A field experiment was conducted to study the effect of various doses of fertilizer on the yield and yield components of cotton. The experiment was conducted at farmer's field sites during the year 2015 and 2016 of Bahawalnagar District. The experiment was laid out in Randomized Complete Block Design (RCBD) with three replications. The different doses of fertilizer NPK i.e (280-57-92, 340-85-92 and 400-114-92) significantly affected the plant population/m 2 , plant height (cm), number of mature bolls/plant, seed cotton boll weight (g), and seed cotton yield kg/ha. The various doses of fertilizer was significantly affected almost all the characters related to growth and yield of B.T cotton variety MNH-886. The average of two years result revealed that significant maximum plant population/m 2 i.e 6.8, plant height (cm) i.e 163.1, number of bolls/plant i.e 39.1, boll weight (g) i.e 2.9 and maximum seed cotton yield i.e 2603.0 kg/ha was obtained when fertilizer was applied @ 400-114-92 kg/ha.