The effects of Hippophae rhamnoides in neuroprotection and behavioral alterations against iron-induced epilepsy

Ladol, Stanzin; Sharma, Deepak

doi:10.1016/j.eplepsyres.2021.106695

Cited by 8 publications

(4 citation statements)

References 52 publications

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“…The fraction had also some anti-apoptotic properties (Cho et al 2017 ). SB fruit juice, administered to Wistar rats with induced epilepsy (at the dose of 1 mL kg −1 b.w., for 1 month), significantly reduced the epileptiform activity, improved abnormalities of behaviour, and improved histological structure of cortex and hippocampus (Ladol and Sharma 2021 ).…”

Section: Pharmacologymentioning

confidence: 99%

Phytochemistry and pharmacology of sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides): progress from 2010 to 2021

Żuchowski

2022

Phytochem Rev

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Sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides) is a thorny shrub or a small tree belonging to the Elaeagnaceae family, native to Eurasia. Sea buckthorn fruit is rich in vitamins and minerals, oils from the seeds and fruit flesh find use in medicine and the cosmetic industry or as nutraceutical supplements. Fruit, leaves and other parts of buckthorn have been used in traditional medicine, especially in China, Tibet, Mongolia, and Central Asia countries, and are a rich source of many bioactive substances. Due to its health-promoting and medicinal properties, the plant has been extensively investigated for several decades, and its phytochemical composition and pharmacological properties are well characterized. The years 2010–2021 brought significant progress in phytochemical research on sea buckthorn. Dozens of new compounds, mainly phenolics, were isolated from this plant. Numerous pharmacological studies were also performed, investigating diverse aspects of the biological activity of different extracts and natural products from sea buckthorn. This review focuses on the progress in research on sea buckthorn specialized metabolites made in this period. Pharmacological studies on sea buckthorn are also discussed. In addition, biosynthetic pathways of the main groups of these compounds have been shortly described. Graphical abstract

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Section: Pharmacologymentioning

confidence: 99%

Phytochemistry and pharmacology of sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides): progress from 2010 to 2021

Żuchowski

2022

Phytochem Rev

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“…After nanoscale intracortical iron injection (100 mM, 350 nL), the number of γ-aminobutyrate (GABA)ergic interneurons in the injected hemisphere decreases, and chronic epilepsy develops [60]. After local injection of cortical ferric chloride (100 mM, 5 µL) in rats, seizurs and epileptic discharges can be observed via electroencephalography [61]. These effects occur because free radicals generated by iron attack cell membranes through lipid peroxidation, diminishing nitric oxide synthase (NOS) activity, leading to neuronal damage and eventually to epileptic seizures [62].…”

Section: Iron Metabolism Abnormalities In Epilepsymentioning

confidence: 99%

Insight into the Role of Ferroptosis in Epilepsy

Huang,

Liu,

Liu

2024

J. Integr. Neurosci.

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Excessively high or synchronized neuronal activity in the brain is the underlying cause of epilepsy, a condition of the central nervous system. Epilepsy is caused mostly by an imbalance in the activity of inhibitory and excitatory neural networks. Recurrent or prolonged seizures lead to neuronal death, which in turn promotes epileptogenesis and epileptic seizures. Ferrous ion-mediated cell death is known as ferroptosis, which is due to the accumulation of lipid peroxidation products resulting from compromise of the glutathione (GSH)-dependent antioxidant system. The pathophysiology of epilepsy has been linked to anomalies in the glutathione peroxidase 4 (GPX4)/GSH redox pathway, lipid peroxidation, and iron metabolism. Studies have shown that inhibiting ferroptosis may alleviate cognitive impairment and decrease seizures, indicating that it is neuroprotective. With the hope of aiding the development of more novel approaches for the management of epilepsy, this research aimed to examine the role of ferroptosis in this disease.

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“…It inhibited insulin resistance and neuroinflammation, attenuated HFD-induced cognitive impairment, and effectively prevented memory loss ( 80 ). In addition, sea buckthorn improved epileptiform activity in the cerebral cortex and hippocampus in iron-induced epilepsy rats and reduced anxiety-like behavior, and improved memory impairment and histological damage in rats ( 87 ). In conclusion, sea buckthorn has been demonstrated to possess neuroprotective effects.…”

Section: Health Benefitsmentioning

confidence: 99%

Phytochemistry, health benefits, and food applications of sea buckthorn (Hippophae rhamnoides L.): A comprehensive review

et al. 2022

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Sea buckthorn (Hippophae rhamnoides L.), an ancient miraculous plant, is of great interest because of its tenacity, richness in nutritional active substances, and biological activity. Sea buckthorn is a deciduous shrub or tree of the genus Hippophae in the family Elaeagnaceae. It is a pioneer tree species for soil improvement, wind and sand control, and soil and water conservation. Sea buckthorn contains many nutritional active components, such as vitamins, carotenoids, polyphenols, fatty acids, and phytosterols. Moreover, sea buckthorn has many health benefits, such as antioxidant, anticancer, anti-hyperlipidemic, anti-obesity, anti-inflammatory, antimicrobial, antiviral, dermatological, neuroprotective, and hepatoprotective activities. Sea buckthorn not only has great medicinal and therapeutic potential, but also is a promising economic plant. The potential of sea buckthorn in the human food industry has attracted the research interest of researchers and producers. The present review mainly summarizes the phytochemistry, nutrients, health benefits, and food applications of sea buckthorn. Overall, sea buckthorn is a dietary source of bioactive ingredients with the potential to be developed into functional foods or dietary supplements for the prevention and treatment of certain chronic diseases, which deserves further research.

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The effects of Hippophae rhamnoides in neuroprotection and behavioral alterations against iron-induced epilepsy

Cited by 8 publications

References 52 publications

Phytochemistry and pharmacology of sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides): progress from 2010 to 2021

Phytochemistry and pharmacology of sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides): progress from 2010 to 2021

Insight into the Role of Ferroptosis in Epilepsy

Phytochemistry, health benefits, and food applications of sea buckthorn (Hippophae rhamnoides L.): A comprehensive review

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