The effects of guava (&lt;i&gt;Psidium guajava) consumption on total antioxidant and lipid profile in normal male youth

Rahmat, Asmah; Bakar,; Hambali, Zarida

doi:10.4314/ajfand.v6i2.71751

Cited by 23 publications

(24 citation statements)

References 11 publications

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“…Traditionally, the leaf extract was used as a tonic for the heart, analgesia and treatment for stomach ache (8). The extract is also known to have antioxidant properties (9, 10). Despite the wide and historical use of Carica papaya in the traditional management of many diseases, the scientific validation of its use as antioxidant is lacking.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Immunostimulant Effect of Carica Papaya Linn. Aqueous Extract in Acrylamide Intoxicated Rats

Sadek

2012

Acta Inform Med

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Introduction:The present study was conducted to evaluate the antioxidant and immunostimulant effects of The Carica papaya fruit aqueous extract (CPF, Caricaceae) against acrylamide induced oxidative stress and improvement of Immune functions which affected by free radicals liberating acrylamide in rats.Material and methods:Sixty male wistar albino rats (195-230g) were assigned to four groups, (fifteen/group). The first group used as control group and received normal physiological saline orally daily. The second group was supplemented with acrylamide 0.05% in drinking water. The third group was gastro-gavaged with 250 mg/kg of papaya fruit extract orally on daily basis. The fourth group was supplemented with acrylamide 0.05% in drinking water and gastro-gavaged with 250 mg/kg of papaya fruit extract orally on daily basis. The chosen dose of papaya fruit extract was based on the active pharmacological dose range obtained from the orientation study earlier conducted. The experimental period was extended to forty day. At the expiration of the experimental period and night fasting, blood samples were collected from the orbital venous sinus. The sera were separated and used for determining of IgG and IgM and the stomach, liver and kidney homogenates for estimation of MDA, GSH level, SOD and CAT activity as a biomarker of lipid peroxidation and antioxidative stress.Results and discussion:The obtained results revealed that, acrylamide caused significant increases in MDA and decrease of GSH level, SOD and CAT activity due to the oxidative stress induced by acrylamide on membrane polyunsaturated fatty acids in rat’s stomach, liver and kidney while administration of CPF aqueous extract, was significantly ameliorated the increased levels of MDA and decline of GSH, SOD and CAT activity in the stomach, liver and kidney tissues caused by acrylamide toxicity. Meanwhile, CPF aqueous extract significantly increased immune functions (IgG and IgM) while acrylamide significantly decrease it specially IgG. Thus, this study suggests that acrylamide-induced oxidative stress in rats can be ameliorated by administration of CPF aqueous extract.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Immunostimulant Effect of Carica Papaya Linn. Aqueous Extract in Acrylamide Intoxicated Rats

Sadek

2012

Acta Inform Med

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“…Throughout the combined stress test, SOD activity of shrimp in RR-3000 group was lower than that of the other group. In some cases, the reduction in antioxidant enzyme activities is associated with decreased oxidative stress and free-radical activity (Rahmat et al 2006). For example, some potential antioxidants, such as carotenoids, can decrease enzymatic antioxidant activity, which explains why wild shrimp with greater quantity and diversity of dietary carotenoids exhibit lower antioxidant enzyme activity (Ge et al 2009).…”

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confidence: 99%

Effects of dietary Rhodiola rosea on growth, body composition and antioxidant capacity of white shrimp Litopenaeus vannamei under normal conditions and combined stress of low-salinity and nitrite

et al. 2016

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An 8-week feeding trial followed by an acute combined stress of low-salinity and nitrite were designed to examine the effects of Rhodiola rosea on growth, body composition and antioxidant capacity of the white shrimp Litopenaeus vannamei. Shrimp (3.60 AE 0.03 g) were randomly allocated to 4 groups, with 3 replicates per group and 30 shrimp per replicate. The dietary groups were given as follows: control and diets containing R. rosea (300, 1000 and 3000 mg kg À1 ). Antioxidant capacity including total antioxidant status (TAS), activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) as well as gene expression of GSH-Px and CAT in hepatopancreas of shrimp was analysed at the end of feeding trial and again during the combined stress. The results showed that supplemental R. rosea had no significant impacts on growth and whole body composition of shrimp. There was significant effect of R. rosea supplementation dose and times on the antioxidant status parameters of L. vannamei. R. rosea (3000 mg kg À1 ) significantly improved the resistance of L. vannamei against the combined stress of low-salinity and nitrite, as indicated by the significant higher activities of TAS, GSH-Px and CAT (P < 0.05), as well as by the higher transcript levels of GPx and CAT gene (P < 0.05).

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“…Human study in Malaysia (Rahmat et al, 2006),investigating the effects of guava (Psidium guajava) consumption on total antioxidant status as indicated in (Table 5.1) and lipid profile (total cholesterol, triglycerides, LDLcholesterol and HDL-cholesterol) in 28 normal male youth the study was carried out over nine weeks, which was divided into three phases, that is, baseline (one week), treatment (four weeks) and control (four weeks).There was a significant increase of total antioxidants during the treatment phase, compared to the baseline and control phases (p < 0.05).The increase in total antioxidant status was probably due to increased antioxidant consumption contributed from guava which has been reported to be high in antioxidant vitamins such as ascorbic acid, β-carotene, lutein, zeaxanthin and lycopene. There were trends of reduction for both glutathione peroxidase and glutathione reductase in the treatment phase as compared to baseline and control phases.…”

Section: Human Study -Guava Fruit Extractsmentioning

confidence: 99%

A Systemic Review on Antioxidant and Hepato Protective Effect of Psidium Guajava Leaf and Fruit Extract

Molla¹

2017

JDMP

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Background: Plant derived natural products such as flavonoids, terpenoids, carbohydrates, tannins, saponins, steroids, proteins, amino acids and Vitamin C have received considerable attention in recent years due to their diverse pharmacological properties including antioxidant and hepatoprotective activity. Psidium guajava (Myrtaceae) is one of such plants in folk medicine that has been used for the management of various disease conditions. Various parts of the plant has been used in traditional medicine .Antioxidants from medicinal plants play an important role in inhibiting and scavenging radicals, thus providing protection to human against infection and degeneration diseases. Objective: To review the antioxidant and hepatoprotective activity of psidium guajava. Methods: Computerised literature search was conducted using PubMed, Medline and Google search engine using different key words for studies investigating the antioxidant and hepatoprotective activities of Psidium guajava using the following as heading terms, psidium guajava, antioxidant, hepatoprotectie, Liver injury, oxidative stress. In addition, the reference lists of the retrieved articles helped me to find further articles, relevant to the present review that was not revealed through the searching procedure. Result: Out of a total of 152 articles on guava resulted 19 studies which were related to antioxidant and hepatoprotective activity of leaf and fruit extract were included in this review. These were then categorized into six groups; 1) Six studies on in vitro antioxidant studies with leaf extracts, 2) four studies on in vitro antioxidant studies with fruit extract, 3) one in vivo study on antioxidant with leaf extract in rat, 4) one in vivo study on antioxidant with fruit extract in rat, 5) one study antioxidant fruit extract in human and 6) six in vivo studies on hepatoprotective with leaf extract in rat. Conclusion:The antioxidant activity of Psidium guajava may be due to inhibition of the formation of radicals, scavenging of the formed free radicals, reducing of oxidized intermediates and the presence of the phenolic compounds. It also acts as promising hepato protective which is correlated directly with its ability to reduce activity of serum enzymes and enhance antioxidant defense status. The phenolic content in Psidium guajava extract played a significant role on the antioxidant and hepatoprotective activity.

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The effects of guava (<i>Psidium guajava) consumption on total antioxidant and lipid profile in normal male youth

Cited by 23 publications

References 11 publications

Antioxidant and Immunostimulant Effect of Carica Papaya Linn. Aqueous Extract in Acrylamide Intoxicated Rats

Antioxidant and Immunostimulant Effect of Carica Papaya Linn. Aqueous Extract in Acrylamide Intoxicated Rats

Effects of dietary Rhodiola rosea on growth, body composition and antioxidant capacity of white shrimp Litopenaeus vannamei under normal conditions and combined stress of low-salinity and nitrite

A Systemic Review on Antioxidant and Hepato Protective Effect of Psidium Guajava Leaf and Fruit Extract

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