The effects of IL-1A and IL-6 genes polymorphisms on gene expressions, hormonal and biochemical parameters in polycystic ovary syndrome

Eser, Betül; Taşkın, Mine İslimye; Hişmioğulları, Adnan Adil; Akşit, Hasan; Bodur, Abdurrahman Said

doi:10.1080/01443615.2016.1256966

Cited by 14 publications

(4 citation statements)

References 23 publications

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“…PCOS is associated with higher serum levels of IL-6 and other inflammatory cytokines [ 2 , 38 ], which could be associated with increased risk of CVD. Metabolic risk in PCOS could be related to IL-6 gene polymorphism [ 39 ] and the metabolic risk may be modified by lifestyle intervention [ 40 ] and metformin treatment [ 41 ]. More studies are needed regarding the long term effect of lifestyle and medical intervention on CVD risk in PCOS.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

Glintborg

Rubin

Nybo

et al. 2018

Cardiovasc Diabetol

152

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BackgroundPolycystic ovary syndrome (PCOS) is associated with obesity and low grade inflammation and the risk for cardiovascular disease (CVD) could be increased in PCOS.MethodsNational register-based study including women with PCOS and no previous diagnosis of CVD, hypertension, or dyslipidemia. PCOS Denmark (N = 18,112) included women with PCOS in the Danish National Patient Register. PCOS Odense University Hospital (OUH, N = 1165) was an embedded cohort including premenopausal women with PCOS and clinical and biochemical examination. Three age-matched controls were included per patient in PCOS Denmark (N = 52,769). The main study outcome was CVD events including hypertension and dyslipidemia defined according to nationwide in- and outpatient hospital contact diagnosis codes and/or inferred from filled medicine prescriptions.ResultsThe age at inclusion was median (quartiles) 29 (23–35) years and follow up was 11.1 (6.9–16.0) years. The Hazard ratio (95% CI) for development of CVD in PCOS Denmark was 1.7 (1.7; 1.8) (P < 0.001) and the total event rate of CVD was 22.6 per 1000 patient years in PCOS Denmark vs. 13.2 per 1000 patient years in controls (P < 0.001). The median age at diagnosis of CVD was 35 (28–42) years in PCOS Denmark vs. 36 (30–43) years in controls (P < 0.001). Obesity, diabetes, and infertility, and previous use of oral contraceptives were associated with increased risk of development of CVD in PCOS Denmark (P < 0.001). Women in PCOS OUH resembled women in PCOS Denmark regarding risk of CVD. Age, BMI, blood pressure, lipid status, and glycemic status predicted development of CVD in PCOS OUH.ConclusionThe event rate of CVD including hypertension and dyslipidemia was higher in PCOS compared to controls. The risk of developing CVD must be considered even in young women with PCOS.Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0680-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

Glintborg

Rubin

Nybo

et al. 2018

Cardiovasc Diabetol

152

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“…The detailed characteristics of the 6 included studies are shown in Table 1 . [ 21 – 26 ] Four studies were performed in Turkey, [ 21 – 23 , 25 ] one in Austria, [ 26 ] and another in India. [ 24 ] The frequencies of each genotype and allele, with their HWE values, are presented in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…[ 24 ] The frequencies of each genotype and allele, with their HWE values, are presented in Table 2 . The analyzed SNP was within the HWE in 3 studies, [ 23 , 25 , 26 ] whereas in the other 3 studies, the polymorphism was not consistent with the HWE. [ 21 , 22 , 24 ] The NOS results indicated that the studies had scores ranging from 6 to 8, with an average of 6.33, which indicated that the methodological quality of the 6 selected studies was generally reliable (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Association between rs1800795 polymorphism in the interleukin-6 gene and the risk of polycystic ovary syndrome

et al. 2018

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Objective:Several published articles have investigated the association between the −174 G/C (rs1800795) polymorphism in the interleukin-6 (IL-6) gene and the risk of polycystic ovary syndrome (PCOS). However, the results were inconsistent. In the present study, a meta-analysis was performed to resolve this inconsistency.Methods:Eligible studies reporting an association between the IL-6 rs1800795 polymorphism and PCOS susceptibility were included from PubMed, Embase, Web of Science, and the Cochrane Library up to December 1, 2017. The odds ratio (OR) with the 95% confidence interval (CI) was used to calculate the strength of the associations. Publication bias detection was conducted using Begg test. We used STATA 11.0 software to perform the statistical analyses.Results:Six articles detailing case-control studies were included, reporting a total of 512 cases and 606 controls. The meta-analysis results indicated that rs1800795 was associated with decreased PCOS susceptibility in the overall population under the allelic model (G vs. C, OR = 0.59, 95% CI: 0.41–0.85, P = .005), the homozygous model (GG vs. CC, OR = 0.45, 95% CI: 0.28–0.73, P = .001), heterozygous model (GG vs. CG, OR = 0.50, 95% CI: 0.26–0.95, P = .036), and the dominant model (GC + CC vs. GG, OR = 0.48, 95% CI: 0.26–0.89, P = .020). However, a threshold P value of .05 was found under the recessive model (CC vs. GG + CG, OR = 0.62, 95% CI: 0.39–1.00).Conclusions:This meta-analysis concluded that IL-6 rs1800795 polymorphism has a decreased association with PCOS risk among all populations studied. The results suggested that the IL-6 rs1800795 polymorphism is a protective factor for PCOS susceptibility. Given the limited ethnic groups and sample size, further studies are required to validate the association.

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“…In reproductive biology, IL-1 is thought to alter ovulation, fertilisation, and implantation due to its inflammatory traits [ 236 ]. According to research, the polymorphism rs1800587 (−889C/T) reduces IL-1 gene transcription through altering IL-1α protein expression in ovarian tissue in Caucasian population [ 85 , 86 ]. Moreover, the first association study of the two IL-1β polymorphism rs 16,944 (−511C/T) and rs 1,143,634 (+ 3953 C/T) and PCOS development was conducted by Kolbus et al in Caucasian population but failed to find a correlation.…”

Section: Il-1mentioning

confidence: 99%

The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis

et al. 2021

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathies affecting the early reproductive age in women, whose pathophysiology perplexes many researchers till today. This syndrome is classically categorized by hyperandrogenism and/or hyperandrogenemia, menstrual and ovulatory dysfunction, bulky multi follicular ovaries on Ultrasonography (USG), and metabolic abnormalities such as hyperinsulinemia, dyslipidemia, obesity. The etiopathogenesis of PCOS is not fully elucidated, but it seems that the hypothalamus-pituitary-ovarian axis, ovarian, and/or adrenal androgen secretion may contribute to developing the syndrome. Infertility and poor reproductive health in women’s lives are highly associated with elevated levels of androgens. Studies with ovarian theca cells taken from PCOS women have demonstrated increased androgen production due to augmented ovarian steroidogenesis attributed to mainly altered expression of critical enzymes (Cytochrome P450 enzymes: CYP17, CYP21, CYP19, CYP11A) in the steroid hormone biosynthesis pathway. Despite the heterogeneity of PCOS, candidate gene studies are the widely used technique to delineate the genetic variants and analyze for the correlation of androgen biosynthesis pathway and those affecting the secretion or action of insulin with PCOS etiology. Linkage and association studies have predicted the relationship between genetic variants and PCOS risk among families or populations. Several genes have been proposed as playing a role in the etiopathogenesis of PCOS, and the presence of mutations and/or polymorphisms has been discovered, which suggests that PCOS has a vital heritable component. The following review summarizes the influence of polymorphisms in crucial genes of the steroidogenesis pathway leading to intraovarian hyperandrogenism which can result in PCOS.

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The effects of IL-1A and IL-6 genes polymorphisms on gene expressions, hormonal and biochemical parameters in polycystic ovary syndrome

Cited by 14 publications

References 23 publications

Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome

Association between rs1800795 polymorphism in the interleukin-6 gene and the risk of polycystic ovary syndrome

The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis

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