The effects of Helicobacter pylori infection on intraocular pressure in anterior uveitis

Kim, J M; Park, K H; Choi, Moonjung; Ha, Minji; Sohn, Yong Ho; Kim, H K

doi:10.1038/eye.2012.206

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…This increased IOP resolved in the group treated with bolus VAN and our VAN DDS after 24 hours but persisted in the two control groups (saline and blank hydrogel treated). This transient increase in IOP may be correlated with the presence of infection due to the influx of inflammatory material that compromise the blood-ocular barrier 39. After 12 hours, all animals that received VAN loaded DDS treatment were measured to have an IOP values that returned to the preinjection values, indicating that subconjunctival injection of our VAN DDS had minimal impact on rat IOP.…”

Section: Discussionmentioning

confidence: 97%

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

Dosmar

Liu

Patel

et al. 2019

Trans. Vis. Sci. Tech.

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Section: Discussionmentioning

confidence: 97%

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

Dosmar

Liu

Patel

et al. 2019

Trans. Vis. Sci. Tech.

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“…One recent study reported that H . pylori seropositivity was associated with elevated IOP in anterior uveitis [ 22 ]. In our study, H .…”

Section: Discussionmentioning

confidence: 99%

The Rate of Helicobacter pylori Seropositivity in a Group of Korean Patients with HLA-B27-Associated Acute Anterior Uveitis

Bae

Kim

2015

PLoS ONE

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PurposeTo investigate an association between Helicobacter pylori seropositivity and HLA-B27-positive acute anterior uveitis (AAU) in Korean patients.MethodsRetrospective analysis was performed with data from 106 patients previously diagnosed with AAU without clinical evidence of spondyloarthropathy. Serum immunoglobulin G antibodies to H. pylori were measured by enzyme-linked immunosorbent assay, and HLA typing was performed using polymerase chain reaction of DNA amplification. We included 72 non-uveitis patients and 35 age- and sex-matched healthy controls in the study.ResultsOf the 106 patients with AAU, 41 (38.7%) were HLA-B27-positive, and 45 (42.5%) were seropositive for H. pylori. Patients with HLA-B27-positive AAU had a significantly lower prevalence of H. pylori seropositivity compared to those with HLA-B27-negative AAU and healthy controls (24.4% vs. 53.8%, p = 0.003; 24.4% vs. 57.1%, p = 0.004, respectively). In the non-uveitis group, however, HLA-B27-positive patients exhibited similar H. pylori seropositivity prevalence to HLA-B27-negative patients and healthy controls (45.5% vs. 55.7%, p = 0.529; 45.5% vs. 57.1%, p = 0.497, respectively). In multivariate analysis, a low prevalence of H. pylori seropositivity was significantly associated with HLA-B27-positive AAU (odds ratio = 0.340, 95% confidence interval 0.135–0.855, p = 0.022).ConclusionsOur results suggest an inverse association between H. pylori seropositivity and HLA-B27-positive AAU. Further investigation of this association is needed, given the low prevalence of H. pylori seropositivity observed in patients with HLA-B27-positive AAU.

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“…Unfortunately, the sample examined was too small to allow for any concrete conclusions. Kim et al 171 have detected on a sample of 165 subjects that Hp infection is associated with high IOP in anterior uveitis, but without finding a real causal connection between Hp infection and ocular hypertension. Thus, uveitis involved in a multitude of diseases; many chronic inflammatory diseases are associated with an elevated risk of uveitis, eg, rheumatoid arthritis, ankylosing spondylitis, 172 Behcet disease, 173 and Crohn disease.…”

Section: Methodsmentioning

confidence: 99%

Helicobacter pylori Infection and Eye Diseases

et al. 2014

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The connection between Helicobacter pylori (Hp) infection and eye diseases has been increasingly reported in the literature and in active research. The implication of this bacterium in chronic eye diseases, such as blepharitis, glaucoma, central serous chorioretinopathy and others, has been hypothesized. Although the mechanisms by which this association occurs are currently unknown, this review describes shared pathogenetic mechanisms in an attempt to identify a lowest common denominator between eye diseases and Hp infection.The aim of this review is to assess whether different studies could be compared and to establish whether or not Hp infection and Eye diseases share common pathogenetic aspects. In particular, it has been focused on oxidative damage as a possible link between these pathologies.Text word search in Medline from 1998 to July 2014.152 studies were included in our review.Were taken into considerations only studies that related eye diseases more frequent and/or known.Likely oxidative stress plays a key role. All of the diseases studied seem to follow a common pattern that implicates a cellular response correlated with a sublethal dose of oxidative stress. These alterations seem to be shared by both Hp infections and ocular diseases and include the following: decline in mitochondrial function, increases in the rate of reactive oxygen species production, accumulation of mitochondrial DNA mutations, increases in the levels of oxidative damage to DNA, proteins and lipids, and decreases in the capacity to degrade oxidatively damaged proteins and other macromolecules. This cascade of events appears to repeat itself in different diseases, regardless of the identity of the affected tissue. The trabecular meshwork, conjunctiva, and retina can each show how oxidative stress may acts as a common disease effector as the Helicobacter infection spreads, supported by the increased oxidative damage and other inflammation.

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The effects of Helicobacter pylori infection on intraocular pressure in anterior uveitis

Cited by 7 publications

References 38 publications

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

The Rate of Helicobacter pylori Seropositivity in a Group of Korean Patients with HLA-B27-Associated Acute Anterior Uveitis

Helicobacter pylori Infection and Eye Diseases

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