The effects of exercise training in a weight loss lifestyle intervention on asthma control, quality of life and psychosocial symptoms in adult obese asthmatics: protocol of a randomized controlled trial

Freitas, Patrícia; Ferreira, Palmira G.; Silva, Analuci Da; Trecco, S Mlss; Stelmach, Rafaël; Cukier, Alberto; Carvalho-Pinto, Regina Maria; Salge, João Marcos; Fernandes, Frederico Leon Arrabal; Mancini, Márcio C.; Martins, Mílton A.; Carvalho, Celso

doi:10.1186/s12890-015-0111-2

Cited by 30 publications

(20 citation statements)

References 75 publications

(96 reference statements)

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“…The possible mechanism for the effect of exercise training on weight loss is to increase metabolic consumption which may subsequently reduce the low‐grade inflammation commonly noted among overweight patients . Because of the pathophysiological synergistic of obesity and haemophilia, weight control in PWH results in better conservation of normal joint function and improved quality of life .…”

Section: Discussionmentioning

confidence: 99%

“…27 The possible mechanism for the effect of exercise training on weight loss is to increase metabolic consumption which may subsequently reduce the low-grade inflammation commonly noted among overweight patients. 36 Because of the pathophysiological synergistic of obesity and haemophilia, weight control in PWH results in better conservation of normal joint function and improved quality of life. 9 According to above-mentioned results, it seems that CT can be prescribed as a starter programme for middle-aged PWH who are overweight or obese to reduce adiposity and improve cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 99%

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The effects of six‐week resistance, aerobic and combined exercises on the pro‐inflammatory and anti‐inflammatory markers in overweight patients with moderate haemophilia A: A randomized controlled trial

et al. 2019

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Introduction Overweight increases the secretion of pro‐inflammatory cytokines and serves as a major risk factor for arthropathy and cardiovascular diseases (CVD). This condition is becoming increasingly prevalent among patients with haemophilia (PWH). Different forms of exercise training could favourably modify weight‐related complications, cardiovascular risk factors and the inflammation. Aim To investigate the effects of resistance, aerobic and combined exercises on the pro‐inflammatory and anti‐inflammatory markers in overweight patients with moderate haemophilia A. Methods Forty‐eight patients with moderate haemophilia A, aged 35‐55 years, and body mass index (BMI) of 25‐30 kg/m2 were randomly assigned to resistance training (RT, n = 12), aerobic (AT, n = 12), combined training (CT, n = 12) and control (n = 12) groups. The patients participated in 45‐minutes exercise sessions three times a week for 6 weeks. Waist circumference (WC), waist‐to‐hip ratio (WHR), fat mass, fat‐free mass, interleukin‐10 (IL‐10), adiponectin, tumour necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and high sensitive C‐reactive protein (hs‐CRP) were measured before and after the 6 weeks of training. Results There was significant decrease in WC, WHR, BMI and weight in the AT, RT and CT groups as compared to the control group. Total HJHS scores decreased in the AT, RT, CT groups compared to the control groups (P ≤ 0.001). The decrease in hs‐CRP, IL‐6 and TNF‐α in the CT group was significant compared to the control group (P ≤ 0.02). The increase in IL‐10 and adiponectin was not significant in the RT, AT and CT groups compared to the control group. Conclusion CT was the most effective training mode for decreasing the pro‐inflammatory cytokines and increasing anti‐inflammatory markers in overweight patients with haemophilia A.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effects of six‐week resistance, aerobic and combined exercises on the pro‐inflammatory and anti‐inflammatory markers in overweight patients with moderate haemophilia A: A randomized controlled trial

et al. 2019

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“…This excess in body mass in comparison to height contributes to a heavier chest wall and larger abdomen leading to increased inspiratory effort. Increased BMI can lead to decreased lung compliance [26] and decreased tidal volumes [27,28].…”

Section: Obesity-associated Asthmamentioning

confidence: 99%

The role of airway hyperresponsiveness measured by methacholine challenge test in defining asthma severity in asthma–obesity syndrome

Charron

Pakhalé²

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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The current literature suggests that improvement in lung function requires moderate to significant (5-10%) weight loss in adults with obesity and asthma. However, with a few exceptions, the majority of these studies were small and used variable and questionable asthma severity outcome measures. There is an urgent need for standardization of diagnosis of asthma, study inclusion criteria, and outcome measures to assess asthma severity in research setting. Long-term effects of weight loss interventions on asthma severity and control, in adults with obesity and asthma, also remain unanswered.

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“…Exercise, in conjunction with dietary and psychological support, has been reported to reduce body weight by 7% in moderate-to-severe asthma patients [55]. Exercise training and weight-loss programmes, when combined, result in increased aerobic capacity and strength, leading to better clinical control of asthma and improved HRQoL [55].…”

Section: Strategies To Improve Quality Of Lifementioning

confidence: 99%

Living well with severe asthma

Stubbs

Clark

McDonald

2019

Breathe

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Living well with severe asthma can be challenging. People with severe asthma can be refractory to treatment, can experience poor symptom control and are at a heightened risk of death. Patients experience symptoms of shortness of breath, chest tightness, cough and wheeze. These symptoms influence many aspects of an individual's life, resulting in emotional, financial, functional and medication-related burdens that negatively impact quality of life. Quality of life is known to be influenced by individual levels of satisfaction that stem from real-life treatment experiences. This experience is portrayed through the lens of the patient, which is commonly referred to as the patient perspective.The patient perspective is only one element of the patient experience. It influences health status, which, in severe asthma, is commonly assessed using validated health-related quality of life measures. A positive patient perspective may be achieved with implementation of management strategies tailored to individual needs. Management strategies developed in partnership between the patient, the severe asthma multidisciplinary team and the general practitioner may minimise disease-related impairment, allowing patients to live well with severe asthma.Key pointsDespite advances in treatment over the past decade, the experience of living with severe asthma has not significantly improved, with high levels of burden influencing the patient perspective.The impact of severe disease is not only restricted to asthma symptoms and acute attacks. It causes significant emotional, financial, functional and medication-related burdens, leading to impaired health-related quality of life.Clinical outcomes should not be stand-alone measures in severe asthma. Nonclinical measures should also be considered when evaluating health-related quality of life.Disease burden may be minimised and quality of life improvedviaself-management strategies, including education sessions, written asthma action plans, symptom monitoring, breathing exercises, physical activity and psychotherapeutic interventions.Educational aimsTo demonstrate the importance of the patient perspective in severe asthma.To identify the significant levels of disease burden associated with severe asthma.To discuss quality of life in severe asthma.To outline strategies that increase well-being in severe asthma.

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The effects of exercise training in a weight loss lifestyle intervention on asthma control, quality of life and psychosocial symptoms in adult obese asthmatics: protocol of a randomized controlled trial

Cited by 30 publications

References 75 publications

The effects of six‐week resistance, aerobic and combined exercises on the pro‐inflammatory and anti‐inflammatory markers in overweight patients with moderate haemophilia A: A randomized controlled trial

The effects of six‐week resistance, aerobic and combined exercises on the pro‐inflammatory and anti‐inflammatory markers in overweight patients with moderate haemophilia A: A randomized controlled trial

The role of airway hyperresponsiveness measured by methacholine challenge test in defining asthma severity in asthma–obesity syndrome

Living well with severe asthma

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