The effects of exercise training on sympathetic neural activation in advanced heart failure

Roveda, Fabiana; Middlekauff, Holly R.; Rondon, Maria Urbana Pinto Brandão; Reis, Soraya F.; Soeiro-de-Souza, Márcio Gerhardt; Nastari, Luciano; Barretto, Antônio Carlos Pereira; Krieger, Eduardo Moacyr; Negräo, Carlos Eduardo

doi:10.1016/s0735-1097(03)00831-3

Cited by 326 publications

(301 citation statements)

References 29 publications

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“…Signals were amplified by a factor of 50 000 to 100 000 and bandpassed filtered (700 to 2000 Hz). Nerve activity was rectified and integrated (time constant 0.1 s) to obtain a mean voltage display as previously described 22. Muscle sympathetic bursts were expressed as burst frequency (bursts per minute), and burst incidence (bursts per 100 heart beats).…”

Section: Methodsmentioning

confidence: 99%

Cardiac and peripheral autonomic control in restrictive cardiomyopathy

et al. 2017

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AimsAutonomic dysfunction determines the advance of dilated cardiomyopathy (DCM) and is related to poor outcomes. However, this autonomic imbalance is unknown in patients with restrictive cardiomyopathy (RCM) even though they have similar symptoms and poor quality of life as DCM patients have. The aim of this study was to evaluate if autonomic and neurovascular controls were altered in RCM patients.Methods and resultsFifteen RCM patients, 10 DCM patients, and 10 healthy subjects were evaluated. Heart rate and blood pressure (BP) were recorded. Peripheral sympathetic activity [muscle sympathetic nerve activity (MSNA)] by microneurography and cardiac sympathetic activity by power spectrum analysis of heart rate variability. Spontaneous baroreflex sensitivity (BRS) was evaluated by the sequence method and forearm blood flow by venous occlusion plethysmography. Both cardiomyopathy groups had higher MSNA frequency (P < 0.001) and MSNA incidence (P < 0.001), higher cardiac sympathovagal balance (P < 0.02), reduced BRS for increase (P = 0.002) and for decrease in BP (P = 0.002), and lower forearm blood flow (P < 0.001) compared with healthy subjects. We found an inverse correlation between BRS for increase and decrease in BP and peripheral sympathetic activity (r = −0.609, P = 0.001 and r = −0.648, P < 0.001, respectively) and between BRS for increase and decrease in BP and cardiac sympathetic activity (r = −0.503, P = 0.03 and r = −0.487, P = 0.04, respectively).ConclusionsThe RCM patients had cardiac and peripheral autonomic dysfunctions associated with peripheral vasoconstriction. Nonetheless, the presence of normal ejection fraction underestimates the evolution of the disease and makes clinical treatment difficult. These alterations could lead to a similar cardiovascular risk as that observed in DCM patients.

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Section: Methodsmentioning

confidence: 99%

Cardiac and peripheral autonomic control in restrictive cardiomyopathy

et al. 2017

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“…These effects include reduction of sympathetic outflow in exercised humans (14,15) and animals (16)(17)(18) with HF. The sympathetic toxicity of cardiac (17)(18)(19)(20)(21) and skeletal (22)(23)(24) muscles in HF is also reduced by exercise training.…”

Section: Effects Of Exercise Training On the Sympathetic Nervous Systemmentioning

confidence: 99%

Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function

Brum

Bacurau

Medeiros

et al. 2011

Braz J Med Biol Res

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Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.

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“…Como consequência, ocorrem crescentes limitações físicas, psicológicas e sociais, que dificultam a realização das atividades cotidianas (5) e da qualidade de vida (QV) (6). Sendo assim, a reabilitação cardiopulmonar e metabólica (RCPM) configura-se como tratamento decisivo para a melhora da QV (7)(8)(9)(10)(11), principalmente por aumentar a tolerância aos esforços (12,13).…”

Section: Introductionunclassified

“…Dentre os benefícios proporcionados pela RCPM em pacientes com IC, destacam-se melhoras na circulação sanguínea periférica (12), na estrutura muscular esquelética e na capacidade funcional (CF) (10,11,13); o retorno precoce ao trabalho; o aumento da capacidade aeróbia (9,14,15); e benefícios no âmbito social (16,17). Convém ressaltar que o exercício promove a melhora da disfunção endotelial e da capacidade oxidativa do músculo esquelético (14,18) e redução da exacerbação neuro-humoral, que são aspectos de grande relevância na fisiopatologia da síndrome (13,17).…”

Section: Introductionunclassified

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Capacidade funcional como preditor de qualidade de vida na insuficiência cardíaca

et al. 2013

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Fisioter Mov. 2013 set/dez;26(4):página 845-53 doi: ISSN 0103-5150 Fisioter. Mov., Curitiba, v. 26, n. 4, p. página 845-853, set./dez. 2013 Licenciado sob uma Licença Creative Commons [T] Capacidade funcional como preditor de qualidade de vida na insuficiência cardíaca [I] Functional capacity as a predictor of quality of life in heart failure [A] Anderson Zampier Ulbrich [a] , Almir Schmitt Netto [b] , Vitor Giatte Angarten [ [K]

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The effects of exercise training on sympathetic neural activation in advanced heart failure

Abstract: These findings demonstrate that exercise training in heart failure patients results in dramatic reductions in directly recorded resting sympathetic nerve activity. In fact, MSNA was no longer greater than in trained, healthy controls.

Cited by 326 publications

References 29 publications

Cardiac and peripheral autonomic control in restrictive cardiomyopathy

Cardiac and peripheral autonomic control in restrictive cardiomyopathy

Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function

Capacidade funcional como preditor de qualidade de vida na insuficiência cardíaca

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