The effects of histone deacetylase inhibitors on the attentional set-shifting task performance of alcohol-dependent rats

Zhang, Xianqiang; Sun, Lin; Wang, Li; Wang, Mengting; Li, Guohua; Wang, Yanyu; Li, Qi; Li, Changjiang; Zhou, Jin; Ma, Huimin; Sun, Hongwei

doi:10.1016/j.brainresbull.2019.04.020

Cited by 2 publications

(2 citation statements)

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“…Differences here may be due to slightly shorter exposure time and the lower intake levels in the volitional drinking phases. That said, rats that were trained to self-administer alcohol over 28 days, achieving intake rates of 0.5–0.8 g/kg/h, showed deficits in odor and texture-based set-shifting, with increased number of trials required to complete the task and a higher error rate ( Zhang et al, 2019 ). Although intake levels were smaller, an important difference here is that the subjects (in this case rats) had to learn to perform a specific response to obtain alcohol.…”

Section: Methods Of Administrationmentioning

confidence: 99%

The Effect of Chronic Alcohol on Cognitive Decline: Do Variations in Methodology Impact Study Outcome? An Overview of Research From the Past 5 Years

Charlton

Perry

2022

Front. Neurosci.

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Excessive alcohol use is often associated with accelerated cognitive decline, and extensive research using animal models of human alcohol consumption has been conducted into potential mechanisms for this relationship. Within this literature there is considerable variability in the types of models used. For example, alcohol administration style (voluntary/forced), length and schedule of exposure and abstinence period are often substantially different between studies. In this review, we evaluate recent research into alcohol-induced cognitive decline according to methodology of alcohol access, as well as cognitive behavioral task employed. Our aim was to query whether the nature and severity of deficits observed may be impacted by the schedule and type of alcohol administration. We furthermore examined whether there is any apparent relationship between the amount of alcohol consumed and the severity of the deficit, as well as the potential impact of abstinence length, and other factors such as age of administration, and sex of subject. Over the past five years, researchers have overwhelmingly used non-voluntary methods of intake, however deficits are still found where intake is voluntary. Magnitude of intake and type of task seem most closely related to the likelihood of producing a deficit, however even this did not follow a consistent pattern. We highlight the importance of using systematic and clear reporting styles to facilitate consistency across the literature in this regard. We hope that this analysis will provide important insights into how experimental protocols might influence findings, and how different patterns of consumption are more or less likely to produce an addiction-vulnerable cognitive phenotype in animal models.

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Section: Methods Of Administrationmentioning

confidence: 99%

The Effect of Chronic Alcohol on Cognitive Decline: Do Variations in Methodology Impact Study Outcome? An Overview of Research From the Past 5 Years

Charlton

Perry

2022

Front. Neurosci.

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“…Preclinical test results indicate the potential for using HDACis to treat drug addiction [192][193][194][195][196][197]. However, an increase in the dependence rate upon administration of HDACis was also noted, which can result from the interaction of the epidrug activity and the phase of addiction development [198].…”

Section: Drug Addictionmentioning

confidence: 99%

Epidrugs in the Therapy of Central Nervous System Disorders: A Way to Drive on?

Гладкова

Leidmaa

Anderzhanova

2023

Cells

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The polygenic nature of neurological and psychiatric syndromes and the significant impact of environmental factors on the underlying developmental, homeostatic, and neuroplastic mechanisms suggest that an efficient therapy for these disorders should be a complex one. Pharmacological interventions with drugs selectively influencing the epigenetic landscape (epidrugs) allow one to hit multiple targets, therefore, assumably addressing a wide spectrum of genetic and environmental mechanisms of central nervous system (CNS) disorders. The aim of this review is to understand what fundamental pathological mechanisms would be optimal to target with epidrugs in the treatment of neurological or psychiatric complications. To date, the use of histone deacetylases and DNA methyltransferase inhibitors (HDACis and DNMTis) in the clinic is focused on the treatment of neoplasms (mainly of a glial origin) and is based on the cytostatic and cytotoxic actions of these compounds. Preclinical data show that besides this activity, inhibitors of histone deacetylases, DNA methyltransferases, bromodomains, and ten-eleven translocation (TET) proteins impact the expression of neuroimmune inflammation mediators (cytokines and pro-apoptotic factors), neurotrophins (brain-derived neurotropic factor (BDNF) and nerve growth factor (NGF)), ion channels, ionotropic receptors, as well as pathoproteins (β-amyloid, tau protein, and α-synuclein). Based on this profile of activities, epidrugs may be favorable as a treatment for neurodegenerative diseases. For the treatment of neurodevelopmental disorders, drug addiction, as well as anxiety disorders, depression, schizophrenia, and epilepsy, contemporary epidrugs still require further development concerning a tuning of pharmacological effects, reduction in toxicity, and development of efficient treatment protocols. A promising strategy to further clarify the potential targets of epidrugs as therapeutic means to cure neurological and psychiatric syndromes is the profiling of the epigenetic mechanisms, which have evolved upon actions of complex physiological lifestyle factors, such as diet and physical exercise, and which are effective in the management of neurodegenerative diseases and dementia.

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The effects of histone deacetylase inhibitors on the attentional set-shifting task performance of alcohol-dependent rats

Cited by 2 publications

References 54 publications

The Effect of Chronic Alcohol on Cognitive Decline: Do Variations in Methodology Impact Study Outcome? An Overview of Research From the Past 5 Years

The Effect of Chronic Alcohol on Cognitive Decline: Do Variations in Methodology Impact Study Outcome? An Overview of Research From the Past 5 Years

Epidrugs in the Therapy of Central Nervous System Disorders: A Way to Drive on?

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