The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor

Belviranlı, Muaz; Okudan, Nilsel

doi:10.1016/j.bbr.2014.10.032

Cited by 54 publications

(38 citation statements)

References 65 publications

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“…Many diseases are related to oxidative stress, such as hearing loss, where there is observed a critical increase of ROS in the cochlea blood flow; this same excess in the eyes may lead to cataracts. Oxidative stress leads to lipid peroxidation, protein oxidation, and DNA mutation, causing damage to nerve cells and being responsible for neurological disorders [23][24][25][26][27].…”

Section: Gb and Oxidative Stressmentioning

confidence: 99%

“…To investigate the effects of EGB761 on cognitive functions, Belviranli and Okudan [25] performed research on Wistar mice and found out that, with the supplementation of EGB761, there was significant improvement not only in the locomotor activity but also in anxiety, spatial learning, and memories. Another important discovery of this research was that in older rats, there was an improvement of the oxidative damage in cerebral tissue.…”

Section: Wistar Ratsmentioning

confidence: 99%

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Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

et al. 2020

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ABSTR AC TGinkgo biloba (GB) is one of the most widely used phytotherapeutic products in the world, and its extract has beneficial properties for the treatment of several pathologies, such as diabetic cardiomyopathy, neurodegenerative diseases, cataracts, hearing loss, myocardial lesion, hippocampus neuronal lesions, morphometry testicular changes, and liver damage. This review aims to investigate the effects of GB on diseases related to oxidative stress. Databases such as MEDLINE/ PUBMED and EMBASE were consulted, and PRISMA guidelines were used to build the review. This plant has antioxidant properties since it regulates the expression of antioxidant enzymes positively and reduces reactive oxygen and nitrogen species, contributing to the reduction of lipid peroxidation. It also exhibits anti-inflammatory properties, inhibiting the expression of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF-α. In animal models, the use of GB can show positive effects on brain damage, neurodegenerative diseases, myocardial injury, and renal and liver damage. In humans, the positive effects were shown in diabetes, metabolic syndrome, and ischemic colitis. These effects are due to the presence of compounds such as bilobalide, isoramnetina, quercetin, kaempferol, and ginkgolides A, B, and C. For these reasons, GB can be a lowcost alternative to the therapeutic approach of several pathologies since it acts in the prevention, treatment, and inhibition of several complications of common comorbidities.

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Section: Gb and Oxidative Stressmentioning

confidence: 99%

Section: Wistar Ratsmentioning

confidence: 99%

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

et al. 2020

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“…In aged female rats, GBE treatment inhibited the expression of MDA and 8-oxo-2′-deoxyguaniosine, improved the expression of brainderived neurotrophic factor in plasma, decreased oxidative damage, and improved cognitive functions. 27 In myocardial ischemia-reperfusion injury rabbits, GBE reduced the generation of oxygen free radicals and increased the antioxidant capacity of the myocardial cells. 28 In the present study, we found that GBE treatment improved SOD and GSH-PX activity, inhibited MDA expression, and decreased oxidative damage in A53T α-synuclein transgenic mice.…”

Section: Gbe Recovered the Expression Of Th And Dat In The A53t α-Synmentioning

confidence: 99%

Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson’s Disease

Shao-song

Yang

Rao

et al. 2017

Can. J. Neurol. Sci.

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“…EGb 761 decreased the levels of liver malondialdehyde and metalloproteinase and increased the activity of SOD to prevent the impairment of oxidative stress on aging liver fibrosis [ 24 ]. In aged female rats, levels of malondialdehyde and 8-hydroxy-2’-deoxyguanosine (8-OHdG) were found to be decreased with EGb treatment to result in an improvement in cognitive functions [ 25 ]. EGb could also decrease malondialdehyde in the rat testes, which is a well-known lipid peroxidation product [ 21 ].Other studies [ 18 , 26 ] have reported similar results to the above in various mouse tissues.…”

Section: Pharmacological Actions Of Egbmentioning

confidence: 99%

Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases

Zuo¹,

Yan²,

Zhang³

et al. 2017

Aging and disease

103

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The prevalence of degenerative disorders in public health has promoted in-depth investigations of the underlying pathogenesis and the development of new treatment drugs. Ginkgo biloba leaves extract (EGb) is obtained from Ginkgo biloba leaves and has been used for thousands of years. In recent decades, both basic and clinical studies have established the effects of EGb. It is widely used in various degenerative diseases such as cerebrovascular disease, Alzheimer’s disease, macroangiopathy and more. Here, we reviewed several pharmacological mechanisms of EGb, including its antioxidant properties, prevention of mitochondrial dysfunctions, and effect on apoptosis. We also described some clinical applications of EGb, such as its effect on neuro and cardiovascular protection, and anticancer properties. The above biological functions of EGb are mainly focused on aging-related disorders, but its effect on other diseases remains unclear. Thus, through this review, we aim to encourage further studies on EGb and discover more potential applications

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The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor

Cited by 54 publications

References 65 publications

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson’s Disease

Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases

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