The effects of helicobacter pylori infection on nutrition status and metabolism

Özturan, Ayçıl; Bilici, Saniye

doi:10.5505/kjms.2017.03411

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…The protective role of appetite loss may however be contributed to by the several possible causes of appetite loss in these children, like being on several medicines which may also reduce H. pylori infection, and other factors which were not studied in details. In addition, certain foods and nutrients like fruits and vegetables have been found to be effective for the prevention and eradication therapy of H. pylori , partly because of their antioxidant effect 25 . These foods are commonly used for children who have lost appetite to help boost their appetites.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with Helicobacter Pylori infection among children with sickle cell anemia attending Mulago hospital, in Uganda

Mubiru¹,

Kasirye²,

Hume³

et al. 2022

Afr H. Sci.

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Background: Children with sickle cell anemia (SCA) have a high predisposition to a range of infections and gastrointestinal disorders. Studies of children living in low income countries have shown high levels of infection with Helicobacter Pylori (H.pylori), however, there are no reports in Ugandan children with SCA. Objectives: We aimed to describe the prevalence and factors associated with H. pylori infection among children with SCA at Mulago Hospital. Methods: A cross-sectional study was conducted on 340 children with SCA aged 5-18 years. Assessments included recurrent abdominal pain(RAP), dyspeptic symptoms, relevant medical and social histories. Stool samples were collected and an antigen test carried out to determine H. pylori infection. H. pylori prevalence and its associated factors were determined. Results: Helicobacter pylori infection was detected in 49%(168/340); (95%Confidence interval (CI): 44.1, 54.7) of the study subjects. Having epigastric pain was independently associated with H. pylori infection; (Adjusted odds ratio [aOR] = 1.89; 95%CI: 1.1, 3.6; p= 0.048). Pneumococcal vaccination; (aOR=0.425; 95%CI: 0.2, 0.9; p=0.019) and appetite loss; (aOR=0.588; 95%CI: 0.3, 0.9; p=0.046) were negatively associated with H. pylori infection. RAP was not associated with H.pylori infection. Conclusions: H. pylori infection was common among children with SCA and independently associated with epigastric pain but not recurrent abdominal pain. Pneumococcal vaccination and appetite loss were protective against the infection. Screening for H. pylori should be carried out in SCA children with epigastric pain. Keywords: Recurrent abdominal pain; Sickle cell anemia; Dyspeptic symptoms.

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Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with Helicobacter Pylori infection among children with sickle cell anemia attending Mulago hospital, in Uganda

Mubiru¹,

Kasirye²,

Hume³

et al. 2022

Afr H. Sci.

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Investigating Helicobacter pylori-related pyloric hypomotility: functional, histological, and molecular alterations

Ashraf

Gamal

Ashour

et al. 2021

American Journal of Physiology-Gastrointestinal and Liver Physi

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Multiple theories have been proposed describing the pathogenic mechanisms of Helicobacter pylori (H. pylori)-associated gastric motility disorders. We assessed ex-vivo pyloric activity in h.pylori infected rats, and tried to explore the associated ghrelin hormone alteration and pyloric fibrogenesis. In addition, miR-1 was assessed in pyloric tissue samples, being recently accused of having a role in smooth muscle dysfunction. Ninety adult male Wistar albino rats were assigned into 9 groups: 1)Control group, 2)Sterile broth (vehicle group), 3)amoxicillin control, 4) omeperazole control, 5)clarithromycin control, 6)triple therapy control, 7)H. pylori- group, 8)H. pylori-clarithromycin group, and 9)H.pylori-triple therapy group. Urease enzyme activity was applied as an indicator of H. pylori infection. Ex-vivo pyloric contractility was evaluated. Serum ghrelin was assessed, and histological tissue evaluation was performed. Besides, pyloric muscle miR-1 expression was measured. The immunological epithelial to mesenchymal transition (EMT) markers; transforming growth factor β (TGFβ), alpha-smooth muscle actin (α-SMA) and E-cadherin-3 were also evaluated. By H. pylori infection, a significant (P<0.001) reduced pyloric contractility index was recorded. The miR-1 expression was decreased (P<0.001) in the H. pylori-infected group, associated with reduced serum ghrelin, elevated TGFβ, and α-SMA levels and reduced E-cadherin levels. Decreased miR-1 and disturbed molecular pattern were improved by treatment. In conclusion: H. pylori infection was associated with reduced miR-1, epithelial to mesenchymal transition, and pyloric hypomotility. The miR-1 may be a target for further studies to assess its possible involvement in H.pylori associated pyloric dysfunction, which might help in management of human H. pylori manifestations and complications.

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The effects of helicobacter pylori infection on nutrition status and metabolism

Abstract: H.pylori infection, which is common in the world as well as in our country and has been identified as a group 1 carcinogen by the

Cited by 2 publications

References 55 publications

Prevalence and factors associated with Helicobacter Pylori infection among children with sickle cell anemia attending Mulago hospital, in Uganda

Prevalence and factors associated with Helicobacter Pylori infection among children with sickle cell anemia attending Mulago hospital, in Uganda

Investigating Helicobacter pylori-related pyloric hypomotility: functional, histological, and molecular alterations

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