1975
DOI: 10.1016/0006-8993(75)90404-7
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The effects of gonadectomy and gonadal steroids on the activity of hypothalamic peptidases inactivating luteinizing hormone-releasing hormone (LH-RH)

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Cited by 55 publications
(10 citation statements)
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“…The greater tissue-related losses of GnRH in the static system despite the longer transit time of GnRH through the dynamic system chambers suggests that it is tissue-fixed rather than that free enzymes are primarily responsible for such proteolysis. Thus, despite the existence of enzymatic degradation of GnRH in hypothalamic tissue (30)(31)(32) and in incubation media (6), under the conditions of these experiments proteolytic losses were quantitatively slight. Since GnRH peptidase activity may be a regulatory factor governing the available pool of releasable GnRH stores in median eminence (30), routine inhibition of GnRH peptidases may be undesirable especially if it is not required.…”
Section: Discussionmentioning
confidence: 96%
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“…The greater tissue-related losses of GnRH in the static system despite the longer transit time of GnRH through the dynamic system chambers suggests that it is tissue-fixed rather than that free enzymes are primarily responsible for such proteolysis. Thus, despite the existence of enzymatic degradation of GnRH in hypothalamic tissue (30)(31)(32) and in incubation media (6), under the conditions of these experiments proteolytic losses were quantitatively slight. Since GnRH peptidase activity may be a regulatory factor governing the available pool of releasable GnRH stores in median eminence (30), routine inhibition of GnRH peptidases may be undesirable especially if it is not required.…”
Section: Discussionmentioning
confidence: 96%
“…Thus, despite the existence of enzymatic degradation of GnRH in hypothalamic tissue (30)(31)(32) and in incubation media (6), under the conditions of these experiments proteolytic losses were quantitatively slight. Since GnRH peptidase activity may be a regulatory factor governing the available pool of releasable GnRH stores in median eminence (30), routine inhibition of GnRH peptidases may be undesirable especially if it is not required. Since the quantitative losses of GnRH were so small, and in order to avoid interference with a potential physiological factor governing G n R H release, the routine addition of enzyme inhibitors should be re-evaluated.…”
Section: Discussionmentioning
confidence: 96%
“…The concentration of LHRH within the ME is believed to be in a dynamic state which depends on the combined rates of neuronal bio synthesis, storage, degradation and release. Previous studies have demonstrated that removal of gonadal steroids results in an increase in the rate of LHRH biosynthesis [24,30,31] and a decrease in the activity of hypothalamic LHRH de grading enzymes [15,16]. Since either of these alterations would tend to increase the concentration of LHRH within the neuron, the decreased concentration of LHRH observed within the ME following ovariectomy is most likely the re sult of an increased rate of release which exceeds the rate of synthesis.…”
Section: Discussionmentioning
confidence: 97%
“…This would be especially true in the ovariectomized animals in which the rate of synthesis is increased [24,30,31] and the rate of degradation decreased [15,16]. The concentration of LHRH visualized in the ME of several of the intact and ovariectomized suckled animals did appear to exceed that of the diestrous controls.…”
Section: Discussionmentioning
confidence: 99%
“…To our knowledge, developing PEP activity has not been studied so far in females. The GnRH-degrading system is known to be under sex steroid control [43,44,45] and neonatal female rats treated with androgen show higher peptidase activity inactivating mGnRH than normal animals [46]. This control mechanism may be of physiological interest in male rats, in which the plasma testosterone level increases just before birth and during the first postnatal days [47].…”
Section: Discussionmentioning
confidence: 99%