The effects of handling and storage on magnesium based implants — First results

Ullmann, Berit; Angrisani, Nina; Reifenrath, Janin; Seitz, Jan‐Marten; Bormann, Dirk; Bach, Friedrich‐Wilhelm; Meyer‐Lindenberg, Andrea

doi:10.1016/j.msec.2013.03.034

Cited by 9 publications

(7 citation statements)

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“…During ongoing storage, a significant reduction in magnesium could be detected by SEM/EDX analysis, combined with an increase in oxygen-rich regions (24 weeks of storage increased this by a factor of 6.6 and 48 weeks of storage increased it by a factor of 1.1). Similar results were described by Ullmann et al [ 7 ]. Most likely magnesium oxides or magnesium hydroxide layers formed on the samples surfaces during storage in this study, as it is known to occur on Mg surfaces under atmospheric conditions [ 32 ].…”

Section: Discussionsupporting

confidence: 92%

“…The results showed that high relative humidity and low temperature (<100 °C) encouraged corrosion of the implant surface. Ullman et al [ 7 ] showed that with increasing storage duration of LANd442 pins, there was an increase in the number of oxygen enriched regions on the implant surface, in the mean grain size of the metal, and in the levels of precipitations (such as aluminum/lithium or rare earth elements).…”

Section: Introductionmentioning

confidence: 99%

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The influence of storage and heat treatment on a magnesium-based implant material: an in vitro and in vivo study

et al. 2015

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BackgroundMagnesium alloys are recommended as a potential material for osteosynthesis. It is known that storage-induced property modifications can occur in materials like aluminum. Thus the aim of this study was to analyze the influence of storage durations of up to 48 weeks on the biomechanical, structural, and degradation properties of the degradable magnesium alloy LAE442.MethodsExtruded implants (n = 104; Ø 2.5 mm × 25 mm) were investigated after storage periods of 0, 12, 24, and 48 weeks in three different sub-studies: (I) immediately after the respective storage duration and after an additional (II) 56 days of in vitro corrosion in simulated body fluid (SFB), and (III) 48 weeks in vivo corrosion in a rabbit model, respectively. In addition, the influence of a T5-heat treatment (206 °C for 15 h in an argon atmosphere) was tested (n = 26; 0 week of storage). Evaluation was performed by three-point bending, scanning electron microscopy, radiography, µ-computed tomography, evaluation of the mean grain size, and contrast analysis of precipitations (such as aluminum or lithium).ResultsThe heat treatment induced a significant reduction in initial stability, and enhanced the corrosion resistance. In vivo experiments showed a good biocompatibility for all implants. During the storage of up to 48 weeks, no significant changes occurred in the implant properties.ConclusionsLAE442 implants can be safely used after up to 48 weeks of storage.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The influence of storage and heat treatment on a magnesium-based implant material: an in vitro and in vivo study

et al. 2015

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“…But due to gas formation resulting from the magnesium´s degradation, formation of cavities, surrounded by tiny fibrous capsule was observed. Degradation of LAE442 alloy implants occurred in vivo and even ex vivo despite fixation and embedding processes [60]. The bone marrow cavity was filled with prominent gas cavities, surrounded by fibrous septa (Fig.…”

Section: Histologymentioning

confidence: 99%

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

et al. 2015

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“…Quality management standards, such as ISO 13485, where the regulatory requirements for medical device development are defined, and ISO 14971, where management of risk associated with a device is defined, drive most large organizations to develop their own quality management and risk evaluation processes (Bernardo, Casadesus, Karapetrovic & Heras, 2012; Guijarro, López-Rodríguez, Moral, Mena & Álvarez, 2012; Ullmann et al, 2013; Westgard, 2013). Returns from creating such a synergistic system can further be mapped in terms of patient experience, staff experience or even the impact on the bottom line for the equipment manufacturer and using organization (Bernardo, Casadesus, Karapetrovic & Heras, 2008; Jørgensen, Remmen & Mellado, 2006; McCarthy et al, 2016; Zeng, Shi & Lou, 2007).…”

Section: Literature Reviewmentioning

confidence: 99%

A Case in Medical Equipment Design for Strategic Sustainability

Mann

Gullaiya

2018

South Asian Journal of Business and Management Cases

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The alignment of strategic sustainability goals can be very challenging for industries where stringent product requirements restrict the ability to innovate environmentally friendly alternatives. This case studies an instance of medical equipment being designed to increase functionality and decrease disposability, creating greater utility. The primary outcome of this research is a demonstration that cost is not prohibitive when introducing reusable medical tools and equipment when innovative solutions satisfy stringent standards and can provide superior functionality.

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The effects of handling and storage on magnesium based implants — First results

Cited by 9 publications

References 43 publications

The influence of storage and heat treatment on a magnesium-based implant material: an in vitro and in vivo study

The influence of storage and heat treatment on a magnesium-based implant material: an in vitro and in vivo study

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

A Case in Medical Equipment Design for Strategic Sustainability

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