The Effects of High Lighting on the Development of Form-Deprivation Myopia in Guinea Pigs

Zhang, Luoli; Qu, Xiaomei

doi:10.1167/iovs.18-25258

Cited by 21 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After that, it was possible to discover that children spending more time outdoors and exposed to increased light have not only a lower prevalence of myopia but also lower myopic changes in both nonmyopic and myopic children [130][131][132][133][134][135][136]. The effect of ambient light in myopia control has been confirmed in animal studies, where it was found that the presence of dopamine plays an important role in reducing myopia progression [129,[137][138][139]. It should be considered that dopamine and melatonin circadian cycles oscillate in antiphase in the central nervous system [140], including the retina [141].…”

Section: Myopiamentioning

confidence: 90%

Influence of Circadian Rhythm in the Eye: Significance of Melatonin in Glaucoma

et al. 2021

View full text Add to dashboard Cite

Circadian rhythm and the molecules involved in it, such as melanopsin and melatonin, play an important role in the eye to regulate the homeostasis and even to treat some ocular conditions. As a result, many ocular pathologies like dry eye, corneal wound healing, cataracts, myopia, retinal diseases, and glaucoma are affected by this cycle. This review will summarize the current scientific literature about the influence of circadian patterns on the eye, focusing on its relationship with increased intraocular pressure (IOP) fluctuations and glaucoma. Regarding treatments, two ways should be studied: the first one, to analyze if some treatments could improve their effect on the ocular disease when their posology is established in function of circadian patterns, and the second one, to evaluate new drugs to treat eye pathologies related to the circadian rhythm, as it has been stated with melatonin or its analogs, that not only could be used as the main treatment but as coadjutant, improving the circadian pattern or its antioxidant and antiangiogenic properties.

show abstract

Section: Myopiamentioning

confidence: 90%

Influence of Circadian Rhythm in the Eye: Significance of Melatonin in Glaucoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…21 In the current experiments, we first investigated the levels of correlation of ChBP with myopia development and scleral hypoxia, in various experimental settings, including those with antimyopia treatments such as the administration of atropine, 29 apomorphine, 26 and the exposure to intense light. 30 We then explored the impact of increasing ChBP on the development of myopia, by administering the vasodilator prazosin in the form-deprivation guinea pig eyes.…”

mentioning

confidence: 99%

Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs

Zhou

Zhang

et al. 2020

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

In guinea pigs, choroidal thickness (ChT) and choroidal blood perfusion (ChBP) simultaneously decrease in experimental myopia, and both increase during recovery. However, the causal relationship between ChBP and myopia requires further investigation. In this study, we examined the changes of ChBP with three different antimyopia treatments. We also actively increased ChBP to examine the direct effect on myopia development in guinea pigs. METHODS. Experiment 1: Guinea pigs wore occluders on the right eye for two weeks to induce form-deprivation myopia (FDM). Simultaneously they received daily antimyopia treatments: peribulbar injections of atropine or apomorphine or exposure to intense light. Experiment 2: The vasodilator prazosin was injected daily into the form-deprivation eyes to increase ChBP during the two-week induction of FDM. Other FDM animals received appropriate control treatments. Changes in refraction, axial length, ChBP, ChT, and hypoxia-labeled pimonidazole adducts in the sclera were measured. RESULTS. The antimyopia treatments atropine, apomorphine, and intense light all significantly inhibited myopia development and the decrease in ChBP. The treatments also reduced scleral hypoxia, as indicated by the decrease in hypoxic signals. Furthermore, actively increasing ChBP with prazosin inhibited the progression of myopia, as well as the increase in axial length and scleral hypoxia. CONCLUSIONS. Our data strongly indicate that increased ChBP attenuates scleral hypoxia, and thereby inhibits the development of myopia. Thus ChBP may be a promising target for myopia retardation. As such, it can serve as an immediate predictor of myopia development as well as a long-term marker of it.

show abstract

“…107 In guinea pigs, bright light (10,000 lux) reduced the myopic shift induced by form deprivation compared with normal lighting (500 lux). 108 While in mice, bright light exposure (2500–5000 lux) for 6 h/day for 4 weeks prevented FDM and presented a hyperopic shift and reduction in ocular elongation compared with normal lighting (100–200 lux). 105 Analogously to bright light, albeit through different mechanisms, short periods (~3 h/day) of de-focusing lens removal or normal vision per day, even in moderate light levels, can compensate for LIM in chickens.…”

Section: Experimental Research On Light and Myopiamentioning

confidence: 96%

Light and myopia: from epidemiological studies to neurobiological mechanisms

et al. 2021

View full text Add to dashboard Cite

Myopia is far beyond its inconvenience and represents a true, highly prevalent, sight-threatening ocular condition, especially in Asia. Without adequate interventions, the current epidemic of myopia is projected to affect 50% of the world population by 2050, becoming the leading cause of irreversible blindness. Although blurred vision, the predominant symptom of myopia, can be improved by contact lenses, glasses or refractive surgery, corrected myopia, particularly high myopia, still carries the risk of secondary blinding complications such as glaucoma, myopic maculopathy and retinal detachment, prompting the need for prevention. Epidemiological studies have reported an association between outdoor time and myopia prevention in children. The protective effect of time spent outdoors could be due to the unique characteristics (intensity, spectral distribution, temporal pattern, etc.) of sunlight that are lacking in artificial lighting. Concomitantly, studies in animal models have highlighted the efficacy of light and its components in delaying or even stopping the development of myopia and endeavoured to elucidate possible mechanisms involved in this process. In this narrative review, we (1) summarize the current knowledge concerning light modulation of ocular growth and refractive error development based on studies in human and animal models, (2) summarize potential neurobiological mechanisms involved in the effects of light on ocular growth and emmetropization and (3) highlight a potential pathway for the translational development of noninvasive light-therapy strategies for myopia prevention in children.

show abstract

The Effects of High Lighting on the Development of Form-Deprivation Myopia in Guinea Pigs

Cited by 21 publications

References 39 publications

Influence of Circadian Rhythm in the Eye: Significance of Melatonin in Glaucoma

Influence of Circadian Rhythm in the Eye: Significance of Melatonin in Glaucoma

Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs

Light and myopia: from epidemiological studies to neurobiological mechanisms

Contact Info

Product

Resources

About