The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies

Porru, Simona; Esplugues, Ana; Llop, Sabrina; Delgado-Saborit, Juana María

doi:10.1016/j.envpol.2024.123732

Cited by 8 publications

(2 citation statements)

References 113 publications

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“…Environmental factors such as pollutants, chemicals, and microbial exposures may alter the composition and activity of gut microbiota. For example, prolonged exposure to heavy metals or toxic chemicals may lead to imbalance of gut microbiota, reducing beneficial microbial communities and increasing harmful microbial communities, thereby exacerbating the risk of tumor development (Kaur and Rawal, 2023;Porru et al, 2024).…”

Section: Discussionmentioning

confidence: 99%

Refining the relationship between gut microbiota and common hematologic malignancies: insights from a bidirectional Mendelian randomization study

Chen,

Guo,

Wang

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundThe relationship between gut microbiota and hematologic malignancies has attracted considerable attention. As research progresses, it has become increasingly clear that the composition of gut microbiota may influence the onset and progression of hematologic malignancies. However, our understanding of this association remains limited.MethodsIn our study, we classified gut microbiota into five groups based on information at the phylum, class, order, family, and genus levels. Subsequently, we obtained data related to common hematologic malignancies from the IEU Open GWAS project. We then employed a bidirectional Mendelian Randomization (MR) approach to determine whether there is a causal relationship between gut microbiota and hematologic malignancies. Additionally, we conducted bidirectional MR analyses to ascertain the directionality of this causal relationship.ResultsThrough forward and reverse MR analyses, we found the risk of lymphoid leukemia was significantly associated with the abundance of phylum Cyanobacteria, order Methanobacteriales, class Methanobacteria, family Peptococcaceae, family Methanobacteriaceae, and genera Lachnospiraceae UCG010, Methanobrevibacter, Eubacterium brachy group, and Butyrivibrio. The risk of myeloid leukemia was significantly associated with the abundance of phylum Actinobacteria, phylum Firmicutes, order Bifidobacteriales, order Clostridiales, class Actinobacteria, class Gammaproteobacteria, class Clostridia, family Bifidobacteriaceae, and genera Fusicatenibacter, Eubacterium hallii group, Blautia, Collinsella, Ruminococcus gauvreauii group, and Bifidobacterium. The risk of Hodgkin lymphoma was significantly associated with the abundance of family Clostridiales vadinBB60 group, genus Peptococcus, and genus Ruminococcaceae UCG010. The risk of malignant plasma cell tumor was significantly associated with the abundance of genera Romboutsia and Eubacterium rectale group. The risk of diffuse large B-cell lymphoma was significantly associated with the abundance of genera Erysipelatoclostridium and Eubacterium coprostanoligenes group. The risk of mature T/NK cell lymphomas was significantly associated with the abundance of phylum Verrucomicrobia, genus Ruminococcaceae UCG013, genus Lachnoclostridium, and genus Eubacterium rectale group. Lastly, the risk of myeloproliferative neoplasms was significantly associated with the abundance of genus Coprococcus 3 and Eubacterium hallii group.ConclusionOur study provided new evidence for the causal relationship between gut microbiota and hematologic malignancies, offering novel insights and approaches for the prevention and treatment of these tumors.

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Section: Discussionmentioning

confidence: 99%

Refining the relationship between gut microbiota and common hematologic malignancies: insights from a bidirectional Mendelian randomization study

Chen,

Guo,

Wang

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Early life exposure to high levels of Mn is thought to impact neurodevelopment, especially cognitive behavior in children [127]. Importantly, high Mn exposure and alteration in the GM has been linked to oxidative stress and neuroinflammation, which are implicated in HD [128,129].…”

Section: Manganese (Mn) -Hdmentioning

confidence: 99%

Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Tizabi,

Bennani,

El Kouhen

et al. 2024

Preprint

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Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative disease characterized by involuntary movements, cognitive decline, executive dysfunction, and neuropsychiatric conditions such as anxiety and depression. It follows an autosomal dominant inheritance pattern. Thus, a child who has a parent with the mutated huntingtin (mHTT) gene has a 50% chance of developing the disease. Since HTT protein is involved in many critical cellular processes including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, and autophagy, its aberrant aggregates lead to disruption of numerous cellular pathways and neurodegeneration. Essential heavy metals are vital at low concentrations, however, at higher concentrations, can exacerbate HD by disrupting the glial-neuronal communication, and/or causing dysbiosis (disturbance in the gut microbiota, GM), both of which can lead to neuroinflammation and further neurodegeneration. Here, we discuss in detail the interactions of iron, manganese and copper with glial-neuron communication and GM and indicate how this knowledge may pave the way for development of a new generation of disease-modifying therapies in HD.

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Heavy metals in spices and herbs from worldwide markets: A systematic review and health risk assessment

Alawadhi,

Abass,

Khaled

et al. 2024

Environmental Pollution

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The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies

Cited by 8 publications

References 113 publications

Refining the relationship between gut microbiota and common hematologic malignancies: insights from a bidirectional Mendelian randomization study

Refining the relationship between gut microbiota and common hematologic malignancies: insights from a bidirectional Mendelian randomization study

Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Heavy metals in spices and herbs from worldwide markets: A systematic review and health risk assessment

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