The effects of gingko biloba extract (EGb 761) on experimental acute pancreatitis

Zeybek, Nazif; Gorgulu, Semih; Yağcı, Gökhan; Serdar, Muhittin; Şimşek, Abdurrahman; Kaymakçıoğlu, Nihat; Deveci, Salih; Özçelik, Hakan; Tufan, Turgut

doi:10.1016/s0022-4804(03)00190-2

Cited by 36 publications

(23 citation statements)

References 18 publications

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“…Two randomized, double-blind, placebo-controlled trials (Schneider et al, 2005;Horsch and Walther, 2004) proved that EGb could improve cognitive performance of patients with Alzheimer's disease and the outcome of patients with peripheral arterial occlusive disease. Zeybek et al(2003) found prophylactic application of EGb caused significant decrease in serum amylase and lipase levels compared with the control group. Yamaguchi et al(1999) treated rats with EGb after inducing SAP by caerulin.…”

Section: Ginkolide Bmentioning

confidence: 82%

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Zhang

Liu

Shi

2007

J. Zhejiang Univ. - Sci. B

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Abstract:Severe acute pancreatitis (SAP) is a common acute abdomen clinical problem characterized by high mortality, multiple complications, complicated pathogenesis and difficult treatment. Recent studies found traditional Chinese medicine (TCM) monomers have markedly good effect for treating SAP. Many TCM monomers can inhibit pancreatin, resist inflammation, improve microcirculation and immunoloregulation, etc. to block the pathological progress of SAP in multiple ways, reduce complications and lower mortality with rapid effects. It is significant for enhancing SAP treatment to deeply understand the current situation in TCM monomers for treating SAP and take precious references therein. This article summarizes the treating effects and mechanisms of TCM monomers for SAP in recent years.

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Section: Ginkolide Bmentioning

confidence: 82%

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Zhang

Liu

Shi

2007

J. Zhejiang Univ. - Sci. B

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“…Zeybek et al reported that G. biloba significantly decreased MDA levels and histopathological scores of the pancreatitis in rats. 49 Bridi et al reported that G. biloba had antioxidant activity in the hippocampus, striatum, and substantia nigra of rats. 50 EGb 761 has an antioxidant effect as a free radical scavenger, a relaxing effect on vascular walls, an ameliorating effect on blood flow and microcirculation, and a stimulating effect on neurotransmitters.…”

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confidence: 99%

Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident ( Ischaemic Stroke ) : The Role of Ginkgo Biloba Extract

Thanoon¹,

Abdul-Jabbar²,

Taha³

2012

SQUMJ

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abstract:Objectives: This study aimed to investigate the presence of oxidative stress and inflammation in ischaemic stroke patients by measuring malondialdehyde (MDA), total antioxidant status (TAS), and highlysensitivity C-reactive protein (hsCRP) in the early post-ischaemic period, and to determine the role of Ginkgo biloba therapy in correcting the markers of oxidative stress and inflammation. Methods: This study was conducted at Ibn Seena Hospital, Mosul City, Iraq and included 31 cerebrovascular accident (CVA) patients and 30 healthy controls. Ischaemic stroke patients were divided into two groups: group I (n = 15) received conventional therapy; group II (n = 16) received conventional therapy with G. biloba (1500 mg/day) for 30 days. Blood samples were obtained from patients and controls before treatment and assays done of serum levels of MDA, TAS, and hsCRP. For CVA patients, a post-treatment blood sample was taken and the same parameters reassessed. Results: Compared with the controls, patients' serum levels of MDA, and hsCRP were significantly higher (P ≤0.001) and TAS significantly lower. Group I and II patients reported a significant reduction in serum levels of MDA and hsCRP and a significant increase in serum levels of TAS, in comparison with pre-treatment levels. There was no significant difference (P = 0.19) in serum MDA levels between groups I and II, whereas, serum TAS levels were significantly higher (P ≤0.01) and hsCRP significantly lower (P ≤0.01) in group II. Conclusion: Acute stroke is associated with oxidative stress and inflammatory response in the early period. G. biloba plays a potential role in reducing oxidative damage and

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“…An animal study showed that prophylactic treatment with this extract resulted in a decrease in serum amylase and lipase levels as well as better histopathologic appearance of the pancreas. 74 There was minimal parenchymal inflammation and edema on pancreatic histopathology samples. The authors concluded that attenuation of inflammation was secondary to the antioxidant effect of EGb 761.…”

Section: Antioxidants and Herbal Supplementsmentioning

confidence: 93%

Nutritional advice for prevention of acute pancreatitis: review of current opinion

Lowe¹,

Sevilla²

2012

NDS

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Pancreatitis is inflammation of the pancreas that can be acute and self-limiting or, in a small percentage of patients, recurrent. Patients with recurrent episodes of acute pancreatitis (RAP) often progress to chronic pancreatitis. Pancreatitis in all forms causes significant economic and social burdens. Prevention of RAP may decrease those burdens and halt progression to chronic disease. Unfortunately, no therapy has proven effective at altering the course of RAP. While enteral nutritional therapy plays an important role in the treatment of acute pancreatitis during episodes, nutritional advice provided to patients in an attempt to prevent recurrent episodes has not proven effective in most cases. Discontinuing alcohol consumption and treating dyslipidemia with diet and medication can help patients with these issues. In patients whose pancreatitis is associated with celiac disease or eosinophilic gastroenteritis, a gluten-free diet and avoidance of food allergens can be effective in stopping RAP. Advice to take pancreatic enzyme replacement therapy, lose weight, control diabetes, decrease dietary sucrose, decrease dietary fat or avoid monosodium glutamate has little to no evidence of efficacy. Some studies suggest that an antioxidant cocktail may decrease the frequency of RAP and the intensity of chronic pain, but the evidence is weak. Nutritional therapy may have a role in the treatment of patients with RAP. At present, there are no clear guidelines for nutritional advice to give these patients. More studies are needed to identify nutritional interventions that will benefit patients with RAP.

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The effects of gingko biloba extract (EGb 761) on experimental acute pancreatitis

Cited by 36 publications

References 18 publications

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Study progress in therapeutic effects of traditional Chinese medicine monomer in severe acute pancreatitis

Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident ( Ischaemic Stroke ) : The Role of Ginkgo Biloba Extract

Nutritional advice for prevention of acute pancreatitis: review of current opinion

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