The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Amini, Mohammad Reza; Payandeh, Nastaran; Sheikhhossein, Fatemeh; Pourreza, Sanaz; Ghalandari, Hamid; Askarpour, Moein; Hekmatdoost, Azita

doi:10.1007/s40292-023-00565-6

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…Nine meta-analyses on fenugreek in MetS or associated conditions have been published in the last ten years [189][190][191][192][193][194][195][196][197]. All of those that assessed effects on blood glucose found a benefit, but concerns were raised about the quality of the clinical trials.…”

Section: Discussionmentioning

confidence: 99%

“…All of those that assessed effects on blood glucose found a benefit, but concerns were raised about the quality of the clinical trials. A review of fenugreek in blood pressure found a dose-dependent effect, with doses greater than 15 g/day for longer than 12 weeks being effective [192]. Neelakantan et al also found that dose impacted the effect of fenugreek on glycaemia, with doses higher than 5 g being effective [189].…”

Section: Discussionmentioning

confidence: 99%

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A Scoping Review of the Clinical Evidence for the Health Benefits of Culinary Doses of Herbs and Spices for the Prevention and Treatment of Metabolic Syndrome

Mackonochie,

Rodriguez-Mateos,

Mills

et al. 2023

Nutrients

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Metabolic syndrome (MetS) is a growing global health problem. Evidence suggests that diets rich in phytochemical-containing herbs and spices can contribute to reducing the risk of chronic diseases. This review assesses the scope of evidence supporting the use of herbs and spices in the diet for the prevention or treatment of MetS and its associated health conditions. A search of the PubMed, Scopus and Google Scholar databases was carried out to assess the available clinical evidence for culinary doses of commonly used herbs and spices. Trials that were measuring health factors related to metabolic disorders in healthy individuals, or the health of individuals with MetS or associated diseases, were included. Out of a total of 1738 papers identified, there were 142 relevant studies on black pepper, chilli, cardamom, cinnamon, coriander, cumin, fennel, fenugreek, garlic, ginger, nigella seed, rosemary, sage and turmeric. No relevant research was found for cloves, mint, oregano, parsley or thyme. Cinnamon, fenugreek and ginger were the herbs/spices with the most published trials on them and that showed promise for glycaemic control. Cardamom appears to have potential to reduce inflammatory markers, and cinnamon, ginger and turmeric to reduce blood lipids. Patients with type 2 diabetes were the population most likely to be included in studies, but the preventative benefits of herbs/spices in healthy populations were also investigated, particularly for chilli, ginger and cinnamon. There is evidence for the beneficial effect of culinary doses of many common herbs/spices in the prevention and treatment of MetS and associated disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Scoping Review of the Clinical Evidence for the Health Benefits of Culinary Doses of Herbs and Spices for the Prevention and Treatment of Metabolic Syndrome

Mackonochie,

Rodriguez-Mateos,

Mills

et al. 2023

Nutrients

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show abstract

“…A recent meta‐analysis of six RCT ( N = 373 participants with prediabetes, metabolic syndrome, or T2D as well as healthy participants) indicated that fenugreek seed supplementation significantly reduced systolic blood pressure, but not diastolic blood pressure. However, subgroup analyses showed that fenugreek seeds administered in dosages ≥15 g/day and durations ≤12 weeks significantly lowered both systolic and diastolic blood pressure (Amini et al., 2023). Similarly, a study conducted with 60 hypertensive participants divided into treatment and control groups showed that the oral administration of sprouted fenugreek seeds for 2 months (dosage not specified) resulted in a significant decrease in systolic blood pressure with no significant change in diastolic pressure (Prasath et al., 2021).…”

Section: Biological Activities and Presumed Health Benefits Of Fenugreekmentioning

confidence: 99%

Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications

Alu'datt,

Rababah,

Al‐ali

et al. 2024

Journal of Food Science

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Despite long‐standing uses in several food and medicine traditions, the full potential of the leguminous crop fenugreek (Trigonella foenum‐graecum L.) remains to be realized in the modern diet. Not only its seeds, which are highly prized for their culinary and medicinal properties, but also its leaves and stems abound in phytochemicals with high nutritional and health promoting attributes. Fenugreek dual food‐medicine applications and reported metabolic activities include hypoglycemic, antihyperlipidemic, antioxidative, anti‐inflammatory, antiatherogenic, antihypertensive, anticarcinogenic, immunomodulatory, and antinociceptive effects, with potential organ‐protective effects at the cardiovascular, digestive, hepatic, endocrine, and central nervous system levels. Effectiveness in alleviating certain inflammatory skin conditions and dysfunctions of the reproductive system was also suggested. As a food ingredient, fenugreek can enhance the sensory, nutritional, and nutraceutical qualities of a wide variety of foods. Its high nutritive density can assist with the design of dietary items that meet the demand for novelty, variety, and healthier foods. Its seeds provide essential protective nutrients and other bioactive compounds, notably galactomannans, flavonoids, coumarins, saponins, alkaloids, and essential oils, whose health benefits, alone or in conjunction with other bioactives, are only beginning to be tapped into in the food industries. This review summarizes the current state of evidence on fenugreek potential for functional food development, focusing on the nutrients and non‐nutrient bioactive components of interest from a dietary perspective, and their applications for enhancing the functional and nutraceutical value of foods and beverages. New developments, safety, clinical evidence, presumed mechanisms of action, and future perspectives are discussed.Highlights Fenugreek seeds and leaves have long‐standing uses in the food‐medicine continuum. Fenugreek phytochemicals exert broad‐spectrum biological and pharmacological activities. They show high preventive and nutraceutical potential against common chronic diseases. Current evidence supports multiple mechanisms of action mediated by distinct bioactives. Opportunities for fenugreek‐based functional foods and nutraceuticals are expanding.

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“…Fenugreek Seed (FS) exhibits a significant antihypertensive effect. Supplementation with FS, especially in dosages ≥ 15 g/day and durations ≤ 12 weeks, might play a role in reducing SBP, but not DBP [71]. Consumption of FS through oral administration pre-prandially causes a significant decrease in SBP.…”

Section: Fenugreekmentioning

confidence: 99%

A Review on Efficacy of Dietary Approaches in The Management of Hypertension

2023

IJFMR

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Hypertension (HTN), commonly known as the 'Silent Killer,' presents a significant worldwide health concern, with a prevalence of 24% in men and 21% among women in India. As lifestyle and food culture evolve, the prevalence of Non-Communicable Diseases (NCD) is increasing, thereby impacting overall health. The primary objective of this study is to conduct a comprehensive review of existing literature with a view towards exploring the recent advancements in diet and nutritional approaches for individuals with HTN. This study aims to understand the importance of different diets such as the DASH diet, Mediterranean diet, potassium-rich diet, low salt diet and vegetarian diet which have been recommended globally owing to their varying ability to lower Blood Pressure (BP). Additionally, it emphasises the significance of protein in reducing BP, especially in India, where protein deficiency is highly prevalent. The study also investigates the role of simple and easily accessible functional foods that exhibit antihypertensive effects, with supporting evidence for their efficacy. The study's findings indicate that adopting a consistent diet regime, such as a balanced diet with sufficient high-quality protein (at least 0.83g/kg/day), along with generous portions of fruits, vegetables and reduced salt intake, has proven to be highly effective in managing BP. Complementing non-pharmacological interventions with lifestyle modifications, such as healthy eating, regular physical activity, weight management, abstaining from smoking, limiting alcohol consumption and implementing stress management techniques, can collectively contribute to preventing and controlling HTN, thus reducing the disease burden. An effective change in the daily diet consistent with current protein recommendations is helpful in BP control.

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The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Cited by 8 publications

References 52 publications

A Scoping Review of the Clinical Evidence for the Health Benefits of Culinary Doses of Herbs and Spices for the Prevention and Treatment of Metabolic Syndrome

A Scoping Review of the Clinical Evidence for the Health Benefits of Culinary Doses of Herbs and Spices for the Prevention and Treatment of Metabolic Syndrome

Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications

A Review on Efficacy of Dietary Approaches in The Management of Hypertension

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