Mixed convection heat transfer and fluid flow through an open-cell aluminium foam around various heat source shapes with constant heat flux inside rectangular horizontal channel, filled with nanofluid is numerically investigated. An open-cell aluminium foam is made of alloy 6101-T6 with porosity 93% and pore densities (10 40) PPI. Nanofluid with three different types of nanoparticles, aluminium oxide (Al 2 O 3 ), copper oxide (CuO) and silicon dioxide (SiO 2 ) with volume fraction of 4% and nanoparticle diameter of (25 nm) dispersed in water are used. Four models of cylindrical shapes are employed as test sections: (model 1) aluminium foam is around a rectangular cylinder = 90 , (model 2) the aluminium foam is around a trapezoidal cylinder shape ( = 82 875 , (model 3) aluminium foam is around a trapezoidal cylinder shape = 75 964 and (model 4) the aluminium foam is around the triangular cylinder shape = 63 435 .In all models, the heat flux is 300 W/m 2 and, aluminium foam length of (5 cm) is used with Reynolds number range of (200-600). The governing equations continuity, momentum and energy are solved by using the Finite-volume method (FVM). The effects of aluminium foam, nanofluid properties and Reynolds number on the Nusselt number and friction factor values, with four models in a rectangular horizontal channel are investigated. The results have shown that higher average Nusselt number is obtained with the use of nanofluid (water + SiO 2 and 40PPI aluminium foam pore density at higher Reynolds number with model (4). Low friction factor is obtained with the use of nanofluid (water + SiO 2 and 10PPI aluminium foam pore density at higher Reynolds number with model (4). Average Nusselt number increases and friction factor decreases when Reynolds number value increases with all models.