The effects of gonadectomy and binge-like ethanol exposure during adolescence on open field behaviour in adult male rats

Yan, Wensheng; Kang, Jie; Zhang, Guoliang; Li, Shuangcheng; Kang, Yunxiao; Wang, Lei; Shi, Geming

doi:10.1016/j.neulet.2015.07.039

Cited by 9 publications

(2 citation statements)

References 31 publications

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“…Experiments using the light/dark box have shown that adolescent ethanol exposure increases time spent in the dark portion of the apparatus and decreases entries into the light side in male Sprague-Dawley rats (Pandey et al, 2015;Vetreno et al, 2016;Sakharkar et al, 2019). Anxiety-like behavior in the open-field (Coleman et al, 2014;Yan et al, 2015) and marble-burying test (Lee et al, 2017) have also been enhanced following adolescent ethanol exposure of Sprague-Dawley males (Yan et al, 2015) and male C57BL/6J mice (Coleman et al, 2014;Lee et al, 2017). When tested in adulthood, male Sprague-Dawley rats exposed to ethanol during early-mid adolescence demonstrated social anxiety-like behavioral alterations indexed via decreases in social investigation and social preference (Varlinskaya et al, 2014), with no changes in social behavior evident following late adolescent ethanol exposure.…”

Section: Adolescent Alcohol Exposure: Anxiety-like Behavioral Alteratmentioning

confidence: 99%

Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity

Towner

2020

Front. Behav. Neurosci.

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Adolescence is a developmental period associated with rapid age-specific physiological, neural, and hormonal changes. Behaviorally, human adolescents are characterized by age-typical increases in novelty-seeking and risk-taking, including the frequent initiation of alcohol and drug use. Alcohol use typically begins during early adolescence, and older adolescents often report high levels of alcohol consumption, commonly referred to as high-intensity drinking. Early-onset and heavy drinking during adolescence are associated with an increased risk of developing alcohol use disorders later in life. Yet, long-term behavioral consequences of adolescent alcohol use that might contribute to excessive drinking in adulthood are still not well understood. Recent animal research, however, using different exposure regimens and routes of ethanol administration, has made substantial progress in identifying the consequences of adolescent ethanol exposure that last into adulthood. Alterations associated with adolescent ethanol exposure include increases in anxiety-like behavior, impulsivity, risk-taking, and ethanol intake, although the observed alterations differ as a function of exposure regimens and routes of ethanol administration. Rodent studies have also shown that adolescent ethanol exposure produces alterations in sensitivity to ethanol, with these alterations reminiscent of adolescent-typical ethanol responsiveness. The goal of this mini-review article is to summarize the current state of animal research, focusing on the long-term consequences related to adolescent ethanol exposure, with a special emphasis on the behavioral alterations and changes to ethanol sensitivity that can foster high levels of drinking in adulthood.

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Section: Adolescent Alcohol Exposure: Anxiety-like Behavioral Alteratmentioning

confidence: 99%

Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity

Towner

2020

Front. Behav. Neurosci.

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“…In the open field test, animals treated with anxiolytics display an enhanced tendency to explore the central location of the field (Prut and Belzung, 2003;Yan et al, 2015). So, it was expected that exogenous testosterone treatment would increase activity in the central area of the open field.…”

Section: The Effect Of Gonadectomy On Anxiety Behaviormentioning

confidence: 99%

Modulation of anxiety behavior in gonadectomized animals

Khakpay

Khakpai

2020

Acta Neurobiologiae Experimentalis

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Anxiety is a complex psychological state which happens after stressful life experiences. Many factors such as daily life events, neurotransmitter systems, and different brain areas could influence anxiety behavior in humans and animals. For example, opioids and androgens decrease anxiety behavior both in humans and animals. Furthermore, removing the testes (gonadectomy) causes higher levels of anxiety-like behaviors, in which the administration of testosterone and opioid antagonist can reverse some of these behaviors. We review the effects of morphine and androgens on the modulation of anxiety behavior in gonadectomized animals. We begin by highlighting the effects of opioid drugs and androgens on the modulation of anxiety behavior that have been implicated in anxiety behavior. We then discuss the functional consequences of gonadectomy on anxiety behavior. Finally, we consider how the opioids and androgens may contribute to adaptive responses associated with anxiety.

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Testosterone ameliorated the behavioural deficits of gonadectomised rats and counteracted free radicals in a dosage-dependent manner

Kang

Jiang

Yan

2023

Behavioural Brain Research

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The effects of gonadectomy and binge-like ethanol exposure during adolescence on open field behaviour in adult male rats

Cited by 9 publications

References 31 publications

Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity

Adolescent Ethanol Exposure: Anxiety-Like Behavioral Alterations, Ethanol Intake, and Sensitivity

Modulation of anxiety behavior in gonadectomized animals

Testosterone ameliorated the behavioural deficits of gonadectomised rats and counteracted free radicals in a dosage-dependent manner

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