The Effects of Hyperthermia on the Fetus

Smith, Murray; Edwards, M. J.; Upfold, J. B.

doi:10.1097/00006254-198708000-00013

Cited by 3 publications

(4 citation statements)

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“…Hyperthermia has been implicated as a possible teratogenic factor with the greatest effect on morphogenesis during the early stages of development [5,6]. Date of conception was estimated from the date of birth and the gestational age to determine any seasonal variation associated with the extreme environmental climate in Oman, where the temperature reaches 48°C and the humidity can be 60-80% during the tropical desert summers from April to October.…”

Section: Methodsmentioning

confidence: 99%

Oral clefts in the Sultanate of Oman

Rajab

Thomas

2001

Eur J Plast Surg

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This is a retrospective study of the epidemiology of congenital clefts of the lip and palate in babies of Omani nationals born in the Sultanate of Oman between 1989 and 1995. Babies of non-Omani immigrants were excluded from the study. The data were collected from two sources. The first was the Centralized Plastic Surgery Service of Khoula Hospital at Muscat, the capital city of Oman between 1989 and 1995, which registers all oral cleft cases in the country. These data revealed the overall incidence of oral clefts (OC) to be 1.5 per 1000 live births, with incidences of 0.62 per 1000 for combined lip and palate (CLP) cleft, 0.34 per 1000 for cleft lip (CL), and 0.54 per 1000 for isolated cleft palate (CP). The second data source was national delivery records from maternity sections of all hospitals in the country from 1989 to 1995, which include oral clefts as congenital anomalies identified at birth. These statistics were similar to those from the first source for CL/CLP but underestimated the number of isolated cleft palates (CP). The histories of patients attending the Plastic Surgery Clinic of Khoula Hospital during the last year of the study period could be examined in detail. A study of the 177 OC cases registered in 1995 alone revealed associated congenital anomalies in 38.4%. A higher inbreeding coefficient of 0.0294 was noted among oral cleft cases than in the general population, which was calculated at 0.0198. Familial clefts accounted for 23% of all cases. Greater parental age and birth order were found to be associated with increased risk of oral cleft. High temperatures during the tropical desert summers in Oman (when temperatures reach 48°C) do not seem related to the incidence of oral clefts.

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Section: Methodsmentioning

confidence: 99%

Oral clefts in the Sultanate of Oman

Rajab

Thomas

2001

Eur J Plast Surg

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“… 2 , 3 In this regard, the role of pyrexia in early pregnancy has attracted attention. 4 While the etiological significance of environmental factors remains speculative, there is sufficient evidence to implicate genetic factors. Mutations have been demonstrated in at least eight genes in HD patients, 5 , 6 , 7 which strongly supports a genetic basis for the disease.…”

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confidence: 99%

Clinicopathological features in 102 cases of Hirschsprung disease

Ziad

Katchy

Ramadan

et al. 2006

Annals of Saudi Medicine

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BACKGROUNDHirschsprung disease [HD] is a predominantly childhood disorder of intestinal motility with a multifactorial and polygenic etiology. The objective of this study was to document the clinical and pathological features of HD in Kuwait, which has an estimated consanguinity rate of 54%.METHODSWe analyzed all rectal and colonic biopsies (n=268) for suspected HD identified from the records in the Pathology Department of Al-Sabah Hospital for the period between 1994 and 2004.RESULTSOne hundred and two patients (87 males and 15 females) had histologically confirmed HD. Fifty-eight (57%) were neonates (<1 month of age), while 21% were more than 4 months old. The diagnosis was based on open biopsy in 11 cases and rectal biopsies in 91 cases. Nine patients with open biopsies presented as intestinal obstruction, necrotizing enterocolitis, or perforation. The extent of the disease was unknown in 13 patients. There were 67 males and 3 females with short segment HD. Nine had long segment, two ultra-short segment and eight total colonic aganglionosis (TCA). Five TCA cases involved the small intestine. A skip area was observed in two cases. Six patients had other anomalies. A positive family history for HD was established in three patients. Two of these were male siblings from a consanguineous marriage and had Waardenburg syndrome.CONCLUSIONThis study has highlighted an exceptionally strong male predominance of short segment and a relatively high frequency (5.6%) of small intestinal involvement in HD in Kuwait. These data call for a more detailed epidemiological study with special emphasis on genetics.

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“…Among 8‐year‐old boys and girls in Project Viva, their BRIEF GEC scores were 1.64 points higher if their mothers used acetaminophen ≥10 vs <10 times during pregnancy and were 1.56 points higher if their mothers used any ibuprofen during pregnancy. In the same adjusted models, the estimate for prenatal depression, a known risk factor for behavioural problems, was about 2.2 points and the estimate for smoking during pregnancy was about 1.4 points.…”

Section: Resultsmentioning

confidence: 96%

“…We additionally adjusted infant exposures for gestational age, birthweight for gestational age z‐score, and pregnancy acetaminophen or ibuprofen use. Next, to account for potential confounding by indication, we additionally adjusted for antibiotic use during pregnancy (pregnancy exposure models) and for respiratory tract infections during infancy (infancy exposure models), since infections are a common indication for these medications given their antipyretic properties, and hyperthermia is a fetal neuroteratogen . The number of fever episodes would have been a better potential confounder than antibiotic use, but we did not have this variable available.…”

Section: Methodsmentioning

confidence: 99%

Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid‐childhood executive function and behaviour

Rifas‐Shiman

Cárdenas

Hivert

et al. 2019

Paediatric Perinatal Epid

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Background: Over-the-counter analgesics during pregnancy or infancy may be related to neurobehavioural problems in children, but little is known about effects of different analgesic types, dosage, and timing.Objectives: Examine associations of acetaminophen and ibuprofen use during pregnancy and infancy with executive function and behaviour problems in children. Methods:We included 1225 mother-child pairs from Project Viva, a pre-birth cohort study. We assessed prenatal acetaminophen and ibuprofen use in early and mid-pregnancy and infant use in the first year of life using questionnaires. Parents and classroom teachers assessed child behaviours in mid-childhood (median 8 years), using the Behavior Rating Inventory of Executive Function (BRIEF) and the Strengths and Difficulties Questionnaire (SDQ), with higher scores indicating worse functioning for both. We examined associations of acetaminophen and ibuprofen use during pregnancy and infancy with mid-childhood neurobehavioural outcomes using linear regression models adjusted for potential confounders.Results: During pregnancy, 46.1% of mothers used acetaminophen ≥10 times and 18.4% used any ibuprofen. In the first year, 65.3% and 39.6% of infants received acetaminophen and ibuprofen ≥6 times, respectively. Higher (≥10 vs <10 times) prenatal acetaminophen (β 1.64 points; 95% confidence interval [CI] 0.59, 2.68) and any ibuprofen (β 1.56, 95% CI 0.19, 2.92) were associated with higher parent-rated BRIEF global scores. Patterns of association were linear across categories and were similar for other parent-and teacherrated outcomes. Infancy exposure (≥6 vs <6 times) to acetaminophen (β 1.69, 95% CI 0.51, 2.87) and ibuprofen (β 1.40, 95% CI 0.25, 2.55) were associated with higher parent-rated BRIEF GEC scores but associations with teacher-rated scores were weaker.Conclusions: Prenatal and early-life exposure to acetaminophen and ibuprofen were associated with poorer executive function and behaviour in childhood. These findings highlight the need for further research on the mechanisms through which analgesics may act on fetal and child brain development. K E Y W O R D Sacetaminophen, child behaviour, child executive function, ibuprofen, infancy, pregnancy

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The Effects of Hyperthermia on the Fetus

Cited by 3 publications

References 0 publications

Oral clefts in the Sultanate of Oman

Oral clefts in the Sultanate of Oman

Clinicopathological features in 102 cases of Hirschsprung disease

Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid‐childhood executive function and behaviour

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