The Effects of Feedback Loops and Signalling Complexes in the Induction of Postsynaptic Plasticity: A Systems Biology Approach

Abstract

Synaptic plasticity is the activity-dependent modification of the strength of connections between neurons, which supports learning and memory by selectively strengthening some connections while weakening others. Neural activity generates biochemical signals that activate a complex network of signalling proteins affecting synaptic change by increasing or decreasing the number of receptors present at the synapse. A