The effects of hydrocephalus on the periventricular white matter in intracerebral hemorrhage: a diffuser tensor imaging study

Jang, Sung Ho; Choi, Byung Yeon; Chang, Chul Hoon; Jung, Young‐Dae; Byun, Woo Mok; Kim, Seong Ho; Yeo, Sang Seok

doi:10.3109/00207454.2012.763164

Cited by 23 publications

(30 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The FA value is closely related to the myelin integrity, nerve fiber density, and orientation. [10,23,24] In this study, we found that the FA values of ROIs before the ventriculoperitoneal shunt were substantially lower in the patients than the control group, which might reflect the demyelination of the white matter caused by enlarged ventricles and high intracranial pressure. [25,26] The FA values significantly increased in the patients after surgery, which might be due to the reduced intracranial pressure, improved CSF circulation, and restored myelination.…”

Section: Discussionmentioning

confidence: 83%

Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

Zhao

Li²,

Cao

et al. 2016

Medicine

View full text Add to dashboard Cite

To explore the use of diffusion tensor imaging (DTI) parameters in the quantitative assessment of early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus.Ten patients with communicating hydrocephalus (age: 2–36 months) and 14 age-/gender-matched controls (age: 2–36 months) were enrolled in this study. All patients underwent the ventriculoperitoneal shunt procedure. The imaging data were collected before and 3 months after the operation. Regions of interests (ROIs) included the white matter near the frontal horn of the lateral ventricles (FHLV), the occipital horn of the lateral ventricles (OHLV), occipital subcortical (OS) area, frontal subcortical (FS) area, and thalamus. Fractional anisotropies (FA) and apparent diffusion coefficients (ADC) of the ROIs before and after ventriculoperitoneal shunt were compared between the patients and the controls.Three months after surgery, the patients recovered from the surgery with ameliorated intracranial pressure and slight improvement of clinical intelligence scale and motor scale. Before ventriculoperitoneal shunt, the FA values (except the right FHLV) were significantly decreased and the ADC values were significantly increased in the patients with hydrocephalus, compared with the controls. After the ventriculoperitoneal shunt, the FA values in the FHLV and OHLV of the patients were similar to the controls, but the FA values in other ROIs were still significantly lower than controls. The ADC values in the FS and OS white matter areas of the patients were similar to the controls; however, the ADC values in other ROIs were still significantly higher in patients.The increase of FA and the reduction in ADC in the ROIs preceded the clinical function improvement in patients with high intracranial pressure hydrocephalus and reflected the early changes in brain tissue microstructure, such as the compression of the white matter areas in the ROIs.

show abstract

Section: Discussionmentioning

confidence: 83%

Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

Zhao

Li²,

Cao

et al. 2016

Medicine

View full text Add to dashboard Cite

show abstract

“…43 Cross-sectional studies have shown that DTI parameters can differentiate brain structures with hydrocephalus from normal controls in both human and animal studies. 16,22,27,30,34,38,40–42,44 Initial longitudinal studies have shown that DTI parameters had variable degrees of tendency to return to a normal range after surgery. 2,6,26,36 However, there is also strong evidence from both clinical and experimental studies suggesting that the damage to brain structures suffered before CSF diversion may be irreversible.…”

Section: Introductionmentioning

confidence: 99%

Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes

Mangano

Altaye

McKinstry

et al. 2016

PED

View full text Add to dashboard Cite

OBJECTIVE The purpose of this study was to investigate white matter (WM) structural abnormalities using diffusion tensor imaging (DTI) in children with hydrocephalus before CSF diversionary surgery (including ventriculoperitoneal shunt insertion and endoscopic third ventriculostomy) and during the course of recovery after surgery in association with neuropsychological and behavioral outcome. METHODS This prospective study included 54 pediatric patients with congenital hydrocephalus (21 female, 33 male; age range 0.03–194.5 months) who underwent surgery and 64 normal controls (30 female, 34 male; age range 0.30–197.75 months). DTI and neurodevelopmental outcome data were collected once in the control group and 3 times (preoperatively and at 3 and 12 months postoperatively) in the patients with hydrocephalus. DTI measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values were extracted from the genu of the corpus callosum (gCC) and the posterior limb of internal capsule (PLIC). Group analysis was performed first cross-sectionally to quantify DTI abnormalities at 3 time points by comparing the data obtained in the hydrocephalus group for each of the 3 time points to data obtained in the controls. Longitudinal comparisons were conducted pairwise between different time points in patients whose data were acquired at multiple time points. Neurodevelopmental data were collected and analyzed using the Adaptive Behavior Assessment System, Second Edition, and the Bayley Scales of Infant Development, Third Edition. Correlation analyses were performed between DTI and behavioral measures. RESULTS Significant DTI abnormalities were found in the hydrocephalus patients in both the gCC (lower FA and higher MD, AD, and RD) and the PLIC (higher FA, lower AD and RD) before surgery. The DTI measures in the gCC remained mostly abnormal at 3 and 12 months after surgery. The DTI abnormalities in the PLIC were significant in FA and AD at 3 months after surgery but did not persist when tested at 12 months after surgery. Significant longitudinal DTI changes in the patients with hydrocephalus were found in the gCC when findings at 3 and 12 months after surgery were compared. In the PLIC, trend-level longitudinal changes were observed between preoperative findings and 3-month postoperative findings, as well as between 3- and 12-month postoperative findings. Significant correlation between DTI and developmental outcome was found at all 3 time points. Notably, a significant correlation was found between DTI in the PLIC at 3 months after surgery and developmental outcome at 12 months after surgery. CONCLUSIONS The data showed significant WM abnormality based on DTI in both the gCC and the PLIC in patients with congenital hydrocephalus before surgery, and the abnormalities persisted in both the gCC and the PLIC at 3 months after surgery. The DTI values remained significantly abnormal in the gCC at 12 months after surgery. Longitudinal analysis showed signs of recovery in both WM structures between different time points. Combined with the significant correlation found between DTI and neuropsychological measures, the findings of this study suggest that DTI can serve as a sensitive imaging biomarker for underlying neuroanatomical changes and postsurgical developmental outcome and even as a predictor for future outcomes.

show abstract

“…Thus, it is difficult to determine whether damage occurs prior to or during treatment of hydrocephalus. Diffusion tensor imaging (DTI), a modality of magnetic resonance (MR) imaging, has emerged as a very useful tool in assessing structural changes within the body, especially within the white matter of the brain [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. In this experimental study, we investigated DTI changes in various white matter structures known to be damaged in hydrocephalus to determine whether this modality could identify where and when damage is occurring during infantile hydrocephalus [2,3,[22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging

et al. 2014

View full text Add to dashboard Cite

show abstract

The effects of hydrocephalus on the periventricular white matter in intracerebral hemorrhage: a diffuser tensor imaging study

Cited by 23 publications

References 32 publications

Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes

Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging

Contact Info

Product

Resources

About