The Effects of Iloprost and Vitamin C on Kidney as a Remote Organ After Ischemia/Reperfusion of Lower Extremities

Özcan, Ali; Saçar, Mustafa; Aybek, Hülya; Bir, Ferda; Demi̇r, Süleyman; Önem, Gökhan; Gökşin, İbrahim; Baltalarlı, Ahmet; Çolakoğlu, Nagihan

doi:10.1016/j.jss.2006.04.031

Cited by 39 publications

(36 citation statements)

References 31 publications

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“…The research group investigated the effect of AA on kidney remote organ damage after I/R following abdominal aortic surgery. [7] Their findings imply that AA decreased MDA levels on the kidney after infrarenal I/R in the rat model. According to their results, they demonstrated that AA treatments, before and during the clamping of the abdominal aorta, decreased renal tissue injury from I/R damage.…”

Section: Discussionmentioning

confidence: 94%

“…Malondialdehyde (MDA) is an end product of lipid peroxidation and widely accepted as a marker of ROS-mediated lipid peroxidation in the cell. [7] Cellular defense against free radical injury is provided by enzymatic (catalase, superoxide dismutase, and glutathione peroxidase) and nonenzymatic (alpha tocopherol, ascorbic acid, carotene, urate, etc.) antioxidant systems.…”

Section: Introductionmentioning

confidence: 99%

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The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

Korkmaz

Kolankaya

2009

Renal Failure

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

Korkmaz

Kolankaya

2009

Renal Failure

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“…After the ischemic events taking place in the related tissues, these cases may cause ischemia-reperfusion injuries in the distant organs as well (1)(2)(3). These problems which develop after ischemia-reperfusion may cause high morbidity and mortality after surgical procedures (4).…”

Section: Introductionmentioning

confidence: 99%

“…These problems which develop after ischemia-reperfusion may cause high morbidity and mortality after surgical procedures (4). Organs, in which blood fl ow is high, such as lungs, kidneys, heart and liver, are the most affected distant organs (2).…”

Section: Introductionmentioning

confidence: 99%

Iloprost and vitamin C attenuates acute myocardial injury induced by suprarenal aortic ischemia-reperfusion in rabbits

İriz¹,

İriz²,

Take³

et al. 2015

BLL

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OBJECTIVE: The aim of this study was to evaluate antioxidant and cytoprotective effects of iloprost and Vitamin C in a distant organ after abdominal aorta ischemia-reperfusion injury. MATERIAL AND METHODS: Twenty-eight New Zealand rabbits weighing 2,400-2,800 g were used for this study. The rabbits were divided into four equal groups. These groups are control group, sham group, iloprost group, and iloprost + vitamin C group. Suprarenal aorta was occluded with a vascular clamp. Following 30 minutes of ischemia, the vascular clamp was removed. Rabbits in group 3 received 10 ng/kg/min iloprost and those in group 4 received 10 ng/kg/min iloprost and 10 mg/kg vitamin C. At the end of the reperfusion period, the rabbits were sacrifi ced by a high intraperitoneal dose of xylazine + ketamine injection. Myocardial tissue samples were taken for electron microscopic analysis. We evaluated SOD, MDA and catalase in myocardial tissue samples. RESULTS: Iloprost and iloprost + vitamin C groups signifi cantly reduced the oxidative stress markers in tissue samples (p < 0.05) and signifi cantly decreased the myofi brillar injury and mitochondrial morphology changes in the myocardial tissue as shown with electron microscopy (p < 0.05). Myocardial edema was signifi cantly alleviated by iloprost and iloprost + vitamin C administration (p < 0.05). CONCLUSIONS: This study clearly showed that myocardial injury and edema occurred after ischemia-reperfusion of abdominal aorta and that groups administered with iloprost and iloprost + vitamin C showed an attenuation of ischemia-reperfusion injury in distant organs (Tab. 3, Fig. 4, Ref. 30). Text in PDF www.elis.sk.

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“…Duration of IR in rats exposed to IR was applied as 3 h ischemia and then 1 h of reperfusion as in the study of Ozca et al 34 In groups administered carnitine, dosage of carnitine was 40 mg/kg for low-dose group and 200 mg/kg for high-dose group as in the study of Boonsanit et al 35 Group I (SHAM, n = 8): Laparotomy and infrarenal AA dissection were applied with same surgical duration and stress as in other groups but no occlusion was applied to infrarenal AA. Group II (CC, n = 8): Laparotomy and infrarenal AA dissection were applied but no occlusion was applied to infrarenal AA.…”

Section: Experimental Protocolsmentioning

confidence: 99%

The Role of Carnitine in Preventing Renal Damage Developed as a Result of Infrarenal Aortic Ischemia–Reperfusion

et al. 2011

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Background: This study was designed to use carnitine for preventing deposition of end products of lipid peroxidation in rat models in the prevention of ischemia-reperfusion (IR) damage frequently seen following operations of infrarenal abdominal aorta (AA). Methods: Forty male rats of Sprague-Dawley type were evenly (n = 8) randomized to five groups: sham laparotomy (SHAM), carnitine control (CC), aortic IR (AIR), AIR + low-dose carnitine (AIR+LDC), and AIR + high-dose carnitine (AIR+HDC). Results: Compared to other groups, serum creatinine levels of AIR group were significantly higher. Also tissue malondialdehyde (MDA) levels of AIR group were significantly higher compared to SHAM, CC, and AIR+HDC groups. In histopathological examination, although tubular necrosis atrophy and tubular degeneration observed in AIR group showed regression with low-dose carnitine, tubular necrosis atrophy, tubular degeneration, glomerular damage, and vascular congestion thrombosis decreased with high-dose carnitine. Total score of histological damage was significantly higher in AIR, AIR+LDC, and AIR+HDC groups compared to SHAM and CC groups. Moreover, total score of histological damage was significantly lower in AIR+HDC group than AIR+LDC group. Conclusions: In this study, we showed carnitine can partially prevent renal damage in infrarenal AIR models of rats. This result may open new prospects to us in the prevention of renal IR damage during surgery of aorta.

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The Effects of Iloprost and Vitamin C on Kidney as a Remote Organ After Ischemia/Reperfusion of Lower Extremities

Cited by 39 publications

References 31 publications

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

Iloprost and vitamin C attenuates acute myocardial injury induced by suprarenal aortic ischemia-reperfusion in rabbits

The Role of Carnitine in Preventing Renal Damage Developed as a Result of Infrarenal Aortic Ischemia–Reperfusion

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