The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel

Abstract

Konjac glucomannan (KGM) hydrogel has good potential application in food and medical science, although to achieve this, the physical and mechanical properties need further improvement. In this study, graphene oxide (GO) was used to improve the functionality of KGM hydrogel. KGM/GO hydrogels were prepared by freezing the alkaline KGM/GO sols. Rotational rheometer was used to study the rheological properties of different alkaline KGM/GO sols. Fourier transform infrared, Raman, differential scanning calorimetry, thermogravimetric analyses, and scanning electron microscopy were used to evaluate the structure and properties of the hydrogels. In addition, different pH solutions and an in vitro assay were used to study the swelling property and the release behavior of KGM/GO hydrogels, respectively. The result revealed strong hydrogen-bond interaction between KGM and GO. The incorporation of GO highly improved the gel properties of KGM/GO sol, higher thermal stability, and more compact structure of KGM/GO hydrogels. KGM/GO hydrogels showed better swelling properties in deionized-distilled water and pH 7.2 PBS. The release of 5-aminosalicylic acid (5-ASA) from KGM/GO (KG4) hydrogel was different in various pH media, but the initial burst release effect was very severe. Therefore, incorporation of GO have a good potential in enhancing the properties of KGM hydrogel, but KGM/GO hydrogel is not an ideal carrier for 5-ASA release.

A Review on Konjac Glucomannan Gels: Microstructure and Application

“…Due to the weak properties, pure Da-KGM hydrogel prepared by freeze-thawing method cannot meet actual applications, therefore, some additives are used in the procedure. graphene oxide (GO) is a common additive for enhancing properties of materials, Yuan et al [ 32 ] successfully prepared KGM/GO hydrogels by alkaline processing followed freeze-thawing, KGM/GO hydrogel showed a compact structure and decreased pore size comparing with pure KGM hydrogel. The porous structures of KGM/GO hydrogel had great specific surface area, and provided a possibility for drug storage and sustained delivery.…”

A Hydrogel Microneedle Assay Combined with Nucleic Acid Probes for On‐Site Detection of Small Molecules and Proteins

“…Next, to characterize the interaction between GO and MeHA hydrogel network, we performed Fourier Transform Infrared (FTIR) spectroscopy on hydrogel and hydrogel‐GO films (Figure 1F). GO contains carboxyl groups which can form hydrogen bonds with the amine and/or hydroxyl groups present in the MeHA hydrogel [36–38] . The N−H stretching vibration peak at 3300 in the hydrogel‐only spectrum has been shifted to 3305 in the hydrogel‐GO spectrum, indicating the formation of hydrogen bonds [36] .…”

“…GO contains carboxyl groups which can form hydrogen bonds with the amine and/or hydroxyl groups present in the MeHA hydrogel. [36][37][38] The NÀ H stretching vibration peak at 3300 in the hydrogel-only spectrum has been shifted to 3305 in the hydrogel-GO spectrum, indicating the formation of hydrogen bonds. [36] The NÀ H bending peak at 1610 has been also shifted to 1600 in the hydrogel-GO spectrum, further suggesting hydrogen bond formation between GO and the MeHA hydrogel.…”

Mussel-Inspired Fabrication of Konjac Glucomannan/Poly (Lactic Acid) Cryogels with Enhanced Thermal and Mechanical Properties

“…The sharpest band of the KPPA4 spectrum is 1622.1 cm −1 , which corresponds to the carbonyl stretching vibration. However, for the KPPA0, KPPA1, KPPA2, KPPA3 and KPPA4 cryogels, the stretching vibrations of –OH groups were generated at 3442.8, 3439.5, 3435.7, 3429.3 and 3425.6 cm −1 , respectively; while the bending vibrations of –C–H groups occurred at 1645.2, 1631.3, 1627.5,1627.2 and 1622.1 cm −1 [ 50 ], respectively. The shift of these absorption peaks indicated that the intermolecular hydrogen bonding between PDA and KGM/PLA molecular chains was formed in the cryogels.…”