The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer’s disease

Zhang, Qianlin; Du, Xiaoping; Xu, Yuping; Lei, Dang; Li, Xiang; Zhang, Jiewen

doi:10.3892/etm.2013.1006

Cited by 24 publications

(11 citation statements)

References 20 publications

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“… 27 In the APP/PS1 double transgenic mice, a widely used animal model of Alzheimer’s disease, 2-week oral administration of Lyc significantly improved their spatial memory in Morris water maze test. 28 This radioprotective effect of Lyc should be related to the previously suggested effects of Lyc or LBP, including anti-oxidation, anti-inflammation, preventing neuron loss, and promoting neuronal regeneration. 29 The anti-oxidative effect of Lyc or LBP should be due to their activities in scavenging reactive oxygen species (ROS) and inhibiting oxidases.…”

Section: Discussionmentioning

confidence: 81%

Neuroprotective Effects of Lycium barbarum Berry on Neurobehavioral Changes and Neuronal Loss in the Hippocampus of Mice Exposed to Acute Ionizing Radiation

Guo

et al. 2021

Dose-Response

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Background: Brain exposure to ionizing radiation during the radiotherapy of brain tumor or metastasis of peripheral cancer cells to the brain has resulted in cognitive dysfunction by reducing neurogenesis in hippocampus. The water extract of Lycium barbarum berry (Lyc), containing water-soluble Lycium barbarum polysaccharides and flavonoids, can protect the neuronal injury by reducing oxidative stress and suppressing neuroinflammation. Reseach Design: To demonstrate the long-term radioprotective effect of Lyc, we evaluated the neurobehavioral alterations and the numbers of NeuN, calbindin (CB), and parvalbumin (PV) immunopositive hippocampal neurons in BALB/c mice after acute 5.5 Gy radiation with/without oral administration of Lyc at the dosage of 10 g/kg daily for 4 weeks. Results: The results showed that Lyc could improve irradiation-induced animal weight loss, depressive behaviors, spatial memory impairment, and hippocampal neuron loss. Immunohistochemistry study demonstrated that the loss of NeuN-immunopositive neuron in the hilus of the dentate gyrus, CB-immunopositive neuron in CA1 strata radiatum, lacunosum moleculare and oriens, and PV-positive neuron in CA1 stratum pyramidum and stratum granulosum of the dentate gyrus after irradiation were significantly improved by Lyc treatment. Conclusion: The neuroprotective effect of Lyc on those hippocampal neurons may benefit the configuration of learning related neuronal networks and then improve radiation induced neurobehavioral changes such as cognitive impairment and depression. It suggests that Lycium barbarum berry may be an alternative food supplement to prevent radiation-induced neuron loss and neuropsychological disorders.

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Section: Discussionmentioning

confidence: 81%

Neuroprotective Effects of Lycium barbarum Berry on Neurobehavioral Changes and Neuronal Loss in the Hippocampus of Mice Exposed to Acute Ionizing Radiation

Guo

et al. 2021

Dose-Response

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“…It has been reported that LBP could significantly improve the dextromethorphaninduced depression in the rat model (Po et al, 2017). In the APP/PS1 double transgenic mice, a widely used animal model of Alzheimer's disease, 2-week oral administration of Lyc significantly improved their spatial memory in Morris water maze test (Zhang et al, 2013). This radioprotective effect of Lyc should be related to the previously suggested effects of Lyc or LBP, including anti-oxidation, anti-inflammation, preventing neuron loss and promoting neuronal regeneration (Xing et al, 2016).…”

Section: Lyc Improves Radiation-induced Behavioral Impairmentsmentioning

confidence: 99%

Neuroprotective Effects of Lycium Barbarum Berry on Neurobehavioral Changes and Neuronal Loss in the Hippocampus of Mice Exposed to Acute Ionizing Radiation

Guo¹,

Du²,

P³

et al. 2021

Preprint

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Background: Brain exposure to ionizing radiation during the radiotherapy of brain tumor or metastasis of peripheral cancer cells to the brain has resulted in cognitive dysfunction by reducing neurogenesis in hippocampus. Methods: To demonstrate the radioprotective effect of lycium barbarum berry extract (Lyc), we evaluated the neurobehavioral alterations and the numbers of NeuN, calbindin (CB) and parvalbumin (PV) immunopositive hippocampal neurons in BALB/c mice after acute 5.5 Gy radiation with/without oral administration of Lyc at the dosage of 10 g/kg daily for 4 weeks. Results: The results showed that Lyc could improve irradiation-induced animal weight loss, depressive behaviors, spatial memory impairment and hippocampal neuron loss. Immunohistochemistry study demonstrated that the loss of NeuN-immunopositive neuron in the hilus of the dentate gyrus, CB-immunopositive neuron in CA1 strata radiatum, lacunosum moleculare and oriens, and PV-positive neuron in CA1 stratum pyramidum and stratum granulosum of the dentate gyrus after irradiation were significantly improved by Lyc treatment. Conclusions: The neuroprotective effect of Lyc on those hippocampal neurons may benefit the configuration of learning related neuronal networks and then improve radiation induced neurobehavioral changes such as cognitive impairment and depression. It suggests that lycium barbarum berry may be used as a potential radio-neuro-protective food supplement to prevent ionizing radiation induced neuron loss and neuropsychological disorders.

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“…In addition, a variety of chemical interventions, including excitatory amino acids such as glutamate, N -methyl- d -aspartate (NMDA) and kainic acid; neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA); and ageing-promoting agents such as d -galactose, are also shown to induce neurodegenerative symptoms via oxidative and inflammatory stresses [ 83 , 99 , 100 ]. As oxidative stress plays a pivotal role in neurodegeneration, antioxidant strategies, including food-derived antioxidant polysaccharides, are shown to attenuate neuronal damage and improve cognitive and motor functions in a range of neurodegenerative models ( Table 2 ) [ 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142...…”

Section: Alleviation Of Neurodegeneration By Food-derived Antioxidmentioning

confidence: 99%

“…Using transgenic C. elegans models that overexpress Aβ proteins, the D. indusiata polysaccharide DiPS is shown to alleviate chemosensory behavior dysfunction, which is associated with reduction of ROS level and MDA content, increase of SOD activity and alleviation of mitochondrial dysfunction [ 58 ]. Antioxidant polysaccharides are also shown to modulate pathogenic protein aggregation, e.g., L. barbarum polysaccharides can reduce Aβ42 protein level in hippocampal tissue and improve the performance of learning and memory in APP/PS1 mice [ 109 ]. Intriguingly, L. barbarum polysaccharide is also shown to inhibit the apoptosis and reduce cleaved-tau protein level, the main component of neurofibrillary tangles in AD patients, in rat primary cortical cells exposed to homocysteine, a sulfur-containing amino acid associated with several NDD [ 128 ].…”

Section: Alleviation Of Neurodegeneration By Food-derived Antioxidmentioning

confidence: 99%

Food-Derived Antioxidant Polysaccharides and Their Pharmacological Potential in Neurodegenerative Diseases

Ding

Xiao

et al. 2017

Nutrients

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Oxidative stress is known to impair architecture and function of cells, which may lead to various chronic diseases, and therefore therapeutic and nutritional interventions to reduce oxidative damages represent a viable strategy in the amelioration of oxidative stress-related disorders, including neurodegenerative diseases. Over the past decade, a variety of natural polysaccharides from functional and medicinal foods have attracted great interest due to their antioxidant functions such as scavenging free radicals and reducing oxidative damages. Interestingly, these antioxidant polysaccharides are also found to attenuate neuronal damages and alleviate cognitive and motor decline in a range of neurodegenerative models. It has recently been established that the neuroprotective mechanisms of polysaccharides are related to oxidative stress-related pathways, including mitochondrial function, antioxidant defense system and pathogenic protein aggregation. Here, we first summarize the current status of antioxidant function of food-derived polysaccharides and then attempt to appraise their anti-neurodegeneration activities.

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The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer’s disease

Cited by 24 publications

References 20 publications

Neuroprotective Effects of Lycium barbarum Berry on Neurobehavioral Changes and Neuronal Loss in the Hippocampus of Mice Exposed to Acute Ionizing Radiation

Neuroprotective Effects of Lycium barbarum Berry on Neurobehavioral Changes and Neuronal Loss in the Hippocampus of Mice Exposed to Acute Ionizing Radiation

Neuroprotective Effects of Lycium Barbarum Berry on Neurobehavioral Changes and Neuronal Loss in the Hippocampus of Mice Exposed to Acute Ionizing Radiation

Food-Derived Antioxidant Polysaccharides and Their Pharmacological Potential in Neurodegenerative Diseases

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