The Effects of Halofuginone and Salinomycin, Alone and in Combination, on Live Performance and Skin Characteristics of Broilers

Pinion, J. L.; Bilgili, S. F.; Eckman, M. K.; Hess, J. B.

doi:10.3382/ps.0740391

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…Relative humidity, for example, influences the incidence and severity of foot-pad burn (Weaver and Meijerhof, 1991), and different food has been shown to influence the strength of the skin (Pinion et al, 1995). Therefore, some birds might be less susceptible to dermal lesions than others.…”

Section: Effects Of Supermarkets Conventional Vs 'Organic' Rearing Amentioning

confidence: 99%

Chicken welfare as indicated by lesions on carcases in supermarkets

Reefmann

2005

British Poultry Science

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1. The extent of visible lesions in British broiler carcases was investigated in order to discover the extent of any poor welfare. It is well established that hock burn and some other injuries can occur during housing of broiler chickens, whilst other injuries can occur during handling. 2. Three hundred and eighty-four whole conventionally reared British Farm Standard Grade A chickens were scrutinised in supermarkets to assess the frequency of 15 kinds of lesions. Six lesions were analysed histopathologically and this showed that hock burn would have occurred several days pre-mortem, red alular and wrist bruise were very likely to have occurred pre-mortem, whilst red parson's nose and scratches were likely to have occurred pre-mortem. 3. Many broiler carcases in the supermarkets had dermal lesions: 0.82 had hock burns, 0.45 a red parson's nose, 0.32 a red alular, 0.21 wrist bruises and 0.21 had at least one scratch on a leg. The frequency of the larger hock burns increased with body weight. 'Organic' chickens had half as many hock burns as conventionally reared broilers, perhaps because of differences in litter quality or leg strength. 4. The sample studied indicates that painful lesions which would result in poor welfare are frequent in broilers slaughtered in the UK. The Grade A chickens observed exclude birds with obvious visible defects because these birds would have had the blemishes removed and the carcase would have been portioned. Hence the frequencies of lesions in farmed birds would be higher than those reported here.

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Section: Effects Of Supermarkets Conventional Vs 'Organic' Rearing Amentioning

confidence: 99%

Chicken welfare as indicated by lesions on carcases in supermarkets

Reefmann

2005

British Poultry Science

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“…2E). In addition to its antimalarial properties, HF is an FDA-approved feed additive to suppress coccidiosis in poultry production (120). HF binds with high specificity to the prolyl-tRNA synthetase active site and is a potent inhibitor of proline incorporation in protein synthesis (43).…”

Section: Malaria As a Target Of Anti-ars Compoundsmentioning

confidence: 99%

Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics

Francklyn

Mullen

2019

Journal of Biological Chemistry

113

104

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Edited by Karin Musier-Forsyth Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze the attachment of amino acids to the 3 ends of their cognate tRNAs. The resulting aminoacylated tRNAs are escorted to the ribosome where they enter protein synthesis. By specifically matching amino acids to defined anticodon sequences in tRNAs, ARSs are essential to the physical interpretation of the genetic code. In addition to their canonical role in protein synthesis, ARSs are also involved in RNA splicing, transcriptional regulation, translation, and other aspects of cellular homeostasis. Likewise, aminoacylated tRNAs serve as amino acid donors for biosynthetic processes distinct from protein synthesis, including lipid modification and antibiotic biosynthesis. Thanks to the wealth of details on ARS structures and functions and the growing appreciation of their additional roles regulating cellular homeostasis, opportunities for the development of clinically useful ARS inhibitors are emerging to manage microbial and parasite infections. Exploitation of these opportunities has been stimulated by the discovery of new inhibitor frameworks, the use of semi-synthetic approaches combining chemistry and genome engineering, and more powerful techniques for identifying leads from the screening of large chemical libraries. Here, we review the inhibition of ARSs by small molecules, including the various families of natural products, as well as inhibitors developed by either rational design or highthroughput screening as antibiotics and anti-parasitic therapeutics.

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“…In the 1960s, a number of analogues of febrifugine, such as halofuginone, were synthesized in the USA. [1][2][3][4] Halofuginone is a synthetic derivative of quinazolinone alkaloid febrifugine. Febrifugine has been used to treat fever and malaria for more than 2000 years.…”

Section: Introductionmentioning

confidence: 99%

Geometry, tautomerism and non-covalent interactions of the drug halofuginone with the carbon-nanotube and γ-Fe2O3 nanoparticles: A DFT study

Kazeri-shandiz

Beyramabadi

Morsali

2018

JSCS

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Halofuginone is a potential anti-malarial drug, which could exist as three possible tautomers. Herein, using density functional theory (DFT), and handling the solvent effects with the PCM model, the tautomerism of halofuginone was investigated. Intramolecular H-bonds play an important role in the stability of the tautomers. The conformer H1a is the most stable. Noncovalent interactions of the H1a conformer with the armchair (5,5) single-wall carbon nanotubes and γ-Fe 2 O 3 nanoparticles were explored in several manners. The most stable form of them was determined. The intermolecular H-bonds play a substantial role in the energy behavior of the interaction between γ-Fe 2 O 3 nanoparticles and halofuginone.

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The Effects of Halofuginone and Salinomycin, Alone and in Combination, on Live Performance and Skin Characteristics of Broilers

Cited by 11 publications

References 9 publications

Chicken welfare as indicated by lesions on carcases in supermarkets

Chicken welfare as indicated by lesions on carcases in supermarkets

Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics

Geometry, tautomerism and non-covalent interactions of the drug halofuginone with the carbon-nanotube and γ-Fe2O3 nanoparticles: A DFT study

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