The effects of garlic (<i>Allium sativum</i>) supplementation on inflammatory biomarkers, fatigue, and clinical symptoms in patients with active rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled trial

Moosavian, Seyedeh Parisa; Paknahad, Zamzam; Habibagahi, Zahra; Maracy, Mohammadreza

doi:10.1002/ptr.6723

Cited by 32 publications

(31 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One double-blind randomized controlled trial by Moosavian et al with a low risk of bias assessed the effect of a garlic supplementation (1000 mg garlic powder tablets equivalent to 2.5 g of fresh garlic, i.e., half of a garlic clove) on RA activity in 70 patients (35 per group) [ 11 , 12 ]. There was no significant difference between the two groups for DMARDS and corticosteroids.…”

Section: Resultsmentioning

confidence: 99%

“…Tolerance was good in the six studies: stomach pain in one patient with garlic and saffron supplementation [ 11 , 12 , 18 ] and mild fever and throat infection in one patient with curcumin supplementation [ 13 ]. Clinical trials assessing saffron, curcumin, and garlic supplementation showed similar mild adverse events between control and experimental groups [ 20 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is unreasonable to expect these supplements to surpass the effect of DMARD therapy and, at most, they should be considered as an experimental adjunct. In the four other studies [ 11 , 12 , 15 , 16 , 17 , 18 ], patients with active RA did not receive bDMARDs, which is not the standard care for RA in Western countries [ 33 , 34 ]. Moreover, the six studies were done in only two countries: India and Iran.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review

Letarouilly

Sanchez²,

Nguyen

et al. 2020

Nutrients

View full text Add to dashboard Cite

Background: Spices, i.e., curcumin, ginger, saffron, and cinnamon, have a thousand-year history of medicinal use in Asia. Modern medicine has begun to explore their therapeutic properties during the last few decades. We aimed to perform a systematic literature review (SLR) of randomized controlled trials (RCTs) assessing the effect of spice supplementation on symptoms and disease activity in patients with chronic inflammatory rheumatic diseases (rheumatoid arthritis (RA), spondylarthritis, or psoriatic arthritis). Methods: An SLR of RCTs, reviews, and meta-analyses was performed, searching for articles in MEDLINE/PubMed. Abstracts from international rheumatology and nutrition congresses (2017–2020) were also scrutinized. The risk of bias of the selected studies was evaluated using the Cochrane Collaboration’s tool and the Jadad scale. Results: Altogether, six studies, assessing the use of spice supplementation only in RA patients, were included: one on garlic supplementation, two on curcumin, one on ginger, one on cinnamon, and one on saffron supplementation. Garlic, ginger, cinnamon, or saffron supplementation was associated with a decrease in RA clinical activity. However, several points limit the external validity of these studies. No conclusion on the impact of curcumin supplementation on RA activity could be drawn due to low-quality studies. Conclusions: Garlic, ginger, cinnamon, and saffron supplementation could have a beneficial effect on RA activity, but the risk of bias of these studies is difficult to assess and data are too limited to recommend them in daily practice.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review

Letarouilly

Sanchez²,

Nguyen

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…Harmful agents activate inflammatory cells, such as neutrophils and macrophages, and induce the release of proinflammatory molecules, including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). Although inflammation is an essential component for a proper immune response and the maintenance of homeostasis in the body [ 2 , 3 ], chronic inflammation plays a key role in the onset and progression of several chronic diseases, including diabetes [ 4 ], cardiovascular diseases [ 5 ], neurodegenerative diseases [ 6 ], rheumatoid arthritis [ 7 ], and cancer [ 8 ]. Popular approaches suggest controlling inflammation through pharmacological [ 9 , 10 , 11 ] and dietary interventions [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials

et al. 2021

Self Cite

View full text Add to dashboard Cite

It has been theorized that folic acid supplementation improves inflammation. However, its proven effects on inflammatory markers are unclear as clinical studies on this topic have produced inconsistent results. To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Methods: To identify eligible RCTs, a systematic search up to April 2021 was completed in PubMed/Medline, Scopus, Web of Science, EMBASE, Cochrane databases, and Google Scholar using relevant keywords. A fix or random-effects model was utilized to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI). Results: Twelve RCTs were included in the present meta-analysis. The pooled analysis revealed that serum concentrations of CRP (WMD: −0.59 mg/L, 95% CI −0.85 to −0.33, p < 0.001) were significantly reduced following folic acid supplementation compared to placebo, but did not affect serum concentrations of IL-6 (WMD: −0.12, 95% CI −0.95 to 0.72 pg/mL, p = 0.780) or TNF-α (WMD: −0.18, 95% CI −0.86 to 0.49 pg/mL, p = 0.594). The dose–response analysis demonstrated a significant relationship between an elevated dosage of folic acid supplementation and lower CRP concentrations (p = 0.002). Conclusions: We found that folic acid supplementation may improve inflammation by attenuating serum concentrations of CRP but without significant effects on IL-6 and TNF-α. Future RCTs including a larger number of participants and more diverse populations are needed to confirm and expand our findings.

show abstract

“…Also, organosulfur compounds in garlic ( Allium sativum L ) such as allicin and s‐allylcysteine are thought to be the main bioactive compounds responsible for the management of blood pressure, inflammation, and hepatic steatosis (Soleimani et al, 2020). These compounds improve blood pressure and inflammation by inhibiting the angiotensin‐converting enzyme, and transcription factor NF‐κB (Moosavian et al., 2020; Xiong et al., 2015b). At present, based on our knowledge, no clinical evidence exists regarding the effect of garlic consumption on blood pressure, and hs‐CRP level among patients with NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Effect of garlic powder supplementation on blood pressure and hs‐C‐reactive protein among nonalcoholic fatty liver disease patients: A randomized, double‐blind, placebo‐controlled trial

Soleimani

Moosavian

Zolfaghari

et al. 2021

Food Science & Nutrition

Self Cite

View full text Add to dashboard Cite

Based on the anti‐inflammatory and antihypertensive properties of garlic, the current study was designed to evaluate the garlic powder effects on blood pressure and high‐sensitivity C‐reactive protein (hs‐CRP) among Nonalcoholic Fatty Liver Disease patients (NAFLD). This randomized, double‐blind, placebo‐controlled trial study was conducted on 110 patients with NAFLD. The patients were randomly divided into 2 groups, receiving two tablets of either 400 mg garlic or placebo daily for 15 weeks. At baseline and the end of the study, blood pressure and hs‐CRP were determined. Of 110 patients enrolled in the trial, 98 subjects were included in the final analysis. After the intervention, systolic blood pressures (SBP) (mean: −7.89; 95%CI:‒11.39 to −4.39 mm Hg), diastolic blood pressure (DBP) (mean: −5.38; 95%CI: −7.77 to −3 mm Hg), and Mean Arterial Pressure (MAP) (mean: −6:95%CI: −8.4 to −3.6 mm Hg) decreased significantly in the garlic group as compared to the placebo group. Also, the percentage of reduced hs‐CRP was significantly higher in the intervention group compared with the control group (mean: −16.1; 95%CI: −32.7 to −0.53; p = .035). Moreover, a positive correlation was observed between the percentage change in hs‐CRP and percentage changes in SBP (r = 0.221; p = .029), DBP (r = 0.166; p = .012), and MAP (r = 0.210; p = .038). Garlic supplementation can be a safe and potentially adjunct treatment to reduce blood pressure and the risk of cardiovascular disorders in patients with NAFLD.

show abstract

The effects of garlic (Allium sativum) supplementation on inflammatory biomarkers, fatigue, and clinical symptoms in patients with active rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled trial

Cited by 32 publications

References 46 publications

Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review

Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review

Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials

Effect of garlic powder supplementation on blood pressure and hs‐C‐reactive protein among nonalcoholic fatty liver disease patients: A randomized, double‐blind, placebo‐controlled trial

Contact Info

Product

Resources

About