The Effects of Loranthus parasiticus on Scopolamine‐Induced Memory Impairment in Mice

Weon, Jin Bae; Lee, Jiwoo; Eom, Min Rye; Jung, Youn Sik; Je, Choong

doi:10.1155/2014/860180

Cited by 9 publications

(9 citation statements)

References 32 publications

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“…In this test for acquisition trial a decrease in EL & increase in TSTQ on 7 th and 14 th days and for probe trial an increase in TSTQ & TSA on 14 th day indicated improvement of spatial learning and memory of rats as compared to disease control and control group. In the study on the effects of Loranthus parasiticus on scopolamine-induced memory impairment in mice almost same outcomes were reported by Weon et al, [39].…”

Section: Discussionsupporting

confidence: 74%

Neuroprotective Effect of Phyllanthus acidus L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

Uddin¹,

Mamun²,

Hossain³

et al. 2016

AAD

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Nature is the best source of complementary and alternative medicine. The plant Phyllanthus acidus (PA) L. has been used traditionally in pain, inflammatory and oxidative stress related disorders. In this consequence, methanolic extract of PA (MEPA) was selected to explore the ability of this plant to enhance cognitive function, brain antioxidant enzymes and anti-acetylcholinesterase activity which can be used for the treatment of oxidative stress related disorders like Alzheimer's disease (AD). The purpose of this study was to investigate the neuroprotective effect of MEPA on learning and memory impairment in scopolamine-induced rats of dementia and oxidative stress. Treatment with MEPA (i.e., 100 and 200 mg/kg b.w.) was investigated in scopolamine-treated Swiss albino male rats for 14 days and its neuroprotective effects were examined using Elevated Plus Maze (EPM) test, Passive Avoidance (PA) test, Novel Object Recognition (NOR) test, Morris Water Maze (MWM) test as well as level of antioxidant enzymes such as catalase (CAT), super oxide dismutase (SOD), glutathione reductase (GSR), glutathione-S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), lipid peroxidation (TBARS) contents and * Corresponding author. Md. S. Uddin et al. 54 acetylcholinesterase (AChE) activity in rat brain tissue homogenates. Administration of MEPA significantly (P < 0.05, P < 0.01; P < 0.01) decreased RTL (retention transfer latency) in rats on 7 th and 14 th day compared to the disease control and control group in the EPM test. In PA test the doses of MEPA suggestively (P < 0.05, P < 0.001; P < 0.05, P < 0.01) increased STL (step-through latency) in rats on 7 th and 14 th day with respect to disease control and control group. For NOR test administration of MEPA considerably (P < 0.01, P < 0.001; P < 0.01) increased the DI (discrimination index) in rats with respect to that of disease control and control group. The doses of MEPA markedly (P < 0.05, P < 0.01; P < 0.01) decreased EL (escape latency) and significantly (P < 0.01, P < 0.001; P < 0.05, P < 0.01) increased TSTQ (time spent in the target quadrant) on successive days as compared to that of disease control and control group in the acquisition trial of MWM test. In case of probe trial of MWM test MEPA administration considerably (P < 0.01; P < 0.05, P < 0.01) increased TSTQ and significantly (P < 0.05, P < 0.01; P < 0.05, P < 0.01) increased TSA (time spent in the annuli) in rats on successive days as compared to that of disease control and control group. MEPA administration significantly (P

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Section: Discussionsupporting

confidence: 74%

Neuroprotective Effect of Phyllanthus acidus L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

Uddin¹,

Mamun²,

Hossain³

et al. 2016

AAD

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“…In PA test an increase in STL on 7 th (after 24 hrs of EL) and 12 th , 13 th , 14 th day (after 24, 48 and 72 hrs of EL) after the acquisition trial indicated improvement of learning and memory of rats as compared to control rats. In the study on Loranthus parasiticus on scopolamine-induced memory impairment in mice by Weon et al, stated increased latency time in this test [54]. MWM test is widely used behavioral tests for studying hippocampus-dependent spatial memory and leaning.…”

Section: Discussionmentioning

confidence: 98%

“…This generated H 2 O 2 is less damaging, although the catalase and gluthatione peroxidase systems can neutralize the H 2 O 2 by converting it to H 2 O and O 2 [57]. CAT is a glycoprotein present in the antioxidant defense system of all cells that protects the cell from oxidative damage done by ROS [54]. It catalyzes the breakdown of H 2 O 2 to H 2 O and O 2 and protects the cell from highly reactive hydroxyl radicals.…”

Section: Discussionmentioning

confidence: 99%

“…Weighed quantity of MEPF was suspended in normal saline (pH 7.4) and administered orally to rats. Based on literature searches the doses of the donepezil hydrochloride and MEPF were selected [31,32]. Standard drug and the suspension of extract were prepared freshly every day and administered before 30 min of the experiment.…”

Section: Administration Of Drugs and Test Compoundsmentioning

confidence: 99%

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Evaluation of Nootropic Activity of Persicaria flaccida on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Implication for the Management of Alzheimer’s Disease

Nasrullah¹,

Hossain²,

Rahman³

et al. 2016

AJPN

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Oxidative stress is the leading cause of neurodegenerative diseases, especially Alzheimer´s disease (AD). The plant Persicaria flaccida (PF) is known in Bengali as red Biskatali belongs to family Polygonaceae. Preliminary studies have shown the antioxidant, anti-inflammatory, analgesic, neuroprotective activities of Biskatali. In this consequence, methanolic extract of PF (MEPF) was selected to explore the ability of this plant to enhance cognitive functions, brain antioxidant enzymes and anti-acetylcholinesterase activity which can be used for the treatment of AD. The objective of this study was to investigate the effects of MEPF on cognitive performance, brain antioxidant enzymes and acetylcholinesterase activity in rats by using behavioral and biochemical study. Treatment with MEPF (i.e., 100 and 200 mg/kg b.w.) was investigated for 14 days in Swiss albino male rats and its effects on different types of memory were examined using Elevated Plus Maze (EPM) test, Passive Avoidance (PA) test, Morris Water Maze (MWM) test as well as level of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GSR), glutathione-S-transferase (GST) and contents of thiobarbituric acid reactive substances (TBARS) in rat brain tissue homogenates. Acetylcholinesterase (AChE) activity was determined by colorimetric method. Administration of highest dose of MEPF significantly (P < 0.05, P < 0.01) decreased retention transfer latency (RTL) of rats on 7 th and 14 th day compared to the control group in EPM test. In PA test highest dose of MEPF meaningfully (P < 0.05, P < 0.01) increased step-through latency (STL) of rats on 7 th , 12 th , 13 th and 14 th day with respect to control group. Both doses of MEPF markedly (P < 0.01, P < 0.001) decreased escape latency (EL), increased time spent in the target quadrant (TSTQ) and time spent in the annuli (TSA) of rats on successive days as compared to that of control group in MWM test. MEPF administration, especially highest dose significantly (P < 0.05, P < 0.01, P < 0.001) increased the level of CAT, SOD, GSR, GST & GSH-Px and considerably (P < 0.01, P < 0.001) decreased TBARS level & AChE activity in the brain tissue homogenates of rats compared to the control group. Behavioral and biochemical studies suggest that MEPF promotes cognitive function by improving different types of memory and reduces oxidative stress by increasing the level of brain antioxidant markers and anti-acetylcholinesterase activity. Therefore, this plant extract can be used for enhancing memory in neurodegenerative disorders like AD.

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“…Weighed quantity of EEPE was suspended in normal saline (pH 7.4) and administered orally to rats at 100 and 200 mg/kg b.w. The duration of the study and doses of donepezil hydrochloride and EEPE were adjusted based on literature searches [39,40] . Every day, standard drug and the suspension of extract were prepared freshly and administered before 30 min of the experiment.…”

Section: Administration Of Drugs and Test Compoundsmentioning

confidence: 99%

Exploring the Effect of Phyllanthus emblica L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer's Disease

et al. 2016

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Neurodegenerative diseases are incurable and debilitating conditions that result in the progressive degeneration of nerve cells, which affect the cognitive activity. Currently, as a result of multiple studies linking Alzheimer's disease (AD) to oxidative damage, the uses of natural antioxidant to prevent, delay, or enhance the pathological changes underlying the progression of AD has received considerable attention. Therefore, this study was aimed at examining the effect of ethanolic extracts of Phyllanthus emblica (EEPE) ripe (EEPEr) and EEPE unripe (EEPEu) fruits on cognitive functions, brain antioxidant enzymes, and acetylcholinesterase (AChE) activity in rat. The effects of EEPEr and EEPEu fruits (i.e., 100 and 200 mg/kg b.w.) were examined in Swiss albino male rats for 12 days and its effect on cognitive functions, brain antioxidant enzymes, and AChE activity determined. Learning and memory enhancing activity of EEPE fruit was examined by using passive avoidance test and rewarded alternation test. Antioxidant potentiality was evaluated by measuring the activity of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase, reduced glutathione (GSH), glutathione-S-transferase, and the contents of thiobarbituric acid reactive substances (TBARS) in entire brain tissue homogenates. AChE activity was determined using colorimetric method. Administration of the highest dose (i.e., 200 mg/kg b.w.) of EEPEr fruit significantly (p < 0.01) and both lowest and highest doses (i.e., 100 and 200 mg/kg b.w.) of EEPEu fruit markedly (p < 0.05, p < 0.001) increased step-through latency in rats on 6th, 11th, and 12th day with respect to the control group. For aforementioned doses, the percentage of memory retention (MR) was considerably (p < 0.05, p < 0.01) increased in rats on 10th, 11th, and 12th days with respect to the control group. The extract, particularly highest dose (i.e., 200 mg/kg b.w.) of EEPEr fruit markedly (p < 0.05) and lowest and highest doses (i.e., 100 and 200 mg/kg b.w.) of EEPEu fruit significantly (p < 0.01) increased the correct responses in rats on 6th, and 12th day related to the control group. In case of this test, the percentage of MR was significantly (p < 0.05, p < 0.01) increased in rats treated with aforementioned doses on 12th day with respect to the control group. The highest dose (i.e., 200 mg/kg b.w.) of EEPEr fruit suggestively (p < 0.05) and both lowest and highest doses (i.e., 100 and 200 mg/kg b.w.) of EEPEu fruit suggestively (p < 0.05, p < 0.01, p < 0.001) increased the levels of SOD, CAT, GSH, GSH-Px and expressively (p < 0.01) decreased the TBARS level compared to the control group. Treatment with the highest dose (i.e., 200 mg/kg b.w.) of EEPEr fruit significantly (p < 0.05) and both lowest and highest doses (i.e., 100 and 200 mg/kg b.w.) of EEPEu fruit markedly (p < 0.01, p < 0.001) decreased the level of AChE activity compared to that of the control group. The present study shows that EEPE fruit possesses an excel...

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The Effects of Loranthus parasiticus on Scopolamine‐Induced Memory Impairment in Mice

Cited by 9 publications

References 32 publications

Neuroprotective Effect of <i>Phyllanthus acidus</i> L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

Neuroprotective Effect of <i>Phyllanthus acidus</i> L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

Evaluation of Nootropic Activity of <i>Persicaria flaccida</i> on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Implication for the Management of Alzheimer’s Disease

Exploring the Effect of <b><i>Phyllanthus emblica</i></b> L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer's Disease

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The Effects of Loranthus parasiticus on Scopolamine‐Induced Memory Impairment in Mice

Cited by 9 publications

References 32 publications

Neuroprotective Effect of &lt;i&gt;Phyllanthus acidus&lt;/i&gt; L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

Neuroprotective Effect of &lt;i&gt;Phyllanthus acidus&lt;/i&gt; L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

Evaluation of Nootropic Activity of &lt;i&gt;Persicaria flaccida&lt;/i&gt; on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Implication for the Management of Alzheimer’s Disease

Exploring the Effect of <b><i>Phyllanthus emblica</i></b> L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer's Disease

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Neuroprotective Effect of <i>Phyllanthus acidus</i> L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

Neuroprotective Effect of <i>Phyllanthus acidus</i> L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

Evaluation of Nootropic Activity of <i>Persicaria flaccida</i> on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Implication for the Management of Alzheimer’s Disease