The effects of histamine H2 receptor antagonists on melanogenesis and cellular proliferation in melanoma cells in culture

Phenotypic Profiling of Engineered Mouse Melanomas with Manipulated Histamine Production Identifies Histamine H2 Receptor and Rho-C as Histamine-Regulated Melanoma Progression Markers

“…9-11); however, the actual impact of histamine-controlled signaling loops on melanoma progression is not yet fully understood. Although histaminemediated signals have been shown to be implicated in tumor growth (12)(13)(14)(15)(16)(17), local (18)(19)(20), and systemic immunomodulation (21), a detailed unifying concept explaining the actual importance of this phenomenon is still unavailable. Finally, it should be noted that enhanced histidine catabolism in tumors is not a unique phenomenon, in as much as similar perturbations in the metabolism of several amino acids, such as massive degradation of tryptophan by the indoleamine 2,3-dioxygenase (22), or enhanced hydrolysis of arginine by arginase (23), have already been associated with the process of tumor progression.…”

Skin reactivity to histamine and expression of histamine receptors mRNA in lymphocytes of healthy subjects and non-small-cell lung cancer patients before and after surgery

“…This receptor participates also in enhancing response to an antigen by T lymphocytes [5][6][7][8]. Through H2R, histamine plays the immunoregulatory role, inhibiting numerous immunological processes [9][10][11][12]38], increasing proliferation of cells [39][40][41][42][43] and inducing protooncogene c-fas [44].…”

Histamine Receptors as Potential Therapeutic Targets for Cancer Drug Development

“…cimetidine, famotidine, roxatidine) inhibited this effect Szincsák et al, 2002;Uçar, 1991). Additionally, H 2 R antagonists stimulated melanogenesis and inhibited proliferation in B16-C3 mouse melanoma cells (Uçar, 1991). It was also found that melanoma tumour growth was not modulated by in vivo histamine treatment while treatment with terfenadine, an H 1 R antagonist, in vitro induced melanoma cell death by apoptosis and in vivo significantly inhibited tumour growth in murine models (Blaya et al, 2010).…”

“…Numerous in vivo studies employing animal models bearing syngenic or xenogenic melanoma grafts demonstrated that both endogenous and exogenous histamine have the ability to stimulate tumour growth while H 2 R antagonists (e.g. cimetidine, famotidine, roxatidine) inhibited this effect Szincsák et al, 2002;Uçar, 1991). Additionally, H 2 R antagonists stimulated melanogenesis and inhibited proliferation in B16-C3 mouse melanoma cells (Uçar, 1991).…”