The effects of grape seed extract against toxicity of benzene on liver and kidney tissues of albino mice: biochemical evaluation

Çavuşoğlu, Kültiğin; Yalçın, Emine; Yapar, Kürşad; Oruç, Ertan; Gür, Birgül; Çiçek, Figen

doi:10.5505/tjb.2015.22448

Cited by 4 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data demonstrated that BZ administration caused a significant increase in MDA levels as compared to control group in the kidney tissue, which reflects extensive lipid peroxidation process in the kidney of rats after BZ exposure. Our results are in good agreement with Çavuşoğlu et al who found that BZ administration at a dose 50 mg/kg of body weight for 50 days caused a significant increase in kidney MDA [38].…”

Section: Discussionsupporting

confidence: 93%

Protective Role of Aqueous Extract of Atriplex Halimus L. Against Benzene-Induced Damage on Renal Function and Glomerular Cells in Rats

Zeghib

Boutlelis²

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Benzene (BZ) is an important pollutant compound, present in both occupational and general environment that has been linked to adverse health effect. The aim of the current study was to investigate the curative and preventive effect of Atriplex halimus L. (Ah) extract against BZ-induced nephrotoxicity in rats. Methods: A total of 30 male albino Wistar rats were divided into five groups (n=6): Control, Ah, BZ, AhP+BZ, and BZ+AhC. BZ (100 mg/kg b.w) was added in their drinking water for 15 weeks. Ah (Aqueous Extract of aerial parts) was given by gavage during the past 30 days of BZ-exposed for curative treatment (AhC) and all the duration of BZ exposure in the animals for preventive treatment (AhP). Some biochemical, oxidative stress parameters, and histopathology of kidney tissue were studied. Results: Obtained results revealed that BZ exposure to rats caused a significant elevation in urea, creatinine, and malondialdehyde levels. Then, it led to reducing the glutathione level, catalase, and glutathione-S-transferase activities when compared to the control animals. Histopathological studies showed a massive damage in kidneys of the BZ-exposed rat. Our results showed that curative treatment of aqueous extract of Ah has a partial correction of the biochemical, oxidative stress parameters, and kidney morphology, but preventive treatment has a dramatic effect on the previous parameters. Conclusion: Results demonstrated the beneficial effects of Ah preventive treatment against stress oxidative and kidney damage induced by BZ.

show abstract

Section: Discussionsupporting

confidence: 93%

Protective Role of Aqueous Extract of Atriplex Halimus L. Against Benzene-Induced Damage on Renal Function and Glomerular Cells in Rats

Zeghib

Boutlelis²

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…As a reason for our observation, liver enzymes ALT, AST, and ALP are known markers enzymes for the assessment of the functional integrity of the liver cells. The decrease of liver ALT activities after BZ exposure may be due to the leakage of this enzyme from the liver cytosol into the blood stream 19 . Liver cell membranes were damaged by benzene via the generation of ROS, leading to lipid peroxidation of biomembrane causing leakage of cellular components 20 .…”

Section: Discussionmentioning

confidence: 99%

Preventive and Curative Effects of Atriplex Halimus L. Aqueous Extract on Benzene Provoked Hepatic Injury in Rats

Zeghib

Ali²

2020

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Objective: The present study was designed to estimate the preventive and curative potency of aqueous extract of Atriplex halimus L. (Ah) aerial parts against benzene (BZ) intoxication in liver rats. Methods: 30 male albino rats were divided into five groups of 6 rats each: Control, Ah, BZ, AhP+BZ, and BZ+AhC. BZ (100 mg/kg b.w) was added in drinking water for 15 weeks. Aqueous extract of Atriplex halimus was received intragastrically during the last 30 days of BZ exposure for curative treatment (AhC) and all the duration of BZ exposure for preventive treatment (AhP). At the end the experiment, body weight gain and relative liver weight were estimated and liver enzyme markers (AST, ALT, ALP and LDH) were analysed by spectrophotometry. Histopathological studies on hepatic tissue were also performed by the method of Hematoxylin and Eosin staining. Results: Benzene administrated to rats caused an alteration in physiological parameters (body and organs weigh) and hepatic enzymes markers (AST, ALT, ALP and LDH). In addition, Histopathological studies showed a massive degeneration in liver tissue in BZ-exposed rats. However, treatment by Atriplex halimus especially preventive effect ameliorated most of the adverse effects induced by benzene. Ah restored the altered of physiological, biochemical and histopathological changes. Conclusion: The present study suggests that Atriplex halimus extract could be a substantially promising hepatoprotective agent against benzene toxic effects and may be against other hepatotoxic chemical or drugs. Keywords: Atriplex halimus, Benzene, hepatotoxicity, Rats.

show abstract

“…Benzene (250 mg/kg, b.w, p.o., for 50 days) also led to a considerable diminution in GSH levels and a significant elevation in MDA levels of liver and kidney tissues. GSE (50 and 150 mg/kg, b.w, p.o., for 50 days) significantly ameliorated the signs of hepatotoxicity, nephrotoxicity, and lipid peroxidation (Çavuşoğlu et al, ).…”

Section: Chemical‐induced Toxicitymentioning

confidence: 99%

Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review

Tabeshpour

Mehri

Behbahani

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

Vitis vinifera (grape) is one of the "most-produced fruit" in the world. Grape seeds are a valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its biologically active constituents, RSV, exert their protective effects against different natural or chemical toxins which could alter physiological homeostasis through a variety of mechanisms. Some of these mechanisms of actions include increase in superoxide dismutase, hemeoxygenase-1, and glutathione peroxidase activities and reduced glutathione content and decrease in malondialdehyde (MDA) levels and activation of the nuclear erythroid2-related factor2/ARE pathway. There are also various reports of the potential use of such compounds in preventing different ailments including cardiovascular diseases, cancer, degenerative diseases, and inflammatory disorders. Therefore, in this review, we have investigated the possible protective effects of grape and one of its biologically active constituents, RSV, on different organs' toxicity induced by natural toxins (such as mycotoxins, lipopolysaccharide, and triptolide) and chemical toxins (such as antitumors, metals, and carbon tetrachloride). There are insufficient clinical trials on this subject, so our review only includes in vivo and in vitro studies. To establish the grape beneficial effects in human intoxication, more clinical trials need to be accomplished.

show abstract

The effects of grape seed extract against toxicity of benzene on liver and kidney tissues of albino mice: biochemical evaluation

Cited by 4 publications

References 34 publications

Protective Role of Aqueous Extract of Atriplex Halimus L. Against Benzene-Induced Damage on Renal Function and Glomerular Cells in Rats

Protective Role of Aqueous Extract of Atriplex Halimus L. Against Benzene-Induced Damage on Renal Function and Glomerular Cells in Rats

Preventive and Curative Effects of Atriplex Halimus L. Aqueous Extract on Benzene Provoked Hepatic Injury in Rats

Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review

Contact Info

Product

Resources

About