The effects of genetic and seasonal factors on reproductive success

Gloria‐Bottini, F.; Bottini, Nunzio; Torre, M. La; Magrini, Andrea; Bergamaschi, Antonio; Bottini, E.

doi:10.1016/j.fertnstert.2007.04.030

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Women homozygous for Hp with low ACP1 activity are more likely to conceive in the first part of the year, while women heterozygous for Hp with medium-high ACP1 activity are more likely to conceive in the latter part of the year. This suggests that ACP1 may play a role in delivering offspring into an environment favourable for development (Gloria-Bottini et al, 2008). A concordant, highly significant association between ACP1 parameters and the season of conception can also be observed in newborn infants.…”

Section: Discussionmentioning

confidence: 82%

The Impact of Maternal Birth Month on Reproductive Performance: Controlling for Socio-Demographic Confounders

Kemkes¹

2009

J. Biosoc. Sci.

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Based on a 1900 census sample of 34,166 post-reproductive females (> or =45 years), the birth month effect was put to the test, for both lifetime fertility as well as child survival, controlling for maternal birth cohort (1826-1835, 1836-1845, 1846-1855), Duncan's SEI, urbanity, nativity, literacy and marital duration. Testing for potential cohort effects did not indicate a temporal trend in fertility by maternal birth month (seasonal Mann-Kendall test, p=0.578), while a minute increase in offspring survival was detected (p<0.001, Sen's estimator of slope=0.02, 95% CI=0.02 to 0.03). Further analyses of the maternal birth month effect on child survival were therefore seized. For lifetime fertility, ANOVA results indicated that maternal birth month was a major predictor for total offspring count (F11, 33606=1809.0, p<0.001), accounting for 37.2% of the total variability. In addition to main effects, a statistically significant interaction effect was observed (F538, 33606=2.2, p<0.001), with a corresponding effect size of eta2=0.40. Planned contrasts revealed that birth-month-specific differences in fertility achieved statistical significance (F11, 31798=1712.9, p<0.001), while post-hoc multiple comparisons for literacy and nativity displayed an inverse relationship with fertility, which meets demographic expectations. Controlling for all factors of interest, models of cohort-specific offspring counts (independent ANOVAs for 1826-1835: F157, 3467=26.3, p<0.001; 1836-1845: F182, 10299=75.5, p<0.001; 1846-1855: F199, 19859=137.9, p<0.001) indicated that women born in the first half of the year (particularly, January, February, April and May) achieved above-average parity, while those born in the latter half (namely, July, October, November and December) displayed markedly lower fertility averages. These monthly disparities are in line with previous observations and appear to be linked to seasonal optimal ripening of the oocyte or seasonal preovulatory over-ripeness ovopathy (Jongbloet, 1992).

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Section: Discussionmentioning

confidence: 82%

The Impact of Maternal Birth Month on Reproductive Performance: Controlling for Socio-Demographic Confounders

Kemkes¹

2009

J. Biosoc. Sci.

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“…But the presence of Hp allele 1 seems to be a protective factor for these outcomes, as it was observed by the other authors [31–33]. For some authors, this can be due to the great immune tolerance potential of the Hp 2.1 phenotype [34, 35]. However, this subject is controversial [36, 37].…”

Section: Discussionmentioning

confidence: 89%

In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism

Matos

Silva

Bicho

et al. 2014

Obstetrics and Gynecology International

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Preeclampsia (PE) may affect the risk for future cardiovascular disease. Haptoglobin (Hp), an acute phase protein with functional genetic polymorphism, synthesized in the hepatocyte and in many peripheral tissues secondary of oxidative stress of PE, may modulate that risk through the antioxidant, angiogenic, and anti-inflammatory differential effects of their genotypes. We performed a prospective study in 352 women aged 35 ± 5.48 years, which 165 had previous PE, 2 to 16 years ago. We studied demographic, anthropometric, and haemodynamic biomarkers such as C-reactive protein (CRP), myeloperoxidase (MPO), and nitric oxide metabolites (total and nitrites), and others associated with liver function (AST and ALT) and lipid profile (total LDL and cholesterol HDL, non-HDL, and apolipoproteins A and B). Finally, we study the influence of Hp genetic polymorphism on all these biomarkers and as a predisposing factor for PE and its remote cardiovascular disease prognosis. Previously preeclamptic women either hypertensive or normotensive presented significant differences in those risk biomarkers (MPO, nitrites, and ALT), whose variation may be modulated by Hp 1/2 functional genetic polymorphism. The history of PE may be relevant, in association with these biomarkers to the cardiovascular risk in premenopausal women.

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“…Alguns estudos mostraram influência do tabagismo ativo dos pais em aumentar a proporção de nascimentos do sexo feminino (100)(101)(102) . Em relação às estações do ano, um estudo constatou uma influência nas taxas de sucesso de concepção (103) , mas quanto à influência na razão sexual dos nascimentos, os resultados são conflitantes (104)(105)(106)(107) . Além disso, esses estudos foram realizados em países do hemisfério norte, onde as estações são bem definidas, sendo o contrário do que ocorre na cidade de São Paulo, em que não há estações bem definidas (3) .…”

Section: Influência Da Poluição Na Determinação Do Sexo Do Rnunclassified

Associação entre exposição materna à poluição na cidade de São Paulo e desfechos da gestação

Carvalho¹

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The effects of genetic and seasonal factors on reproductive success

Cited by 6 publications

References 31 publications

The Impact of Maternal Birth Month on Reproductive Performance: Controlling for Socio-Demographic Confounders

The Impact of Maternal Birth Month on Reproductive Performance: Controlling for Socio-Demographic Confounders

In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism

Associação entre exposição materna à poluição na cidade de São Paulo e desfechos da gestação

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