The effects of hyperglycaemia on peri-implant tissues after osseointegration

Yamazaki, Seiya; Masaki, Chihiro; Nodai, Tomotaka; Tsuka, Shintaro; Tamura, Akiko; Mukaibo, Taro; Kondo, Yusuke; Ono, Kentaro; Hosokawa, Ryuji

doi:10.1016/j.jpor.2019.07.007

Cited by 17 publications

(16 citation statements)

References 39 publications

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“…In this study, we used an animal model to determine the effect of xerostomia on peri‐implantitis. For the peri‐implantitis model, we used the two‐piece platform switching implant as in a previous study (Yamazaki et al., 2020). This model system mimics the human implant and its surrounding hard and soft tissues, suggesting that the findings of this study could be generalized to clinical results in humans, although improvements of the xerostomia model will be necessary.…”

Section: Discussionmentioning

confidence: 99%

“…19‐006). The primary endpoint was bone resorption around implants, and the sample size was calculated to be approximately eight subjects in each group with a power of 0.80 and α of 0.05 based on data from a similar previous study (Yamazaki et al., 2020) using G*Power 3.1 (Heinrich Heine University of Dusseldorf). All measurements were obtained in a manner blinded to the experimental conditions.…”

Section: Methodsmentioning

confidence: 99%

“…The rat implant model was prepared as previously described (Yamazaki et al., 2020). Briefly, bilateral maxillary first molar extraction was performed, and a 3‐week healing period was provided.…”

Section: Methodsmentioning

confidence: 99%

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Xerostomia aggravates ligation‐induced peri‐implantitis: A preclinical in vivo study

Hori

Kondo

Nodai

et al. 2021

Clinical Oral Implants Res

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Objectives Previous studies have indicated that xerostomia is a critical factor affecting periodontitis; nonetheless, it is controversial whether xerostomia impairs peri‐implant tissue. The objective of this experimental study was to evaluate the effect of xerostomia on the peri‐implant hard and soft tissues in the rat model. Materials and methods Implants were placed in bilateral maxillae of male Wistar rats. The animals underwent submandibular and sublingual gland resection on both sides (DRY group) or sham operation (CTR group). Silk ligatures were placed around one side of abutments, which were randomly selected in each animal. The effects of xerostomia were assessed using micro‐CT, histological analysis, real‐time PCR, and 16S rRNA‐based metagenomic analysis. Results Ligation with silk thread caused bone resorption around implants. Although xerostomia itself did not induce bone resorption, it significantly enhanced silk ligature‐mediated bone resorption around implants. Histological analysis and real‐time PCR indicated that xerostomia induced inflammation and osteoclastogenesis around implants with silk ligatures. Furthermore, it altered the microbiota of the plaque on the silk thread around implants. Conclusion Xerostomia accelerates mucosal inflammation and osteoclastogenesis, which aggravates bone resorption around implants.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Xerostomia aggravates ligation‐induced peri‐implantitis: A preclinical in vivo study

Hori

Kondo

Nodai

et al. 2021

Clinical Oral Implants Res

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“…It is reported that the hyperglycemia impacts the clinical effect of dental implants [5]. Some studies have shown that the early osseointegration around implants would be compromised by T2DM even if glucose is strictly controlled [6]. Thus, it is crucial for clinicians to improve the efficacy of implant treatment in T2DM patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical and radiographic variables related to implants with simultaneous grafts among type 2 diabetic patients treated with different hypoglycemic medications: a retrospective study

et al. 2021

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Background The influence of different hypoglycemic agents on peri-implant variables among type 2 diabetes mellitus patients is still unclear. Therefore, the aim of this study was to assess the radiographic marginal bone loss and clinical parameters around implants in patients using different hypoglycemic agents. Methods In this retrospective cohort study, the dental implant records of type 2 diabetes mellitus patients who met the inclusion criteria were collected. The patients using only single medication as follows: insulin, metformin, or glucagon-like peptide-1 (GLP-1) drugs, were grouped according to their medication. These patients received implant placement with the same initial status, and all the prosthesis restorations were cement-retained ceramic crowns. The peri-implant marginal bone levels were evaluated by periapical radiographs immediately after implant placement and at 1 and 2-year follow-up visits. The baseline characteristics were compared among groups. The peri-implant radiographic marginal bone loss and clinical parameters were preliminarily compared using the Kruskal–Wallis test, and then the covariates were controlled by covariance analysis. Bonferroni post hoc adjustment test was performed for the multiple comparisons. Results After a review of more than 7000 medical records, a total of 150 patients with 308 implants at 1-year follow-up were assessed. The peri-implant marginal bone loss in the GLP-1 drug group was significantly smaller than the insulin group and metformin group (P < 0.01). The radiographic bone loss in the metformin group was higher than the insulin group (P < 0.05). Some of these included patients were lost to follow-up. Only 74 patients with 129 implants completed the 2-year follow-up. The radiographic bone loss in the metformin group was still higher than the insulin group (P < 0.05) and GLP-1 group (P < 0.01). There was no significant difference in the BOP (+) and the mean PD among groups (P > 0.05). Conclusions The radiographic variables were not exactly the same among the patients with different hypoglycemic agents at both the 1 and 2-year follow-ups. After ensuring consistency in baseline characteristics, the positive effect of GLP-1 drugs on peri-implant bone remodeling may be no less than insulin or metformin. More studies are needed to verify the direct effect of these drugs on peri-implant bone. Clinical trial registration number ChiCTR2000034211 (retrospectively registered).

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“…The uncontrolled hyperglycemia would impact the therapeutic effect of dental implants in T2DM 5 . And some studies have shown that early osseointegration around implants is compromised by T2DM even if glucose is strictly controlled 6 . It is crucial for clinicians to promote the e cacy of implant treatment in T2DM patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Radiographic Variables Around Implant With Simultaneous Graft Among Type 2 Diabetic Patients Treated With Different Hypoglycemic Medications: A Retrospective Study.

Shi

Ding

Liu

et al. 2020

Preprint

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Background: The clinical and radiographic variables around dental implants in type 2 diabetes mellitus patients with different hypoglycemic agents still remained unclear.Methods: This retrospective cohort study collected the dental records and digital periapical radiographs of type 2 diabetes mellitus patients and implants. These patients were grouped according to their medication: insulin, metformin, and glucagon-like peptide-1 drugs. The radiographic marginal bone loss around implants and clinical parameters, including peri-implant bleeding on probing and probing depth, were compared among groups using the Kruskal-Wallis test.Results: A total of 150 patients with 308 implants (101 in insulin group, 121 in metformin group and 86 in glucagon-like peptide-1 drugs group) were assessed. The peri-implants marginal bone loss in insulin group (P<0.05) and metformin group (P<0.01) were significantly higher than glucagon-like peptide-1 drug group. The radiographic bone loss in metformin was higher than insulin group (P<0.05). While there was no statistical difference of clinical peri-implant parameters among groups(P>0.05).Conclusions: The radiographic variables were not exactly the same among type 2 diabetes mellitus patients with different hypoglycemic agents. glucagon-like peptide-1 drugs might be more beneficial to bone tissue around implants. More studies are needed to verify the direct effect of these drugs on peri-implant bone.Clinical trial registration number: ChiCTR2000034211 (retrospectively registered)

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The effects of hyperglycaemia on peri-implant tissues after osseointegration

Cited by 17 publications

References 39 publications

Xerostomia aggravates ligation‐induced peri‐implantitis: A preclinical in vivo study

Xerostomia aggravates ligation‐induced peri‐implantitis: A preclinical in vivo study

Clinical and radiographic variables related to implants with simultaneous grafts among type 2 diabetic patients treated with different hypoglycemic medications: a retrospective study

Clinical and Radiographic Variables Around Implant With Simultaneous Graft Among Type 2 Diabetic Patients Treated With Different Hypoglycemic Medications: A Retrospective Study.

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