The effects of fenoldopam on renal function in patients undergoing elective aortic surgery

Abstract

These findings are consistent with the hypothesis that fenoldopam possesses a renoprotective effect during and after infrarenal aortic cross-clamping.

Acute kidney injury during aortic arch surgery under deep hypothermic circulatory arrest

“…Because AKI is highly associated with aortic surgery, as shown in the present study as well as previous ones, novel approaches for protecting the kidneys other than deep hypothermia are needed. Although efforts to prevent AKI have been made through a variety of drugs [21][22][23][24], a low level of evidence for renal therapeutic intervention has been detected and further study is required. In this context, the standardization of the diagnostic criteria for AKI is mandatory for evaluating the renal outcome, and the present study provides important information.…”

Perioperative fenoldopam for the prevention of acute renal failure in non-cardiac surgery, randomized clinical trial

“…Our results are in accordance with only two previous reports in which fenoldopam was used at a low dosage (9) or for a short period of time. (10) All the other studies (7,8,(13)(14)(15)(16)(17)(18)(19)(20) …”

Nieren-Prophylaxe bei thorakaler Aortenchirurgie

“…Bleibt Fenoldopam, ein selektiver Dopamin-1-Agonist, dem besonders eine Förderung der kortikalen, renalen Durchblutung nachgewiesen wurde [16,17,26]. Auch hier gibt es zum jetzigen Zeitpunkt unterschiedliche Ergebnisse, vor allem von koronarchirurgischen Patienten mit oder ohne präope-rative Nierenfunktionseinschränkung [15,25,26].…”

“…Eine jüngere Arbeit konnte hier zumindest für die Patienten ohne präoperative Nierenfunktionseinschrän-kung keinen Effekt nachweisen [3]. Bei Patienten mit Aortenaneurysmen gibt es, zwar nur für infrarenale Eingriffe, hier aber positive Ergebnisse [17].…”