The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Farsimadan, Marziye; Riahi, Seyed Mohammad; Muhammad, Huda Muhaddien; Emamvirdizadeh, Alireza; Tabasi, Mohsen; Motamedifar, Mohammad; Roviello, Giandomenico

doi:10.1111/jvh.13565

Cited by 19 publications

(17 citation statements)

References 57 publications

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“…Previous studies have found no link between maternal HBV infection and live birth, preterm birth, or pregnancy rates in women undergoing assisted reproductive technology . Our study confirms that maternal HBV serostatus is not associated with pregnancy outcomes in infertile women undergoing FET.…”

Section: Discussionsupporting

confidence: 79%

Maternal Hepatitis B Virus Infection and Pregnancy Outcomes of Freeze-Thaw Embryo Transfer

et al. 2023

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Section: Discussionsupporting

confidence: 79%

Maternal Hepatitis B Virus Infection and Pregnancy Outcomes of Freeze-Thaw Embryo Transfer

et al. 2023

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“…Previous population studies 12,13,[37][38][39][40] on the association of HBV infection with fecundability have shown inconsistent results. Studies 12,37 of women found that HBV-infected persons undergoing assisted reproduction procedures had prolonged durations of infertility.…”

Section: Jama Network Open | Obstetrics and Gynecologymentioning

confidence: 99%

Assessment of Prior Infection With Hepatitis B Virus and Fecundability in Couples Planning Pregnancy

Zhao,

Xuan,

Zhang

et al. 2023

JAMA Netw Open

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IMPORTANCEThe association of hepatitis B virus (HBV) infection with reduced fecundability among reproductive-aged couples lacks large-population, in-depth study evidence.OBJECTIVETo investigate the association of HBV infection with time to pregnancy in couples planning pregnancy, and to explore whether this association varied by gravidity, health statuses, or lifestyles.DESIGN, SETTING, AND PARTICIPANTSThis is a population-based cohort study of Chinese couples participating in the National Free Preconception Check-up Projects during 2015 to 2017. They were planning pregnancy and were followed-up every 3 months until getting pregnant, as confirmed by gynecologic ultrasonography, or were followed-up for 1 year. Data were analyzed between March 1, 2022, and September 30, 2022.MAIN OUTCOMES AND MEASURESThe main outcome was time to pregnancy, assessed using fecundability hazard ratios (HRs). The Cox proportional hazards regression models were used to estimate the association of HBV infection with fecundability.RESULTSAmong 2 419 848 couples (mean [SD] age, 27.87 [5.20] years for women and 29.58 [5.50] years for men), 126 728 women (5.24%) and 156 572 men (6.47%) were infected with HBV. Compared with the HBV-negative group, the fecundability of both women and men in the HBV-positive group decreased by 5% (HR, 0.95; 95% CI, 0.94-0.95). Compared with couples in which both partners were HBV negative, the fecundability of those in which both partners were HBV positive declined by 6% (HR, 0.94; 95% CI, 0.93-0.96) among all couples, by 3% (HR, 0.97; 95% CI, 0.95-0.99) among nulligravidas couples, and by 7% (HR, 0.93; 95% CI, 0.91-0.95) among multigravidas couples. Both the female-male and couple models suggested that the association of HBV infection with decreased fecundability was more pronounced in couples with multigravidas. The negative association was greater in people with overweight and obesity and was inconsistent in certain subgroups; in particular, it was more pronounced in women with reproductive tract infections, normal fasting plasma glucose, and no alcohol intake and in men with normal blood pressure.CONCLUSIONS AND RELEVANCEIn this population-based cohort study, HBV infection was associated with decreased fecundability in a general reproductive-aged population, especially in couples with multigravidas. For women and men with certain health statuses and lifestyles, a comprehensive consideration of this association is recommended to provide personalized fertility guidance.

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“…Male factors constitute 40 to 50% of all infertility cases [ 5 ]. Pathological agents, especially viruses, play a distinctive role in infertility [ 6 , 7 ]. Viruses as a major cause of fertility problems are able to potentially interfere with reproductive function in men [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 effects on sperm parameters: a meta-analysis study

Xie

Mirzaei

Kahrizi

et al. 2022

J Assist Reprod Genet

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Aim The rapid outbreak of the coronavirus disease 2019 (COVID-19) pandemic posed challenges across different medical fields, especially reproductive health, and gave rise to concerns regarding the effects of SARS-CoV-2 on male infertility, owing to the fact that the male reproductive system indicated to be extremely vulnerable to SARS-CoV-2 infection. Only a small number of studies have investigated the effects of SARS-CoV-2 on male reproduction, but the results are not consistent. So, we performed this meta-analysis to draw a clearer picture and evaluate the impacts of COVID-19 on male reproductive system. Method We searched Embase, Web of Science, PubMed, and Google Scholar databases to identify the potentially relevant studies. Standardized mean difference (SMD) with 95% confidence interval (CI) was applied to assess the relationship. Heterogeneity testing, sensitivity analysis, and publication bias testing were also performed. Results A total of twelve studies including 7 case control investigations and 5 retrospective cohort studies were found relevant and chosen for our research. Our result showed that different sperm parameters including semen volume [SMD = − 0.27 (− 0.46, − 1.48) ( p = 0.00)], sperm concentration [SMD = − 0.41 (− 0.67, − 0.15) ( p = 0.002)], sperm count [SMD = − 0.30 (− 0.44, − 0.17) ( p = 0.00)], sperm motility [SMD = − 0.66 (− 0.98, − 0.33) ( p = 0.00)], and progressive motility [SMD = − 0.35 (− 0.61, − 0.08) ( p = 0.01)] were negatively influenced by SARS-CoV-2 infection. However, sperm concentration ( p = 0.07) and progressive motility ( p = 0.61) were not found to be significantly associated with SARS-CoV-2 infection in case control studies. No publication bias was detected. Conclusion The present study revealed the vulnerability of semen quality to SARS-CoV-2 infection. Our data showed a strong association of different sperm parameters with SARS-CoV-2 infection. The results suggested that SARS-CoV-2 infection in patients may negatively influence their fertility potential in a short-term period, but more studies are needed to decide about the long-term effects.

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The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta‐analysis study

Cited by 19 publications

References 57 publications

Maternal Hepatitis B Virus Infection and Pregnancy Outcomes of Freeze-Thaw Embryo Transfer

Maternal Hepatitis B Virus Infection and Pregnancy Outcomes of Freeze-Thaw Embryo Transfer

Assessment of Prior Infection With Hepatitis B Virus and Fecundability in Couples Planning Pregnancy

SARS-CoV-2 effects on sperm parameters: a meta-analysis study

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