in QOL, a fact possibly influenced by patient selection bias; (3) In patients undergoing mastectomy with reconstruction, the QoL results are superior when the reconstruction is performed with autologous flaps and when the areola is preserved; (4) Prepectoral implants improves QOL in relation to subpectoral implant-based breast reconstruction; (5) ADM do not improves QOL; (6) In patients undergoing prophylactic mastectomy, satisfaction is high with the indication, but the patient must be informed about the potential complications associated with the procedure; (7) Satisfaction is high after performing fat grafting. It is observed that, in general, OS increases QOL, and when evaluating the procedures, any preservation or repair, or the use of autologous tissues, increases QOL, justifying OS.

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The effects of exercise training on inflammatory biomarkers in patients with breast cancer: A systematic review and meta-analysis

Cited by 20 publications

References 47 publications

Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials

Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials

Impact of physical exercise programs in breast cancer survivors on health-related quality of life, physical fitness, and body composition: Evidence from systematic reviews and meta-analyses

Does breast oncoplastic surgery improve quality of life?

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