The Effects of Exogenous Nitric Oxide Donor on Motor Functional Recovery of Reperfused Peripheral Nerve

“Out of Touch”—Recovering Sensibility after Burn Injury: A Review of the Literature

“…Regaining sensibility in most, if not all, sensory quality aspects and, thus, rediscovering their "touch" plays, in the authors' opinion, a key role in the reintegration of their body image in their everyday life. Possible points of action in the future, representing a valuable adjunct in the treatment of post-burn neuropathy and, most possibly, booster nerve regeneration, could be picked up from the experimental animal studies, which aim to booster nerve regeneration by exogenous-applied substances such as Fujimucin, nerve growth factor, brain-derived nerve factor, recombinant human glial growth factor, nitric oxide and interleukin 1 beta [35,37,[39][40][41][42][43], and/or utilizing fibroblast-enriched human skin grafts for more efficiently targeted nerve regrowth.…”

Inhibition of Inducible Nitric Oxide Synthase Promotes Recovery of Motor Function in Rats After Sciatic Nerve Ischemia and Reperfusion

“…55 Hypoxia/reoxygenation down-regulates nNOS mRNA and immunoreactivity in cultured cortical cells. 56 Recently we found that exogenous NO donor promotes motor functional recovery and muscle contractile force in I/R rat sciatic nerve, 35 suggesting that nNOS is beneficial in PNS I/R injury. This differs from cerebral I/R, in which nNOS is up-regulated during reperfusion 57 and is thought to be detrimental.…”

“…46 Our results also parallel those found in skeletal muscle I/R injury treated with 1400W 30 -32 and in iNOS-knockout mice. 35 Thus inhibition of iNOS appears to be a potential therapeutic strategy for the treatment of peripheral nerve I/R injury.…”

“…By using a walking track test the motor function of the rats was evaluated at days 1,7,11,14,18,21,25,28,35, and 42 of reperfusion (19 rats for each group). This procedure has been described previously.…”

(iii) Peripheral nerve repair

“…57 Nitric oxide, when administered to rats after an ischaemic injury to the rat sciatic nerve, showed an improvement in histology and functional recovery when compared to controls or steroids. 58 Ultimately, peripheral nerve injuries have a critical impact on patients' lives and functioning. Sound microsurgical technique as well as a tension-free repair is an important factor in a successful outcome.…”