The Effects of Halothane, Trichloroethylene and Ether on the Hypoxic Pressor Response and Pulmonary Vascular Resistance in the Isolated, Perfused Cat Lung

Sykes, M.K.; Davies, D.M.; Chakrabarti, M.K.; Loh, L.

doi:10.1093/bja/45.7.655

Cited by 39 publications

(16 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No study has investigated the influence of chloralose on the pulmonary circulation. Previous studies regarding the effects of anesthesia on hypoxic pulmonary vasoconstriction have concentrated on evaluating the effects of inhalational anesthetic agents (29)(30)(31)(32). The influence of intravascular anesthetic agents on hypoxic pulmonary vasoconstriction has been infrequently studied (32)(33)(34).…”

Section: Pulmonary Vascular Resistancementioning

confidence: 99%

Chloralose Alters Both Basal Hemodynamics and Cardiovascular Responses to Alveolar Hypoxia in Chronically Instrumented, Spontaneously Breathing Lambs'

et al. 1989

View full text Add to dashboard Cite

ABSTRACT. We studied the effects of chloralose anesthesia on the basal hemodynamic state and on the cardiovascular response to alveolar hypoxia in chronically instrumented, spontaneously breathing lambs, compared with responses to the saline vehicle. Chloralose significantly increased heart rate (23%), mean systemic arterial pressure (]I%), systemic vascular resistance (21%), mean pulmonary arterial pressure (23%), and pulmonary vascular resistance (46%) (n = 30, p < 0.05, ANOVA). These changes were unrelated to baseline tone of the circulation, cardiac output, mean left atrial pressure, or physiologically important changes in arterial blood gas tensions. In addition, chloralose-treated lambs had increased heart rate, systemic vascular resistance, and pulmonary vascular resistance compared to controls during alveolar hypoxia (13-15% FiOz). Importantly, chloralose-treated lambs did not increase their cardiac output during alveolar hypoxia a s did control lambs. During hypoxia, systemic vascular resistance remained elevated in chloralose-treated lambs, but declined in control lambs. Chloralose has been recommended a s an ideal anesthetic agent for cardiovascular experimentation. Our data suggest that chloralose-induced alterations in basal hemodynamics and in cardiovascular responses to alveolar hypoxia represent an uncontrolled variable in acute experimental studies. Complex cardiovascular alterations caused by anesthesia should be considered in experimental design. (Pediatr Res 25389-395, 1989) Abbreviations PVR, pulmonary vascular resistance SVR, systemic vascular resistance

show abstract

Section: Pulmonary Vascular Resistancementioning

confidence: 99%

Chloralose Alters Both Basal Hemodynamics and Cardiovascular Responses to Alveolar Hypoxia in Chronically Instrumented, Spontaneously Breathing Lambs'

et al. 1989

View full text Add to dashboard Cite

show abstract

“…a local precapillary vasoconstriction ( KATO & STAUB 1966) within hypoxic regions of the lungs. SYKES et al (1972SYKES et al ( ,1973 havesuggested that the pulmonary vasoconstrictor response to acute alveolar hypoxia is abolished in the lungs of dogs and cats by some commonly used inhalation anesthetics. The importance of these reports, however, is limited by the qualitative description : no account is given which correlates the reduction of responses to the concentrations of anesthetics.…”

Section: Receivrd 17 May Accepted For Publication I4 June 1976mentioning

confidence: 99%

Hypoxia‐induced Vasoconstriction in Isolated Perfused Lungs exposed to Injectable or Inhalation Anesthetics

Bjertnæs¹

1977

Acta Anaesthesiol Scand

106

View full text Add to dashboard Cite

Investigations during the last two decades have revealed a tendency to inpaired pulmonary gas exchange in patients during general anesthesia. In the awake state, arterial hypoxemia is counteracted by a mechanism which tends to normalize the ventilation/perfusion ratio of the lungs by way of a hypoxia-induced vasoconstriction in poorly ventilated areas. This results in a redistribution of perfusion to more adequately ventilated lung regions. Recent observations suggest, however, that this beneficial mechanism is blunted by some commonly used inhalation anesthetics. In the present study the effect of inhalation anesthetics and injectable anesthetics on the vasoconstrictor response to acute alveolar hypoxia have been compared in isolated blood-perfused rat lungs. The experiments showed that the response was unaffected by N2O and injectable anesthetics, while a reversible, dose-dependent damping effect was demonstrated for the volatile inhalation anesthetics, ether, halothane and methoxyflurance. The effect could be demonstrated at blood concentrations comparable to those used in clinical anesthesia, and it was not due to a general paralysis of the vascular smooth muscle. The findings might, at least in part, explain the occurrence of arterial hypoxemia during general inhalation anesthesia.

show abstract

“…A constant-flow isolated lung perfusion was then established (Sykes et al, 1973). In this technique the lungs are perfused in situ with a constant flow of oxygenated blood at 37 °C and airway (P^y), mean pulmonary artery (Ppx) and mean left atrial (P^A) pressures are measured to enable changes in pulmonary vascular resistance (PVR) to be determined.…”

Section: Methodsmentioning

confidence: 99%

“…Support for this hypothesis has been provided by studies which have shown that anaesthetic concentrations of halothane, trichloroethylene, ether, methoxyflurane and nitrous oxide depress reversibly the pulmonary vasoconstrictor response to alveolar hypoxia in the isolated, perfused cat lung (Sykes et al, 1973(Sykes et al, , 1976Gibbs, Sykes and Tait, 1974;Hurtig, Tait and Sykes, 1977;Hurtig et al, 1977) or innervated perfused lung (Loh, Sykes and Chakrabarti, 1977). It has been shown also that trichloroethylene 1%, ether 5% and nitrous oxide exert a similar effect in the intact dog (Sykes et al, 1975(Sykes et al, , 1977a.…”

mentioning

confidence: 94%

Effect of Cyclopropane on Pulmonary Vascular Resistance and Hypoxic Pulmonary Vasoconstriction in the Isolated Perfused Cat Lung

Tait¹,

Chakrabarti²,

Sykes³

1978

British Journal of Anaesthesia

Self Cite

View full text Add to dashboard Cite

show abstract

The Effects of Halothane, Trichloroethylene and Ether on the Hypoxic Pressor Response and Pulmonary Vascular Resistance in the Isolated, Perfused Cat Lung

Cited by 39 publications

References 15 publications

Chloralose Alters Both Basal Hemodynamics and Cardiovascular Responses to Alveolar Hypoxia in Chronically Instrumented, Spontaneously Breathing Lambs'

Chloralose Alters Both Basal Hemodynamics and Cardiovascular Responses to Alveolar Hypoxia in Chronically Instrumented, Spontaneously Breathing Lambs'

Hypoxia‐induced Vasoconstriction in Isolated Perfused Lungs exposed to Injectable or Inhalation Anesthetics

Effect of Cyclopropane on Pulmonary Vascular Resistance and Hypoxic Pulmonary Vasoconstriction in the Isolated Perfused Cat Lung

Contact Info

Product

Resources

About