The Effects of Hypoxia on Oligodendrocytes in Primary Mouse CNS Cell Cultures

Herschkowitz, N; Reynolds, Richard; Bossi, E

doi:10.1007/978-1-4757-0354-2_30

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1988

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“…It has to be pointed out, how ever, that hypoxia seems to destruct oligodendroglial precursors which could mean a problem for long-term regeneration [37].…”

Section: Myelinationmentioning

confidence: 99%

Brain Development in the Fetus, Neonate and Infant

Herschkowitz

1988

Neonatology

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111

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In structural brain development eight interrelated but distinguishable events can be recognized: (1) neuronal induction, (2) neuroblast proliferation, (3) neuronal migration, (4) neuronal selective aggregation, (5) neuronal differentiation and formation of specific patterns of connection, (6) neuronal death, (7) selective synapse elimination and (8) myelination. The basic mechanisms regulating these developmental events are genetically determined but at any stage of development epigenetic and environmental factors modulate the genetic regulation. This paper reviews representative samples of work in animal experiments and knowledge in human fetal brain development by several authors.

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“…It has to be pointed out, how ever, that hypoxia seems to destruct oligodendroglial precursors which could mean a problem for long-term regeneration [37].…”

Section: Myelinationmentioning

confidence: 99%