The Effects of<i>Punica granatum</i>Flower Extract on Skin Injuries Induced by Burn in Rats

Nasiri, Ebrahim; Hosseinimehr, Seyed Jalal; Âkbari, Jafar; Azadbakht, Mohammad; Azizi, Soheil

doi:10.1155/2017/3059745

Cited by 28 publications

(19 citation statements)

References 29 publications

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“…Two papers [ 56 , 57 ] explored the in vivo healing effect of flowers extract. Polyphenols standardization or qualitative characterization were absent; interestingly the latter used a very low dose—0.2% ointment (corresponding to about 2 mg/kg).…”

Section: Resultsmentioning

confidence: 99%

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

et al. 2020

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During the last 30 years, berries have gained great attention as functional food against several risk factors in chronic diseases. The number of related publications on Pubmed rose from 1000 items in 1990 to more than 11,000 in 2019. Despite the fact that a common and clear definition of “berries” is not shared among different scientific areas, the phytochemical pattern of these fruits is mainly characterized by anthocyanins, flavanols, flavonols, and tannins, which showed antioxidant and anti-inflammatory properties in humans. Skin insults, like wounds, UV rays, and excessive inflammatory responses, may lead to chronic dermatological disorders, conditions often characterized by long-term treatments. The application of berries for skin protection is sustained by long traditional use, but many observations still require a clear pharmacological validation. This review summarizes the scientific evidence, published on EMBASE, MEDLINE, and Scholar, to identify extraction methods, way of administration, dose, and mechanism of action of berries for potential dermatological treatments. Promising in vitro and in vivo evidence of Punica granatum L. and Vitis vinifera L. supports wound healing and photoprotection, while Schisandra chinensis (Turcz.) Baill. and Vaccinium spp. showed clear immunomodulatory effects. Oral or topical administrations of these berries justify the evaluation of new translational studies to validate their efficacy in humans.

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Section: Resultsmentioning

confidence: 99%

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

et al. 2020

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“…The decrease in the average size of wounds on day 15 was higher in rats treated with creams containing pomegranate extract than in rats treated with cream containing sulfadiazine. In addition, the wounds completely healed on day 25 in rats treated with creams containing P. granatum flower extract compared with other groups, indicating that pomegranate flower extract promoted wound healing in rats and could be used for managing burn injuries (Nasiri & Hosseinimehr, ).…”

Section: Punica Granatum Lmentioning

confidence: 98%

Natural actives for wound healing: A review

Ataide

Cefali

Croisfelt

et al. 2018

Phytotherapy Research

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Nature has been a source of medicinal treatments for thousands of years, with the use of plants as prototypes for drug development and for the extraction of active compounds. Skin injuries occur regularly in everyday life, and the human skin has the ability to promote repair spontaneously under healthy conditions. However, some intrinsic and external factors may interfere with skins' natural ability, leading to nonhealing lesions and chronic wounds, which directly affect health and quality of life. Thus, attention should be given to this health problem, using an appropriated management when necessary. In this scenario, phytotherapy may be an option for cutaneous wound treatment, although further high-quality studies are needed to firmly establish the clinical efficacy of plants. This article reviews traditionally used natural actives for wound healing, highlighting their characteristics and mode of action.

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“…Anatomical study After 14 days, the sample of the treated rats̓ skin area were collected and fixed in 10% formal saline for (24 -48) h, then dehydrated in a concentration gradient including absolute ethanol, the clearing process was performed by using xylol solution, followed by paraffin wax for infiltrate and embedded process. The paraffin sections cut into 4μmthick section, then stained by Gill haematoxylin and eosin, all slide were photographed and examined with the digital camera that connected to the light microscope (19).…”

Section: Burn Wound Modelmentioning

confidence: 99%

Prangos Platychlaena Boiss Essential Oils: A Novel Study on Its Toxicity, Antibacterial Activity and Chemical Compositions Effect on Burn Rats

Rahman¹

2020

Iraqi J. Agric. Sci.

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The Prangos platychlaena Boiss belonged to the family of Apiaceae is a native medicinal plant of Kurdistan-Iraq. The stem, leaves and flowers of the plant were collected in the mountain of Halgurd of the Kurdistan region of Iraq, and hydrodistilated to obtain the volatile compounds, using both Gas Chromatography ( GC ) and Gas chromatography/ Mass spectroscopy (GC/MS). The results showed that the P. platychlaena Boiss essential oils containing several compounds such as Sylvestrene, α-Pinene oxide, (Z)-Epoxy-ocimene, Borneol, epi-Longipinanol, Germacrene D-4-ol, epi-α-Cadinol, 3-Thujanol acetate and Acorenone with different amount which were not found in any other Prangos species, and all showed antibacterial activity. This experiment was concducted to reveal the toxicity of flowers essentail oils of the P.platychlaena Boiss on skin burns of the rat. The results revealed that the base cream which contains 1% of the essentail oils showd less time in healing wounds in comparing with the other groups. Histological examination of the treated ones showed significantly the formation of new epiderm in those rats which were receiving the base cream containg 1% essentail oils. These finding sugested that the essentail oils of this plant can be used as a surface treatment agent for the human burns.

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The Effects ofPunica granatumFlower Extract on Skin Injuries Induced by Burn in Rats

Cited by 28 publications

References 29 publications

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

Natural actives for wound healing: A review

Prangos Platychlaena Boiss Essential Oils: A Novel Study on Its Toxicity, Antibacterial Activity and Chemical Compositions Effect on Burn Rats

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