The effects of haloperidol on visual search, eye movements and psychomotor performance

Lynch, Gordon S.; King, David J.; Green, J. F.; Byth, William; Wilson-Davis, K

doi:10.1007/s002130050396

Cited by 24 publications

(19 citation statements)

References 20 publications

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“…Although several authors reported psychomotor impairments with similar doses in older volunteers 18,22 or with higher doses in healthy subjects within the same age range, 17,19 the absence of impeding effects 17,21,48 or even the presence of an improvement 20 with lower doses of haloperidol in younger subjects has been documented as well. Our volunteers did display a mild deterioration of performance on the more taxing pursuit task, which tests 3 psychomotor skills concurrently, that is, visuospatial monitoring, sensorimotor speed, and accuracy.…”

Section: Discussionmentioning

confidence: 92%

“…Indeed, both the effects of typical and atypical antipsychotics on the psychomotor skills of healthy controls have been documented before. Thus, haloperidol has repeatedly been demonstrated to impair the psychomotor performance of healthy controls, [15][16][17][18][19] although studies using doses of less than 3 mg of haloperidol did not find any impairing effects. [20][21][22] Olanzapine, on the other hand, was also shown to affect psychomotor function in healthy volunteers but only in the first few days after intake, 18 as opposed to the continuing deterioration of psychomotor function observed after repeated dosages of haloperidol.…”

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confidence: 99%

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Psychomotor and Memory Effects of Haloperidol, Olanzapine, and Paroxetine in Healthy Subjects After Short-Term Administration

Morrens¹,

Wezenberg²,

Verkes³

et al. 2007

Journal of Clinical Psychopharmacology

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Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 99%

Psychomotor and Memory Effects of Haloperidol, Olanzapine, and Paroxetine in Healthy Subjects After Short-Term Administration

Morrens¹,

Wezenberg²,

Verkes³

et al. 2007

Journal of Clinical Psychopharmacology

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“…It has recently been reported that a simple manual reaction time task is delayed in PD patients as a result of subcutaneous apomorphine injection, a D1 and D2 receptor agonist (Muller et al 2002), and similarly apomorphine has been reported to impair the reaction time in certain strains of rats (Wilcox and Spirduso 1988). Amphetamine causes dopamine release and reuptake inhibition, and has been found to prolong saccadic latencies in humans (Dursun et al 1999), whereas haloperidol, a dopamine antagonist with mild anticholinergic action, has been found not to affect saccades (Lynch et al 1997). …”

Section: The Effect Of L-dopa On Latency Distributionsmentioning

confidence: 99%

Saccadic latency distributions in Parkinson’s disease and the effects of l-dopa

Michell

Fritz

et al. 2006

Exp Brain Res

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Parkinson's disease (PD) is associated with a loss of central dopaminergic pathways in the brain leading to an abnormality of movement, including saccades. In PD, analysis of saccadic latency distributions, rather than mean latencies, can provide much more information about how the neural decision process that precedes movement is affected by disease or medication. Subject to the constraints of intersubject variation and reproducibility, latency distribution may represent an attractive potential biomarker of PD. Here we report two studies that provide information about these parameters, and demonstrate a novel effect of dopamine on saccadic latency, implying that it influences the neural decision process itself. We performed a detailed cross-sectional study of saccadic latency distributions during a simple step task in 22 medicated patients and 27 agematched controls. This revealed high intersubject variability and an overlap of PD and control distributions. A second study was undertaken on a different population specifically to investigate the effects of dopamine on saccadic latency distributions in 15 PD patients. L-dopa was found to prolong latency, although the magnitude of the effect varied between subjects. The implications of these observations for the use of saccadic latency distributions as a potential biomarker of PD are discussed, as are the effects of L-dopa on neural decision making, where it is postulated to increase the criterion level of evidence required before the decision to move is made.

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“…Intelligence Scale (Wechsler, 1955) was administered to the patients and healthy controls as a probe sensitive to the administered drugs sedative effects (Mattila et al, 1988;Lynch et al, 1997;Busto et al, 2000).…”

Section: Clinical Assessment and Selection Principlesmentioning

confidence: 99%

EEG spectral power and mean frequencies in early heroin abstinence

Polunina

Davydov

2004

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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The purpose of the present study was to investigate cumulative heroin effects on brain functioning by studying relationships between EEG spectral power and mean frequencies and heroin abusing history. Eyes closed resting EEG data were collected from the 19 monopolar electrode sites in 33 heroin abusers and 13 age-matched healthy volunteers. The mean age of the patients was 23.1±4.5, the duration of daily heroin abuse (DDHA) ranged from 4 to 44 months, the i.v. doses of heroin ranged from 0.04 to 1.00 g/day, the abstinence length ranged from 6 days to 4.5 months. GLM repeated measures procedure revealed a significant group effect on the distribution of the mean power spectrum between bands and mean frequencies in almost all analyzed derivations. Further analysis demonstrated that these intergroup differences were diversely related to at least three aspects of heroin taking history. Frequency shifts in alpha2 range, most prominent in frontal and central derivations, were related to duration of daily heroin consumption. Slowing of alpha1 mean frequency, most prominent in central, temporal and occipital derivations, was registered mainly in heroin addicts who abused high doses of the drug. Spectral power characteristics of brain electrical activities in our patient population were strongly predicted by abstinence length. The present results give grounds to suppose that chronic heroin taking induces neuronal oscillation frequency changes, that may contribute to the development of antisocial trends and some semantic processes disturbances in these patients. Supplementary neurophysiological deficit is characteristic for heroin addicts, who takes high doses of the drug, however, its relation to heroin abusing remains unclear. Pronounced desynchronization is observed in acute heroin withdrawal, and spectral power characteristics tend to normalize almost completely during several weeks of abstinence.

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The effects of haloperidol on visual search, eye movements and psychomotor performance

Cited by 24 publications

References 20 publications

Psychomotor and Memory Effects of Haloperidol, Olanzapine, and Paroxetine in Healthy Subjects After Short-Term Administration

Psychomotor and Memory Effects of Haloperidol, Olanzapine, and Paroxetine in Healthy Subjects After Short-Term Administration

Saccadic latency distributions in Parkinson’s disease and the effects of l-dopa

EEG spectral power and mean frequencies in early heroin abstinence

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