The Effects of High Altitude Trekking on Body Composition and Resting Metabolic Rate

Armellini, F; Zamboni, Mauro; Robbi, R; Todesco, Tiziana; Bissoli, Luisa; Mino, Antonietta; Angelini, G; Micciolo, Rocco; Bosello, O

doi:10.1055/s-2007-979077

Cited by 43 publications

(42 citation statements)

References 8 publications

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“…In this study, body weight, Lee's index, fat mass, and the fat mass to body weight ratio in the H group rats were all significantly lower than those in the N group, which was consistent with previous studies (Armellini et al, 1997;Netzer et al, 2008;Lippl et al, 2010). Armellini et al (1997) thought that the reduction in energy intake may contribute to weight loss in individuals undergoing high altitude training.…”

Section: Discussionsupporting

confidence: 92%

“…Armellini et al (1997) thought that the reduction in energy intake may contribute to weight loss in individuals undergoing high altitude training. Lippl et al (2010) found that the body weight of obese men was significantly lower at a 2650 m altitude for 7 d, which may be due to a significantly higher resting metabolic rate and leptin level.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have indicated that sea level residents lost body weight during their acute exposure to highaltitude hypoxia (Ge et al, 2010), which induced a weight loss due approximately 2/3rds to fat loss and 1/3rd to lean mass loss (Armellini et al, 1997). Mild physical exercise in normobaric hypoxia for eight weeks led to a significantly greater weight loss in obese persons than exercise in sham hypoxia (Netzer et al, 2008).…”

Section: Introductionmentioning

confidence: 94%

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Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers

Wen

Feng

et al. 2014

J. Zhejiang Univ. Sci. B

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Abstract:To investigate the effects of hypoxic exercise training on microRNA (miRNA) expression and the role of miRNA expression in regulating lipid metabolism, 20 dietary-induced obese SD rats were divided into a normoxic sedentary group (N, n=10) and a hypoxic exercise training group (H, n=10). After four weeks, measurements were taken of body weight, body length, fat mass, serum lipid concentration, miRNAs differentially expressed in rat liver, and gene and protein expression levels of peroxisome proliferator activated receptor α (PPARα), fatty acid synthetase (FAS), and carnitine palmitoyl transferase 1A (CPT1A) in rat liver. Body weight, Lee's index, fat mass, fat/weight ratio, and serum levels of total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were all significantly lower in the H group than in the N group (P<0.01). Six miRNAs expressed significantly differently in the liver (P<0.05). Specifically, expression levels of miR-378b were significantly lower in the H group than in the N group (P<0.05). Compared with the normoxic sedentary group, hypoxic exercise training resulted in a lower ratio of FAS mRNA to CPT1A mRNA (P<0.05), as well as lower CPT1A protein levels (P<0.01), while a higher ratio of FAS to CPT1A protein levels (P<0.01) was observed. In conclusion, hypoxic training may elevate the resistance of high fat diet induced obesity in rats by reducing the expression of miR-378b, and decrease the fatty acid mitochondrial oxidation in obese rat livers by decreasing the protein expression of CPT1A and increasing the protein expression ratio of FAS/CPT1A.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers

Wen

Feng

et al. 2014

J. Zhejiang Univ. Sci. B

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“…It is interesting, that the authors also mention possible health benefits of longterm work in hypoxic conditions as some recent papers about hypoxia training indicate (e.g. Boyer and Blume, 1984;Rose et al, 1988;Kayser, 1992Kayser, , 1994Armellini et al, 1997;Schobersberger et al, 2003;Haufe et al, 2008;Netzer et al, 2008).…”

Section: Problems With Present Guidancementioning

confidence: 99%

“…The whole discussion is dominated by (fictive) risk assumptions, while some data suggest that intermittent hypoxia of moderate degree also has some benefit instead of risk for persons who are regular exposed as there are an amelioration of the lipid profile, insulin resistance, leptin, body weight, and others (e.g. Boyer and Blume, 1984;Azevedo 378 T. Küpper et al et al, 1995;Armellini et al, 1997;Grosfeld et al, 2002;Schobersberger et al, 2003;Simler et al, 2006;Yingzhong et al, 2006;Netzer et al, 2008). In conclusion, a more detailed specialized analysis of the individual exposure is necessary to provide adequate advice for health and safety.…”

Section: Problems With Present Guidancementioning

confidence: 99%

Work in Hypoxic Conditions-Consensus Statement of the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom)

Küpper

Milledge

Hillebrandt³

et al. 2011

The Annals of Occupational Hygiene

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Objectives: The Commission gives recommendations on how to provide health and safety for employees in different kinds of low oxygen atmospheres. So far, no recommendations exist that take into account the several factors we have outlined in this report.Methods: The health and safety recommendations of several countries were analysed for their strength and deficiencies. The scientific literature was checked (Medline, etc.) and evaluated for relevance of the topic. Typical situations of work in hypoxia were defined and their specific risks described. Specific recommendations are provided for any of these situations.Results: We defined four main groups with some subgroups (main risk in brackets): short exposure (pressure change), limited exposure (acute altitude disease), expatriates (chronic altitude disease), and high-altitude populations (re-entry pulmonary oedema). For healthy unacclimatized persons, an acute but limited exposure down to 13% O 2 does not cause a health risk. Employees should be advised to leave hypoxic areas for any break, if possible. Detailed advice is given for any other situation and pre-existing diseases.Conclusions: If the specific risk of the respective type of hypoxia is taken into account, a pragmatic approach to provide health and safety for employees is possible. In contrast to other occupational exposures, a repeated exposure as often as possible is of benefit as it causes partial acclimatization. The consensus statement was approved by written consent in lieu of a meeting in July 2009.

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The predictive equations of resting metabolic rate for Tibetan adolescents aged 13–18 in Tibet, China

Sun

Liu

Yin

et al. 2022

American J Hum Biol

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Objectives The resting metabolic rate (RMR) predictive equations suitable for Tibetan adolescents in Tibet, China, were developed to provide a reference for their reasonable energy intake. Methods We measured RMR by indirect calorimetry and body composition by bioelectrical impedance analysis in 325 Tibetan adolescents aged 13–18 years in Tibet, China. Stepwise regression analysis was used to develop the predictive equations. Pearson correlation analysis, paired sample t test, bias rate, concordance correlation coefficient (CCC) and Bland–Altman were used to verify the validity of the predictive equations. Results The R2 of Model 8 (0.642) was larger than Model 2 (boys, 0.642; girls, 0.533) and Model 7 (0.540), and Model 10 (0.534) was larger than Model 4 (boys, 0.531; girls, 0.443) and Model 9 (0.477).Compared with the existing predictive equations, the correlation (0.68–0.84) between the predicted values and the measured values, CCC (0.74–0.81) and consistency (Similar proportions within the upper and lower limits but lower differences) were higher and the bias rate (−1.0% to −2.5%) and root mean square error (207.4–263.7 kcal/day) were lower in this study. By comprehensive comparison, Model 8 and Model 10 were more valid. Conclusions The existing predictive equations cannot accurately predict the RMR of Tibetan adolescents in Tibet, China. In this study, the age segmentation predictive equations with age, sex, and fat free mass (FFM) as independent variables were more valid. The predictive equations were as follows: RMR (kcal/day) = 50.1 × FFM (kg) − 202.8 × Sex (F: 0; M: 1) − 72.1 × Age + 930.3, 13–15 years; RMR (kcal/day) = 58.4 × FFM (kg) − 441.1 × Sex (F: 0; M: 1) − 702.2, 16–18 years.

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The Effects of High Altitude Trekking on Body Composition and Resting Metabolic Rate

Cited by 43 publications

References 8 publications

Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers

Effects of hypoxic exercise training on microRNA expression and lipid metabolism in obese rat livers

Work in Hypoxic Conditions-Consensus Statement of the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom)

The predictive equations of resting metabolic rate for Tibetan adolescents aged 13–18 in Tibet, China

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