The Effects of folic acid and topiramate on peripheral nerve regeneration

Sağir, Dilek; Kuruoğlu, Enis; Önger, Mehmet Emin; Yarar, Ercan

doi:10.1080/10520295.2019.1637022

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…T A B L E 1 Scoring of the expression of anti-S100 and anti-Ki-67 belonging to the groups in Schwann cells and areas of epineurium, perineurium, and endoneurium. The study of nerve repair and regeneration has a long history and is undoubtedly the most addressed problem in the study of the peripheral nervous system (Delibas et al, 2021;Herrera-Rincon et al, 2022;Sagir et al, 2020). Experimental research on mechanical nerve compression has been conducted to examine the changes in the proximal and distal anatomical structures of the lesion in the sciatic nerve (Challa, 2015).…”

Section: Flow Cytometric Analysis Resultsmentioning

confidence: 99%

Pigment epithelium‐derived factor enhances peripheral nerve regeneration through modulating oxidative stress and stem cells

Önger

Altun

Yıldıran

2023

The Anatomical Record

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Peripheral nerve injury is common and negatively affects an individual's quality of life. Drugs used for peripheral nerve regeneration should aim to eliminate symptoms such as neuropathic pain and have therapeutic effects. In recent studies, pigment epithelium‐derived factor (PEDF) has been considered an essential therapeutic agent because of its potential neuroprotective properties. In this study, we aimed to investigate the efficacy of locally applied PEDF for peripheral nerve regeneration. Twenty‐four Wistar albino male rats were used. The study groups included Injury (n = 12) and Injury+PEDF (n = 12). An injury model was created by applying 50 N pressure to the right sciatic nerves in groups, and 10 μg/kg local PEDF was injected into the Injury+PEDF group. After 28 days of recovery, functional tests and stereological, immunohistochemical, and biochemical analyses were performed. A significant difference was found between the Injury and Injury+PEDF groups in amplitude, whereas no difference was found in latency. The number of myelinated axons and the myelinated axon area increased significantly in the Injury+PEDF group, while no statistically significant difference was found in myelin sheath thickness. Superoxide dismutase, catalase, and glutathione peroxidase activities were increased by PEDF, whereas they were suppressed in mesenchymal stem cells. PEDF exerts functional, quantitative, and antioxidative effects on sciatic nerve injury during neuroregeneration. In addition, when oxidative stress parameters were examined, it was seen that PEDF reduced oxidative stress following sciatic nerve injury.

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Section: Flow Cytometric Analysis Resultsmentioning

confidence: 99%

Pigment epithelium‐derived factor enhances peripheral nerve regeneration through modulating oxidative stress and stem cells

Önger

Altun

Yıldıran

2023

The Anatomical Record

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“…Vitamin B9 (Folic acid) improves peripheral nerve regeneration, as demonstrated by Hamra et al and Sagır et al Both studies showed improved electromyographic results and preserved axons with increased quantity and density and increased myelination after intraperitoneal injection of folic acid [131,134]. From an in vitro study by Kang et al, the improved regeneration may be attributable mainly to improved SC migration and proliferation as well as an increased secretion of NGF [132].…”

Section: Water-soluble Vitamins Vitamin Bmentioning

confidence: 95%

The Role of Dietary Nutrients in Peripheral Nerve Regeneration

Soury

Fornasari

Carta

et al. 2021

IJMS

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Peripheral nerves are highly susceptible to injuries induced from everyday activities such as falling or work and sport accidents as well as more severe incidents such as car and motorcycle accidents. Many efforts have been made to improve nerve regeneration, but a satisfactory outcome is still unachieved, highlighting the need for easy to apply supportive strategies for stimulating nerve growth and functional recovery. Recent focus has been made on the effect of the consumed diet and its relation to healthy and well-functioning body systems. Normally, a balanced, healthy daily diet should provide our body with all the needed nutritional elements for maintaining correct function. The health of the central and peripheral nervous system is largely dependent on balanced nutrients supply. While already addressed in many reviews with different focus, we comprehensively review here the possible role of different nutrients in maintaining a healthy peripheral nervous system and their possible role in supporting the process of peripheral nerve regeneration. In fact, many dietary supplements have already demonstrated an important role in peripheral nerve development and regeneration; thus, a tailored dietary plan supplied to a patient following nerve injury could play a non-negotiable role in accelerating and promoting the process of nerve regeneration.

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Factores de riesgos y trastornos por deficiencia de folato en embarazadas

Zambrano Garcés,

Montaño Pérez,

Lema Puin

et al. 2024

ConcienciaDigital

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Introducción: La deficiencia de folato es un problema de salud que puede tener consecuencias significativas, especialmente durante el embarazo. El ácido fólico, una forma sintética de folato, es crucial para el desarrollo celular y la formación del sistema nervioso del feto. La escasez de esta vitamina B en mujeres embarazadas es una preocupación importante en la salud materno-infantil, ya que se ha asociado con complicaciones graves. Objetivo: Determinar los factores de riesgos y trastornos por la deficiencia de folato en embarazadas. Metodología: El desarrollo de este estudio se basa en un tipo de investigación descriptiva que permite analizar las variables detalladas en el tema o idea principal. La investigación realizada tiene un enfoque cualitativo que se basa en el análisis de los factores de riesgo del déficit de folato en las embarazadas. El estudio descriptivo se basa en el análisis de las variables establecidas y analizar la correlación entre ambas. Resultados: La importancia crítica del folato durante el embarazo y las consecuencias perjudiciales que surgen a raíz de su deficiencia. La relación entre la falta de folato y los defectos del tubo neural es un punto central, ya que esta vitamina es esencial para la correcta formación del tubo neural en el feto. Conclusión: Se identificaron factores cruciales que inciden en la deficiencia de folato durante el embarazo, tales como la inadecuada ingesta de alimentos ricos en folato, padecimientos clínicos como la patología celíaca o enfermedades intestinales, el consumo excesivo de alcohol, y antecedentes de embarazos con defectos del tubo neural. Área de estudio general: Medicina. Área de estudio específica: Enfermería.

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The Effects of folic acid and topiramate on peripheral nerve regeneration

Cited by 3 publications

References 32 publications

Pigment epithelium‐derived factor enhances peripheral nerve regeneration through modulating oxidative stress and stem cells

Pigment epithelium‐derived factor enhances peripheral nerve regeneration through modulating oxidative stress and stem cells

The Role of Dietary Nutrients in Peripheral Nerve Regeneration

Factores de riesgos y trastornos por deficiencia de folato en embarazadas

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